Impaired Pain Modulation in Fibromyalgia Patients in Response to Social Distress Manipulation

Canaipa, Rita; Castro-Caldas, Alexandre; Moreira, João Manuel; Pimentel-Santos, Fernando; Branco, Jaime; Treister, Roi

doi:10.1097/ajp.0000000000000447

Cited by 5 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is commonly accepted that negative emotional situations, e.g., social exclusion and pessimism, are associated with increased pain, while positive emotions are associated with decreased pain perception ( Hanssen et al, 2013 ). In our study, social exclusion decreased pain perception in PDM females, which was consistent with findings in fibromyalgia patients ( Canaipa et al, 2017 ). Social pain and physical pain have similar psychological and neurological processing ( Eisenberger, 2012 ).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model

Chen

et al. 2021

Front. Syst. Neurosci.

View full text Add to dashboard Cite

The anterior cingulate cortex (ACC) and hippocampus (HIPP) are two key brain regions associated with pain and pain-related affective processing. However, whether and how pelvic pain alters the neural activity and connectivity of the ACC and HIPP under baseline and during social pain, and the underlying cellular and molecular mechanisms, remain unclear. Using functional magnetic resonance imaging (fMRI) combined with electrophysiology and biochemistry, we show that pelvic pain, particularly, primary dysmenorrhea (PDM), causes an increase in the functional connectivity between ACC and HIPP in resting-state fMRI, and a smaller reduction in connectivity during social exclusion in PDM females with periovulatory phase. Similarly, model rats demonstrate significantly increased ACC-HIPP synchronization in the gamma band, associating with reduced modulation by ACC-theta on HIPP-gamma and increased levels of receptor proteins and excitation. This study brings together human fMRI and animal research and enables improved therapeutic strategies for ameliorating pain and pain-related affective processing.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Social pain and physical pain have similar psychological and neurological processing ( Eisenberger, 2012 ). The experience of long-term physical pain may lead to social-pain numbing ( DeWall and Baumeister, 2006 ; Canaipa et al, 2016 , 2017 ). Thus, social exclusion (social pain) has less influence on PDM females.…”

Section: Discussionmentioning

confidence: 99%

Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model

Chen

et al. 2021

Front. Syst. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The current study shows that, in contrast to HC, socially excluded individuals with DM demonstrate an increase in both pain threshold and tolerance to pain in response to cold stimulation. However, similar to fibro-myalgia patients, 16 having experienced social inclusion, DM sufferers demonstrate decreased pain threshold and tolerance. These results suggest that the modifying effect of social experience on the pain process differs in DM compared to HC participants, which unambiguously supports our hypothesis that an individual’s prior pain experience differentially modulates the effects of social pain on the sensitivity to and tolerance of physical pain.…”

Section: Discussionmentioning

confidence: 90%

“…The time when participants withdrew their hand from the water indicated their cold pain tolerance, measured in seconds. 16 The experimenter ended the assessment when the participant took her hand out of the water or after three minutes had elapsed. 28 …”

Section: Methodsmentioning

confidence: 99%

“… 14 In fact, they are playing with a preprogrammed computer that enrolls the participant into one of two conditions: a condition in which the participant is socially included (inclusion condition) and one in which he or she is excluded from the game (exclusion condition). 15 , 16 There is growing recognition that social and physical pain share many of the same neural and psychological mechanisms. 15 Emerging evidence shows that social pain relies on some of the same neural regions that process physical pain, highlighting a possible network overlap of physical and social pain, 11 resulting in heightened perception of social exclusion due to physical injury; conversely, perception of social exclusion can trigger feelings of physical pain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Disrupted physical pain sensation by social exclusion in women with dysmenorrhea

Yu¹,

Guan²,

Fu³

et al. 2018

JPR

View full text Add to dashboard Cite

PurposeDysmenorrhea (DM), which involves both acute and chronic pain, is associated with abnormalities in pain modulation. Previous studies have shown that social pain relies on some of the same neural regions that process physical pain, highlighting a possible physical–social pain overlap. However, evidence suggesting that social pain modulates the sensitivity to physical pain remains controversial. The present study aimed to assess the effects of social pain manipulation on sensitivity to physical pain in DM sufferers and healthy female controls (HC).Materials and methodsFifty-nine otherwise healthy patients with DM and 55 HC matched for age, education, calendar age, and gynecological age were randomly assigned to inclusion or exclusion conditions of Cyberball, a virtual ball tossing game used to induce social pain (social exclusion). Pain threshold and pain tolerance in response to nociceptive pressure and cold stimuli were assessed before and after the study condition.ResultsIn response to cold stimulation, pain threshold and tolerance significantly reduced in DM compared to HC participants in the inclusion condition, indicating increased pain sensitivity in DM group. However, exclusion increased the pain threshold and tolerance compared to inclusion in DM but decreased pain threshold and tolerance in HC. Neither inclusion nor exclusion altered pressure pain sensitivity in DM, but, after social exclusion, DM participants were more fearful of being evaluated unfavorably. No significant differences were observed in self-esteem scores between DM and HC after both inclusion and exclusion.ConclusionWe observed altered pain sensation in DM participants in response to social pain manipulation, suggesting that DM not only impacts menstruation but also modulates the perception of pain more generally, especially its affective processes. The present study suggests that the effect of social pain on pain sensation and certain psychometric properties depends on previous pain experience, implicating a reciprocal influence of social and physical pain processes.

show abstract

Acute Ostracism-Related Pain Sensitization in the Context of Accumulated Lifetime Experiences of Ostracism

Nanavaty

Walsh

Boring

et al. 2023

The Journal of Pain

View full text Add to dashboard Cite

Impaired Pain Modulation in Fibromyalgia Patients in Response to Social Distress Manipulation

Cited by 5 publications

References 39 publications

Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model

Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model

Disrupted physical pain sensation by social exclusion in women with dysmenorrhea

Acute Ostracism-Related Pain Sensitization in the Context of Accumulated Lifetime Experiences of Ostracism

Contact Info

Product

Resources

About