Impaired long contact white matter fibers integrity is related to depression in Parkinson's disease

Wu, Jinjin; Zhang, Yang; Wu, Wenbo; Hu, Gang; Xu, Yun

doi:10.1111/cns.12778

Cited by 39 publications

(40 citation statements)

References 37 publications

(91 reference statements)

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“…In addition to reduced FA in the genu and body of corpus callosum, left cingulum, and bilateral anterior and left superior corona radiata seen in PD subjects with apathy . Studies investigating depression in PD noted a reduction of FA in WM tracts of left anterior thalamic radiation, uncinate, and left anterior corona radiata, among others …”

Section: Discussionmentioning

confidence: 92%

“…14 Studies investigating depression in PD noted a reduction of FA in WM tracts of left anterior thalamic radiation, uncinate, and left anterior corona radiata, among others. 38 The differentiation of clinical symptoms was also observed in a study using PLS in order to relate brain atrophy with a range of clinical measures. 39 Interestingly, they found three distinct patterns of clinical presentations of PD, each related to a distinct atrophy pattern of gray matter.…”

Section: Discussionmentioning

confidence: 99%

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White matter myelin profiles linked to clinical subtypes of Parkinson's disease

Baumeister

Kim

Zhu

et al. 2018

Magnetic Resonance Imaging

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Background White matter (WM) microstructural integrity is important for effective brain functioning and alterations have been shown in many neurodegenerative diseases. Purpose To investigate WM myelin profiles and their relation to clinical features of Parkinson's disease (PD). Study Type Retrospective cross‐sectional. Population In all, 29 PD subjects and 15 healthy controls. Field Strength/Sequence Multiecho GRASE with 10 msec echo spacing and echo planar imaging (EPI) diffusion‐weighted (b‐value = 700 with 32 gradient directions) on a 3T scanner. Assessment Myelin water fraction (MWF) and fractional anisotropy (FA) across 20 WM regions of interest (ROIs) were compared between groups. Partial least squares (PLS) was used to associate MWF and FA with clinical and behavioral measures. Statistical Tests Group comparisons were done using two‐sample t‐tests. PLS was assessed with permutation tests. Bootstrapping was used to investigate the robustness of imaging features. Results No group differences in myelin content could be detected with univariate tests. A three‐component PLS model linked MWF profiles to clinical phenotypes but no FA profiles. The three components appeared to follow along broad motor/nonmotor subtypes of “akinetic‐rigid,” “tremor‐predominant,” and “depression/apathy” subtypes, respectively. The first component showed associations between overall motor scores (r = –0.43, P = 0.0196) and cognitive performance (r = 0.44, P = 0.0171) with interhemispheric and long‐range association fibers. A second component linked overall motor scores (r = –0.58, P = 0.0009) and tremor scores (r = –0.48, P = 0.0091) to predominantly projection fibers. The last component related depression (r = –0.60, P = 0.0006) and apathy scores (r = –0.66, P = 0.0001 and r = –49, P = 0.0072) to a mixture of association and projection fibers. Data Conclusion MWF was robustly linked to distinct clinical subtypes of PD and may serve as an additional tool to characterize the disease. Level of Evidence: 4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:164–174.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

White matter myelin profiles linked to clinical subtypes of Parkinson's disease

Baumeister

Kim

Zhu

et al. 2018

Magnetic Resonance Imaging

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“…Parkinson's disease (PD) is a progressive degenerative CNS disorder that affects the motor system. It is characterized by a profound degeneration of dopaminergic neurons in the brain, accompanied by chronic neuroinflammation, mitochondrial dysfunction, and widespread accumulation of α‐synuclein‐rich protein in Lewy's bodies . It has been proved that the α‐synuclein is a potent stimulator of inflammasome.…”

Section: Inflammasome Activation In Microglia/macrophage Is the Resulmentioning

confidence: 99%

“…It is characterized by a profound degeneration of dopaminergic neurons in the brain, accompanied by chronic neuroinflammation, mitochondrial dysfunction, and widespread accumulation of α-synuclein-rich protein in Lewy's bodies. [43][44][45] It has been proved that the α-synuclein is a potent stimulator of inflammasome. Fibrillar α-synuclein in microglia leads to impairment of mitochondrial endocytosis and lysosomal dysfunction, which cause ROS dysregulation and activate inflammasome.…”

Section: Inflammasome Activation In Parkinson's Diseasementioning

confidence: 99%

Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease

Lin

Zhang

et al. 2019

CNS Neurosci Ther

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Aging and aging‐related CNS diseases are associated with inflammatory status. As an efficient amplifier of immune responses, inflammasome is activated and played detrimental role in aging and aging‐related CNS diseases. Macrophage and microglia display robust inflammasome activation in infectious and sterile inflammation. This review discussed the impact of inflammasome activation in microglia/macrophage on senescence “inflammaging” and aging‐related CNS diseases. The preventive or therapeutic effects of targeting inflammasome on retarding aging process or tackling aging‐related diseases are also discussed.

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“…However, selective abnormalities in dopamine and other neurotransmitters in the limbic system were observed in PD patients with depression relative to PD patients without depression (12). Abnormalities in functional connectivity in the prefronto-limbic system (13) and structures in the prefrontal lobe, limbic system, and temporal lobe (14) were reported to be associated with depression in PD patients. Therefore, detecting the brain structural alterations in PD patients with depression may find markers for early diagnosis of PD.…”

Section: Introductionmentioning

confidence: 99%

Changed Resting-State Brain Signal in Parkinson's Patients With Mild Depression

et al. 2020

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Background: Depression is reported to occur 5-10 years early than the onset of motor symptoms in Parkinson (PD) patients. However, markers for early diagnosis of PD in individuals with sub-clinical depression still remain to be identified.Purpose: This study utilized Regional Homogeneity (ReHo) to investigate the alterations in resting state brain activities in Parkinson (PD) patients with different degrees of depression.Methods: Twenty non-depressed PD patients, twenty mild to moderately depressed PD patients, and thirteen severely depressed PD patients were recruited. Hamilton Depression Scale (HDS) and the Beck Depression Inventory (BDI) were assessed depression. Resting-state functional magnetic resonance imaging (rs-MRI) was analyzed with ReHo.Results: PD patients with mild to moderate depression had decreased ReHo in the left dorsal anterior cingulate cortex when compared with PD patients without depression. PD patients with severe depression exhibited increased ReHo in the left inferior prefrontal gyrus and right orbitofrontal area when compared with PD patients with mild to moderate depression. ReHo values in the bilateral supplementary motor area (SMA) in PD patients with severe depression was also increased when compared with PD patients without depression. Conclusions:This study suggests that rs-MRI with ReHo analysis can detect early changes in brain function that associate with depression in PD patients, which could be biomarkers for early diagnosis and treatment of PD related depression.

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Impaired long contact white matter fibers integrity is related to depression in Parkinson's disease

Abstract: This study suggested depression in PD was related to impaired white matter integrity especially the long contact fibers in the left hemisphere. These findings may be helpful for further understanding the potential mechanisms underlying depression in PD.

Cited by 39 publications

References 37 publications

White matter myelin profiles linked to clinical subtypes of Parkinson's disease

White matter myelin profiles linked to clinical subtypes of Parkinson's disease

Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease

Changed Resting-State Brain Signal in Parkinson's Patients With Mild Depression

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