Impaired serum cholesterol efflux capacity in rheumatoid arthritis and systemic lupus erythematosus

Ronda, Nicoletta; Favari, Elda; Borghi, Maria Orietta; Ingegnoli, Francesca; Gerosa, Maria; Chighizola, Cecilia Beatrice; Zimetti, Francesca; Adorni, Maria Pia; Meroni, Pier Luigi

doi:10.1136/annrheumdis-2012-202914

Cited by 142 publications

(141 citation statements)

References 43 publications

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“…Accordingly, antiatherogenic properties of HDL were reported to be impaired in chronic inflammatory diseases, including RA and systemic lupus erythematosus [7,40,41]. These activities are efficiently carried out by the small, dense HDL3c subfraction which potently promotes cellular cholesterol efflux and protects LDL from oxidative damage [10,30].…”

Section: Discussionmentioning

confidence: 99%

Altered lipidome and antioxidative activity of small, dense HDL in normolipidemic rheumatoid arthritis: Relevance of inflammation

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Altered lipidome and antioxidative activity of small, dense HDL in normolipidemic rheumatoid arthritis: Relevance of inflammation

et al. 2014

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“…In particular, ABCG1-mediated CEC is impaired in RA patients independently of HDL-C levels but inversely correlating with disease activity (Ronda et al 2014). On the one hand, such correlation may reflect the impact of inflammation and autoimmunity on HDL function, but on the other hand, it may indicate the adverse effect of reduced ABCG1-mediated CEC on vessel inflammation and immune reaction promotion.…”

Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 97%

“…Finally, functional impairment of HDL as cholesterol acceptors for cell cholesterol efflux has been reported in RA (Ronda et al 2014;Charles-Schoeman et al 2012), independent of serum HDL-C levels and with a pattern of modifications differing from that found in SLE patients with respect to single cholesterol transporters (Ronda et al 2014). In particular, ABCG1-mediated CEC is impaired in RA patients independently of HDL-C levels but inversely correlating with disease activity (Ronda et al 2014).…”

Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

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Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions

Montecucco

Favari

Norata

et al. 2014

High Density Lipoproteins

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The cholesterol of high-density lipoproteins (HDLs) and its major proteic component, apoA-I, have been widely investigated as potential predictors of acute cardiovascular (CV) events. In particular, HDL cholesterol levels were shown to be inversely and independently associated with the risk of acute CV diseases in different patient populations, including autoimmune and chronic inflammatory disorders. Some relevant and direct anti-inflammatory activities of HDL have been also recently identified targeting both immune and vascular cell subsets. These studies recently highlighted the improvement of HDL function (instead of circulating levels) as a promising treatment strategy to reduce inflammation and associated CV risk in several diseases, such as systemic lupus erythematosus and rheumatoid arthritis. In these diseases, anti-inflammatory treatments targeting HDL function might improve both disease activity and CV risk. In this narrative review, we will focus on the pathophysiological relevance of HDL and apoA-I levels/functions in different acute and chronic inflammatory pathophysiological conditions.

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“…Increased lipid deposition and augmented inflammation in vascular intima have been suggested to underlie accelerated atherosclerosis in ARDs (13). In particular, the association between dyslipidaemia and CV risk in AIRD appears to be more complex compared to the general population (14).…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia in patients with systemic lupus erythematosus: Association with disease activity and B-type natriuretic peptide levels

Yuan

Wang

et al. 2015

Biomedical Reports

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Abstract. The aim of the present study was to evaluate the association between the levels of lipids and B-type natriuretic peptide (BNP) in systemic lupus erythematosus (SLE) patients with heart failure (HF). A total of 46 patients with active SLE and 40 healthy, age-matched control subjects were studied. BNP was measured by an immunofluorescence assay in fresh plasma. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, apolipoprotein (Apo) B, ApoA-I and lipoprotein(a) were assessed. Compared with the control subjects, HDL-C and ApoA-I levels were considerably decreased and TG level increased markedly from SLE patients. The average concentration of HDL-C and ApoA-I in the SLE group with HF was significantly reduced compared to those patients without HF. The results showed that the levels of HDL-C and ApoA-I in SLE patients were negatively correlated with BNP. Disease activity was associated with the TC and TG levels. The present data indicated the presence of a cardiovascular (CV) risk in active SLE with high disease activity, which was demonstrated by the high frequency of dyslipidemia and higher BNP concentrations. Therefore, dyslipoproteinemia may underlie some of the increased risk for CV disease and HF in patients with SLE.

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Impaired serum cholesterol efflux capacity in rheumatoid arthritis and systemic lupus erythematosus

Abstract: CEC is impaired in RA and SLE, with a specific mechanism pattern in each disease not depending on serum HDL levels. These findings provide a new mechanism for the increased atherosclerotic risk in RA and SLE patients.

Cited by 142 publications

References 43 publications

Altered lipidome and antioxidative activity of small, dense HDL in normolipidemic rheumatoid arthritis: Relevance of inflammation

Altered lipidome and antioxidative activity of small, dense HDL in normolipidemic rheumatoid arthritis: Relevance of inflammation

Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions

Dyslipidemia in patients with systemic lupus erythematosus: Association with disease activity and B-type natriuretic peptide levels

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