Impaired glucose tolerance is a risk factor for stroke in a Japanese sample—the Funagata study

Statins Cardiovascular Benefits Outweigh their Diabetogenicity: A Direct Comparison between Number Needed to Treat and Number Needed to Harm

“…A glycemic disorder begins long before DM diagnosis [46], and type 2 DM requires a long latency period until cardiovascular events become manifest. In fact, major cardiovascular event rates cumulatively increased in proportion to the length of observation period [47,48]. On the other hand, the mean or median observation period of the studies in the present study is only between 1.9 and 6.1 years, suggesting that a firm conclusion concerning the statins' risk-benefit balance awaits further investigation.…”

Epidemiological Evidence of Type 2 Diabetes Mellitus, Metabolic Syndrome, and Cardiovascular Disease in Japan

“…The Funagata study also extended the follow-up period and found that type 2 DM was a risk factor for stroke and CHD death after adjustment for sex, age, and hypertension, although the covariate factors examined were limited. 36 In addition, IGT elevated the risk of death from stroke, but not from CHD in this cohort.…”

Nonfasting Glucose and Incident Stroke and Its Types ― The Circulatory Risk in Communities Study (CIRCS) ―

“…28 However, the Hisayama study of 2,421 Japanese men and women aged 40-79 years showed that IGT by OGTT was not associated with risk of ischemic stroke or lacunar infarction. 29 A Japan Public Health Center-based prospective study (JPHC study) of 13,129 men and women aged 40-69 years using combined § Adjusted for age and sex-adjusted HR for total subjects.…”