Dyslipidemia in patients with systemic lupus erythematosus: Association with disease activity and B-type natriuretic peptide levels

Yuan, Jianlin; Li, L I; Wang, Zhaoyan; Song, Weiqing; Zhang, Zongliang

doi:10.3892/br.2015.544

Cited by 23 publications

(20 citation statements)

References 22 publications

(25 reference statements)

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“…Currently, the SLE disease activity index 2000 (SLEDAI-2K) score is widely utilized to assess disease activity in SLE patients (3,4). However, it could be too complex to use in routine clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of the neutrophil‑to‑lymphocyte ratio and hemoglobin insystemic lupus erythematosus

Jiang

Yao

et al. 2018

Exp Ther Med

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The aim of the present study was to evaluate the association of the neutrophil-to-lymphocyte ratio (NLR) and hemoglobin levels with disease activity in patients with systemic lupus erythematosus (SLE) and to explore their clinical significance in predicting SLE. The present study included 212 patients with SLE and 201 healthy controls. All the clinical characteristics were collected from their medical records. The results revealed that the NLR was elevated and the hemoglobin level was markedly decreased in the patients with SLE compared with the healthy controls. NLR was positively correlated with the SLE Disease Activity Index 2000 (SLEDAI-2K), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), whereas it was not correlated with C3 or C4. The hemoglobin level was negatively correlated with SLEDAI-2K, ESR and CRP and positively correlated with C3 and C4. In addition, NLR [EXP(B)=1.986; 95% confidence interval (CI), 1.432-2.753; P=0.001] and hemoglobin [EXP(B)=0.947; 95% CI, 0.929-0.965; P=0.001] were independent predictive factors of SLE. The optimal NLR cut-off value for predicting SLE was 2.075, with 71.14% sensitivity and 69.57% specificity, whereas the optimal hemoglobin cut-off value was 131.5 mg/l, with 75.79% sensitivity and 77.98% specificity. In addition, high NLR together with low hemoglobin levels and high NLR or low hemoglobin levels had increased positive predictive values (86.05 and 66.95, respectively). High NLR with low hemoglobin levels and high NLR or low hemoglobin levels also had higher sensitivity (64.91 and 92.40, respectively) and specificity (64.91 and 18.95, respectively), compared with high NLR alone or low hemoglobin alone. In conclusion, NLR and hemoglobin may reflect SLE disease activity and may be used as markers for predicting the outcome of SLE.

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Section: Introductionmentioning

confidence: 99%

Predictive value of the neutrophil‑to‑lymphocyte ratio and hemoglobin insystemic lupus erythematosus

Jiang

Yao

et al. 2018

Exp Ther Med

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“…This approach reduced the impact of individual differences on the results compared with previous cross-sectional analyses. [ 10 , 18 , 19 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 , 13 , 14 ] Hydroxychloroquine, immunosuppressive drugs like cyclophosphamide, and other medications frequently used in SLE such as ARB/ACEI also influence lipid metabolism. [ 15 – 17 ] Nevertheless, many of the previous studies, which investigated the correlations between lipid profile, atherosclerosis, and SLEDAI [ 7 , 18 , 19 ] ; did not consider the potential effects of medications on the lipid profile. Furthermore, these studies were cross-sectional and based on a western population, which had different prevalence of cardiovascular disease and genetic background from the Asian population.…”

Section: Introductionmentioning

confidence: 99%

Reduction in SLEDAI is associated with improved arterial stiffness in systemic lupus erythematosus

Pang

Ding

et al. 2020

Medicine

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Lipid abnormalities are an important cause of premature atherosclerosis in patients with systemic lupus erythematosus (SLE). This longitudinal study investigates the changes in lipid profile and arterial stiffness with SLE disease activity index (SLEDAI) reduction. Fifty one female SLE patients with baseline SLEDAI ≥ 6 and SLEDAI reduction >3 at 1-year follow-up were included. Neutrophil-to-lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and mean brachial-ankle pulse wave velocity (baPWV) were measured and compared between baseline and 1-year follow-up. Correlations between inflammation biomarkers, SLEDAI, mean baPWV and lipid profile were assessed. We observed significant decreases in ESR, mean baPWV, TG and TC to HDL-C ratio compared with baseline at 1-year follow up, while HDL-C, hsCRP, and NLR were not significantly changed. Significant correlations were found between the reductions in ESR and TG, and SLEDAI and mean baPWV, with adjustment to age, disease duration, blood pressure, and medications (prednisone, immunosuppressants and ARB/ACEI). SLE patients experiencing SLEDAI reductions showed improvements in arterial stiffness. This finding may provide insight into the beneficial effects of reducing SLEDAI on atherosclerosis risk in SLE.

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“…65 As another part of manifestations commonly associated with MetS, SLE patients have an increased frequency of dyslipidemia. 66 Interestingly, dyslipidemia expands the number of autoimmune follicular helper T (Tfh) cells and germinal centers (GC). 67 It is therefore possible that dyslipidemia contributes to the expansion of the number of Tfh cells in SLE patients, a phenotype that correlates with disease activity.…”

Section: Lupus and Sys Temi C Me Tabolis Mmentioning

confidence: 99%

Metabolic determinants of lupus pathogenesis

Teng

Brown

Choi

et al. 2020

Immunological Reviews

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The metabolism of healthy murine and more recently human immune cells has been investigated with an increasing amount of details. These studies have revealed the challenges presented by immune cells to respond rapidly to a wide variety of triggers by adjusting the amount, type, and utilization of the nutrients they import. A concept has emerged that cellular metabolic programs regulate the size of the immune response and the plasticity of its effector functions. This has generated a lot of enthusiasm with the prediction that cellular metabolism could be manipulated to either enhance or limit an immune response. In support of this hypothesis, studies in animal models as well as human subjects have shown that the dysregulation of the immune system in autoimmune diseases is associated with a skewing of the immunometabolic programs. These studies have been mostly conducted on autoimmune CD4 + T cells, with the metabolism of other immune cells in autoimmune settings still being understudied. Here we discuss systemic metabolism as well as cellular immunometabolism as novel tools to decipher fundamental mechanisms of autoimmunity. We review the contribution of each major metabolic pathway to autoimmune diseases, with a focus on systemic lupus erythematosus (SLE), with the relevant translational opportunities, existing or predicted from results obtained with healthy immune cells. Finally, we review how targeting metabolic programs may present novel therapeutic venues. K E Y W O R D Sglucose, glutamine, lupus, metabolic inhibitors, metabolism

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Dyslipidemia in patients with systemic lupus erythematosus: Association with disease activity and B-type natriuretic peptide levels

Cited by 23 publications

References 22 publications

Predictive value of the neutrophil‑to‑lymphocyte ratio and hemoglobin insystemic lupus erythematosus

Predictive value of the neutrophil‑to‑lymphocyte ratio and hemoglobin insystemic lupus erythematosus

Reduction in SLEDAI is associated with improved arterial stiffness in systemic lupus erythematosus

Metabolic determinants of lupus pathogenesis

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