Impaired response inhibition function in abstinent heroin dependents: An fMRI study

Fu, Liping; Bi, Guo‐Hua; Zou, Zhitong; Wang, Yan; Ye, En-mao; Ma, Lin; Ming-Fan,; Zheng, Yang

doi:10.1016/j.neulet.2008.04.033

Cited by 209 publications

(133 citation statements)

References 27 publications

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“…Abstaining individuals with opiate dependence were found to have slower go reaction times and less brain activation than controls during task performance in the key regions implicated in inhibitory control, such as the bilateral ACC, medial PFC, bilateral IFG, left MFG, left insula and right SPL. 93 Hypoactivation in individuals with opiate dependence was also extended to regions outside the inhibitory control network into the left uncus, left PHG, right precuneus and right MTG. However, go and nogo stimuli in this study were presented in blocks, such that inhibitory requirements were very low.…”

Section: Inhibitory Control In Individuals With Opiate Dependencementioning

confidence: 99%

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Luijten

Machielsen

Veltman

et al. 2014

J Psychiatry Neurosci

316

300

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Section: Inhibitory Control In Individuals With Opiate Dependencementioning

confidence: 99%

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Luijten

Machielsen

Veltman

et al. 2014

J Psychiatry Neurosci

316

300

View full text Add to dashboard Cite

“…This finding contradicts to the findings ofWang et al 2010 who reported significant functional connectivity between ventral aspects of anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC)/ medial PFC. Finally, Yuan et al (2010) reported that a distributed brain network that is involved in drug addiction and consists of ACC, amygdala, OFC, DLPFC, NAc, MPFC and insula according to the existing literature (Wilson et al, 2004;Lee et al, 2005;Fu et al, 2008;Yuan et al, 2009). Another study (Yuan et al, 2010b) of the same research group revealed a reduced rsFC between the right DLPFC and the left inferior parietal lobe (IPL).…”

Section: Resting-state Functional Connectivity Alterations In Heroin mentioning

confidence: 99%

Resting-state Abnormalities in Heroin-dependent Individuals

Pandria

Kovatsi

Vivas³

et al. 2018

Neuroscience

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractDrug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific regions in the prefrontal, parietal, occipital, and temporal lobes, as well as, some subcortical regions.The brain regions involvedare linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control andseem to form circuitsthat interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively reviewand discuss all the existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapya multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games Keywords:Heroin addiction, resting-state, functional and structural connectivity, small-world properties, behavioral traits of heroin-dependent individuals. Radial Diffusivity (RD) 5 Drug addiction or substance dependence (Koob and Le Moal, 2005)is defined as a multifaceted neuropsychiatric disorder resulting from complex interactions between neurobiological, environmental, genetic and pharmacological variables (Sutherland et al., 2012).It affects both cognitive as well as emotional processes . Furthermore, the compulsive seeking and taking of the drug despite the negative consequences, (including downward social mobility (Denier et al., 2013b)), constitutes its behavioral phenotype (Volkow ...

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“…Instead, selfcontrol and reward are likely inter-related modules that, when broken down, facilitate the transition from initial drug use to dependence. 23,41 "Loss of control" can be further categorized into subcomponents based on the environmental trigger, such as stress, emotion, incentive salience, pain, and/or decisionmaking. 1 Support for the loss of control that takes place during drug craving comes in part from cue-elicited work using a 2×2 factorial design to explore neural correlates to drug and neutral stimuli in addition to using both substance abusers and controls.…”

Section: Sofis Et Almentioning

confidence: 99%

Competing neurobehavioral decision systems and the neuroeconomics of craving in opioid addiction

Sofis¹,

Jarmolowicz

Martin³

2014

NAN

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Abstract:Craving is typically thought of as a classically conditioned response characterized by an elevated mesolimbic dopamine response to drug-related stimuli. Although this definition has spurred considerable research, the clinical impact of the research conducted has been less robust. The current review takes a more contemporary approach by conceptualizing craving as the breakdown of executive function and relative strengthening of the limbic system, occurring in the presence of conditioned cues, leading to a maladaptive craving response (ie, an increased likelihood of drug consumption). Working from this framework, the present review focuses on four issues in drug craving research: pivotal findings and limitations of cue-reactivity and neurocognitive tasks; two main processes of craving that include self-control and reward-based explanations; integration of neuroeconomic approaches to craving; and the theoretical implications and future directions of drug craving research.

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Impaired response inhibition function in abstinent heroin dependents: An fMRI study

Cited by 209 publications

References 27 publications

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Resting-state Abnormalities in Heroin-dependent Individuals

Competing neurobehavioral decision systems and the neuroeconomics of craving in opioid addiction

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