Impaired spermatogenesis by testicular sarcoidosis

Takiguchi, Yuichi; Matsuno, Daisuke; Kurosu, Katsushi; Okada, Osamu; Ohta, Sho; Ichikawa, Tomohiko; Kuriyama, Takayuki

doi:10.1111/j.1440-1843.2008.01354.x

Cited by 5 publications

(9 citation statements)

References 10 publications

(15 reference statements)

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“…Treatment was instituted with 60 mg of oral prednisone. Repeat semen analyses showed gradual improvements in sperm count (Takiguchi et al, 2008), similar to the results reported by Svetec et al (1998).…”

Section: Discussionsupporting

confidence: 88%

“…The case of a 23‐year‐old male presenting with ophthalmic sarcoidosis and bilateral uveitis was reported by Takiguchi et al (2008). In this case, the testes were normal in size, but ultrasound identified hypoechoic lesions.…”

Section: Discussionmentioning

confidence: 93%

“…In this case, the testes were normal in size, but ultrasound identified hypoechoic lesions. Although serological investigations for testicular cancer were normal, semen analyses yielded decreased sperm counts and motility (Takiguchi et al, 2008). Treatment was instituted with 60 mg of oral prednisone.…”

Section: Discussionmentioning

confidence: 99%

“…The exact association between infertility and sarcoidosis is unknown (Takiguchi et al, 2008). Given the variable and unpredictable effects of sarcoidosis on the genitourinary tract in general and the testes in particular, affected men should consider semen analysis at the time of diagnosis (Svetec et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis and Treatment of Azoospermia Resulting From Testicular Sarcoidosis

Kovac

Flood

Mullen

et al. 2012

Journal of Andrology

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Genitourinary sarcoidosis is uncommon, with only rare documented cases of testicular involvement reported. We detail the case of a 37-year-old male who initially presented for azoospermia and secondary infertility. A testicular biopsy revealed nonnecrotizing granulomas and a chest x-ray identified perihilar lymphadenopathy and granulomatous lung nodules. A corticosteroid regimen was administered, and routine semen analyses were conducted. Significant improvements were noted after prednisone treatments. A successful in vivo fertilization was obtained. This is the first known case of testicular sarcoidosis diagnosed during investigations into azoospermia and secondary infertility which, after treatment with corticosteroids, resulted in natural fertilization.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and Treatment of Azoospermia Resulting From Testicular Sarcoidosis

Kovac

Flood

Mullen

et al. 2012

Journal of Andrology

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“…Morbidity associated with testicular sarcoidosis includes oligospermia and infertility which are thought to be secondary to the fibrosis and occlusion of the ductus epididymis. 8,28 Treatment with corticosteroids has been shown in some cases to restore spermatogenesis. 28 …”

Section: Discussionmentioning

confidence: 99%

Disseminated Sarcoidosis With Testicular Involvement

Rohani

Rana

Barot

et al. 2014

Clinical Pulmonary Medicine

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Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic lymph nodes. Testicular sarcoidosis is a rare presentation of this disease. We review the case of a patient with stage 2 sarcoidosis with bilateral intrascrotal involvement along with classic pulmonary, lymphoid, and dermatological manifestations. We provide a literature review of testicular sarcoidosis and discuss the diagnostic challenges and the management of intrascrotal mass in setting of disseminated sarcoidosis. (Clin Pulm Med 2014;21:96-100) S arcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the pulmonary system. Although the most common presentation involves granulomatous changes of the lungs and intrathoracic lymph nodes, sarcoidosis can involve almost any organ. Testicular sarcoidosis is a rare manifestation of this disease. CASE REPORTA 46-year-old male from the West Indies with a past medical history significant for Graves disease status-post radioactive ablation and chronic normocytic anemia presented to the emergency room with a chief complaint of testicular discomfort and swelling of 1-year duration. He reported increasing bilateral testicular swelling over the past year and recently had become associated with pain and discomfort. He denied any hematuria, dysuria, urinary discharge, or urinary hesitancy. He reported progressive dyspnea on exertion and a nonproductive cough for the prior 10 months. However, he denied hemoptysis, orthopnea, or paroxysmal nocturnal dyspnea. He noted 30 to 40 pounds of unintentional weight loss over the past year and the presence of nonhealing skin lesions over his right face of >10 months duration. He denied recurrent fevers, chills, or night sweats. His social history was pertinent for heterosexual intercourse with commercial sex workers. He also had a history of inhalational cocaine use 1 year before presentation but denied any tobacco use.At initial presentation, he was afebrile. Heart rate was 115 beats per minute, blood pressure was 124/73 mm Hg, respiratory rate was 16 breaths per minute, and oxygen saturation was 96% on room air.He appeared well-nourished and was not in respiratory distress. Chest auscultation revealed bilateral inspiratory crackles and expiratory wheezes. He was tachycardic with normal heart sounds. Pertinent negative findings included the absence of jugular venous distension, organomegaly, or lower extremity edema. Genitourinary examination revealed bilateral testicular fullness with mild tenderness to palpation. Also noted were multiple, raised, irregular papules on the right side of the face, the largest measuring 1.0 cm by 1.5 cm, and bilateral polygonal scaly plaques over the pretibial areas of the lower extremities that had been present since adolescence (Fig. 1).Laboratory studies revealed normocytic anemia (hemoglobin 11.6 g/dL, MCV 90 fL) with eosinophilia (8.4%) and monocytosis (18.0%). His white blood cell count was within normal range at 4000 cells/mL. His se...

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Current Opinion in Rheumatology

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Impaired spermatogenesis by testicular sarcoidosis

Cited by 5 publications

References 10 publications

Diagnosis and Treatment of Azoospermia Resulting From Testicular Sarcoidosis

Diagnosis and Treatment of Azoospermia Resulting From Testicular Sarcoidosis

Disseminated Sarcoidosis With Testicular Involvement

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