Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease

Maclaurin, B. P.; Cooke, W. T.; Ling, N. R.

doi:10.1136/gut.12.10.794

Cited by 29 publications

(10 citation statements)

References 13 publications

(14 reference statements)

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“…Our findings would support this hypothesis and suggest that the majority of lymphocytes attracted to the gut are T cells. The lymphoreticular dysfunction (McCarthy et al, 1966), impaired blast transformation produced by non-specific mitogens (Blecher et al, 1969;Asquith, 1974), reduced cytotoxic capacity of lymphocytes against tumour cells in vitro (McClaurin et al, 1971), and the increased incidence of gut lymphomas found in coeliac disease (Austad et al, 1967;Harris et al, 1967) are considered to be evidence of cell mediated immunodysfunction in this condition. The depletion of T cells, which are of prime importance in cell mediated reactions, could therefore have some bearing on these deficiencies and it might be that the return to normal numbers of T cells after a gluten free diet is the reason for the reduced incidence ofgut neoplasms in treated coeliacs compared with untreated patients (Harris et al, 1967;Holmes et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

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T cell depletion in untreated adult coeliac disease.

O’Donoghue¹,

Lancaster-Smith²,

Laviniere³

et al. 1976

Gut

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Section: Discussionmentioning

confidence: 99%

“…In addition, impaired function of circulating lymphocytes, probably T cells, occurs in this disorder (Blecher et al, 1969;McClaurin et al, 1971). The numbers of circulating T lymphocytes in coeliac disease might have an important bearing upon these phenomena.…”

mentioning

confidence: 99%

T cell depletion in untreated adult coeliac disease.

O’Donoghue¹,

Lancaster-Smith²,

Laviniere³

et al. 1976

Gut

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“…In vivo skin tests of cellmediated immunity (CMI) have not been reported (except to gluten) but several groups (Winter et al, 1967;Blecher et at., 1969;Housley et al, 1969;Ansaldi et al, 1970;Popovic et al, 1970;Maclaurin et at., 1971;Morganroth et at., 1972), have studied lymphocyte transformation in response to PHA which Received for publication 29 June 1976 is the usual in vitro test of CMI. It can be seen (Table 1) that the results are inconclusive.…”

mentioning

confidence: 99%

Depressed cell-mediated immunity in coeliac disease.

Scott¹,

Losowsky²

1976

Gut

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SUMMARY Fourteen coeliac patients on a gluten free diet (GFD) and 10 on a normal diet were studied by lymphocyte transformation in response to PHA to assess the integrity of cell-mediated immunity (CMI). Transformation was depressed in the majority taking a normal diet, with improvement after a GFD. In some patients the depression may have been due to a serum factor, as transformation was more nearly normal when the lymphocytes were cultured in pooled AB serum than in their own serum. There was no correlation between transformation and nutritional deficiencies. Mantoux tests were performed in some of these and other coeliac patients and there was a very significant reduction in the incidence ofpositive tests compared with controls. These findings provide evidence of depressed CMI in coeliac patients taking a normal diet with improvement on a GFD and may be of relevance to the high risk of malignancy in coeliac disease, further strengthening the case for a strict GFD.

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“…A full description of the methods used has been given in an earlier paper (Maclaurin, Cooke, and Ling, 1971). …”

Section: Methodsmentioning

confidence: 99%

“…5 and compared with the mean responses of 11 normal subjects (quoted by Maclaurin et al, 1971). It will be noted that in two patients cytotoxicity was virtually absent and in a third it was markedly diminished and below the range for the normal subjects studied.…”

Section: Cytotoxicitymentioning

confidence: 99%