Impaired lymphocyte reactivity against tumour cells in patients with Crohn's disease

Maclaurin, B. P.; Cooke, W. T.; Ling, N. R.

doi:10.1136/gut.13.8.614

Cited by 12 publications

(2 citation statements)

References 20 publications

(21 reference statements)

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“…Some immunologic changes in Crohn's disease are believed to create a predisposition for lymphoma development. Maclaurin et al determined that lymphocyte reactivity against tumor cells was disrupted in patients with Crohn's disease [ 2 ]. Moreover, diseases associated with chronic inflammation, such as Hashimoto's thyroiditis, myoepithelial sialoadenitis, Helicobacter -related gastritis, rheumatoid arthritis, and Sjögren's syndrome, generate a predisposition for lymphoma development, as well [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

A Burkitt's Lymphoma Case Mimicking Crohn's Disease: A Case Report

Erkan

Çoban

Çalışkan

et al. 2011

Case Reports in Medicine

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Lymphomas are solid tumors that arise from lymphoid tissue and present themselves as Hodgkin's or non-Hodgkin's lymphoma. Particularly gastrointestinal lymphomas can be clinically confused with other gastrointestinal tumors as well as with diffuse and inflammatory bowel disease. Early diagnosis and treatment bear vital importance in the management of lymphomas due to their high proliferation rates. In this report, we are presenting a case which initially displayed clinical and radiological signs of Crohn's disease, but was eventually diagnosed as Burkitt's lymphoma by laparotomy, and also we aim to underscore the importance of differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

A Burkitt's Lymphoma Case Mimicking Crohn's Disease: A Case Report

Erkan

Çoban

Çalışkan

et al. 2011

Case Reports in Medicine

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“…An intermittently circulating lymphocytotoxic autoantibody might also explain the tendency to hyposplenism and splenic atrophy in coeliacs in later life (Marsh and Stewart, 1970;Bullen and Losowsky, 1978). Splenic atrophy is in turn related to impaired function of lymphocyte subpopu-lations in coeliac disease (Bullen and Losowsky, 1978;Maclaurin, Cooke and Ling, 1971). The frequent finding of splenic atrophy is also compatible with the view that coeliac disease is caused by a chronic graft versus host reaction as postulated by Neild (1981) and might therefore be related to the reported increased incidence of malignant lymphomas and other tumours (Gough, Read and Nash, 1962;Harris et al, 1967;Asquith and Haeney, 1979).…”

Section: The Histocompatibility Antigensmentioning

confidence: 99%

Present trends in coeliac disease

Shiner¹

1984

Postgraduate Medical Journal

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Occurrence of cancer in immune deficiencies

Penn¹

1974

Cancer

105

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The immune system plays an important role in the host's defenses against cancer. Immunodeficiency states are associated with an increased incidence of neoplasia. In primary immunodeficiency states, the frequency of malignancy is roughly 10,000 times that in the general age‐matched population. Immunosuppressed organ homograft recipients have a 5–6% risk of the development of de novo cancers. In addition, malignant cells may be inadvertently transplanted from donors with cancer and may grow in the transplanted organ, invade surrounding structures, and produce widespread metastases. Cancers may also develop in nontransplant patients treated with immunosuppressive therapy. There is also much circumstantial evidence suggesting that cancer chemotherapy, while allowing control of one cancer, may permit or induce the growth of a second neoplasm. These findings have important implications for the management of patients with malignancies, as other forms of cancer treatment such as radical surgical procedures and radiotherapy may also impair the host's resistance to cancer. It therefore behooves us to reappraise our methods of cancer therapy and examine their effects upon the host's resistance to his neoplasm.

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Impaired lymphocyte reactivity against tumour cells in patients with Crohn's disease

Cited by 12 publications

References 20 publications

A Burkitt's Lymphoma Case Mimicking Crohn's Disease: A Case Report

A Burkitt's Lymphoma Case Mimicking Crohn's Disease: A Case Report

Present trends in coeliac disease

Occurrence of cancer in immune deficiencies

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