Diagnosis and Treatment of Azoospermia Resulting From Testicular Sarcoidosis

Kovac, Jason R.; Flood, Diane; Mullen, J. Brendan; Fischer, Marc A.

doi:10.2164/jandrol.110.012534

Cited by 12 publications

(11 citation statements)

References 13 publications

(42 reference statements)

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“…duration between ejaculates) as well as pathologies (i.e. diabetes, sarcoidosis (11)), systemic illnesses (i.e. flu) and environmental factors (i.e.…”

Section: Basic Biomarkersmentioning

confidence: 99%

The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility

Kovac

Pastuszak

Lamb

2013

Fertility and Sterility

206

158

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Despite the fact that male factors contribute to approximately 50% of all infertility, the mechanisms underlying their origin are unknown. Currently, clinicians rely primarily on semen analyses to predict male reproductive potential and chart treatment success. Even when invasive procedures are performed, the causes of male infertility frequently remain elusive. Recently, the advent of new technologies has spurred the search for novel male infertility biomarkers, and the detection of genes, proteins or metabolites unique to the infertile male holds much promise. The concept that a cost-effective, non-invasive and accurate set of biomarkers can be identified to diagnose male infertility is tantalizing. This review focuses on the various methodologies employed in the discovery of novel biomarkers along with their findings. Specific attention is paid to recent advances in the fields of genetics, proteomics and metabolomics.

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“…duration between ejaculates) as well as pathologies (i.e. diabetes, sarcoidosis (11)), systemic illnesses (i.e. flu) and environmental factors (i.e.…”

Section: Basic Biomarkersmentioning

confidence: 99%

The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility

Kovac

Pastuszak

Lamb

2013

Fertility and Sterility

206

158

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Section: Discussionmentioning

confidence: 99%

“…In 2012, a novel case report was published by Kovac et al [ 8 ]. This case outlined the first case of sarcoidosis diagnosed upon presentation of infertility secondary to azoospermia [ 8 ]. This patient, similar to the one reported in this paper, fathered two children prior to the infertility [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous Infertility Secondary to Testicular Sarcoidosis: A Case Report

Bathen

Wood

2020

Cureus

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Sarcoidosis is a multisystem disease that can affect any region of the body. Rarely, sarcoid involvement may even involve the male genitourinary tract, including the testicles. Testicular sarcoidosis causes spontaneous and severe effects on male fertility due to obstructive azoospermia. The case presented offers an insight into successful fertility treatment in a patient with obstructive testicular sarcoidosis. The patient and his partner presented to the clinic two years post successful natural conception of their first child with subsequent infertility. Within this period, the male partner was diagnosed with sarcoidosis and was on a treatment plan consisting of methotrexate and glucocorticoids. Complete azoospermia was confirmed via two separate semen analyses six weeks apart. The patient’s testosterone (free and total), thyroid stimulating hormone (TSH), prolactin, follicle stimulating hormone (FSH), and luteinizing hormone (LH) were all within normal limits. With approval of pulmonology, methotrexate was discontinued for three months; however, subsequent semen analysis revealed no improvement. The patient was referred to urology, who confirmed the presence a palpable testicular nodule. Treatment of infertility was eventually achieved via testicular sperm aspiration (TESA) followed by in vitro fertilization (IVF) using intracytoplasmic sperm injection (ICSI). This treatment was successful in achieving one blastocyst and one morula, which were replaced via fresh transfer, resulting in a successful term singleton pregnancy. The possibility of obstructive azoospermia should be considered in males diagnosed with sarcoidosis who are seeking to preserve their reproductive potential.

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“…1,4 Cases of azoospermia due to testicular sarcoidosis have also been reported. 5,6 The most important differential diagnosis for a scrotal mass is testicular malignancy. Both testicular sarcoidosis and testicular malignancy develop in patients of the same age group.…”

Section: Discussionmentioning

confidence: 99%