Nonfasting Glucose and Incident Stroke and Its Types　― The Circulatory Risk in Communities Study (CIRCS) ―

Imano, Hironori; Iso, Hiroyasu; Kitamura, Akihiko; Yamagishi, Kazumasa; Hayama‐Terada, Mina; Muraki, Isao; Okada, Takeo; Umesawa, Mitsumasa; Ohira, Tetsuya; Sankai, Tomoko; Cui, Renzhe; Tanigawa, Takeshi; Kiyama, Masahiko

doi:10.1253/circj.cj-17-0950

Cited by 8 publications

(5 citation statements)

References 43 publications

(29 reference statements)

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“…Finally, 141 articles were excluded because they were animal studies (n = 9), unable to provide information (n = 120) or without a full publication (n = 12). The remaining 12 studies were enrolled in the meta‐analysis . There were 4 prospective cohort studies, 6 cross‐sectional studies and 2 with both cohort and cross‐sectional data studies .…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 12 studies were enrolled in the meta‐analysis . There were 4 prospective cohort studies, 6 cross‐sectional studies and 2 with both cohort and cross‐sectional data studies . For continuous HbA 1c , 4 cohort studies investigated different structural brain abnormalities: 2 involved white matter hyperintensities, 3 involved infarct, and 2 involved brain volume).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prediabetes and structural brain abnormalities: Evidence from observational studies

Zhou

Tang

Han

et al. 2019

Diabetes Metabolism Res

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Type 2 diabetes mellitus has been linked to structural brain abnormalities, but evidence of the association among prediabetes and structural brain abnormalities has not been systematically evaluated. Comprehensive searching strategies and relevant studies were systematically retrieved from PubMed, Embase, Medline and web of science. Twelve articles were included overall. Stratified analyses and regression analyses were performed. A total of 104 468 individuals were included.The risk of infarct was associated with continuous glycosylated haemoglobin (HbA 1c ) [adjusted odds ratio (OR) 1.19 (95% confidence interval [CI]: 1.05-1.34)], or prediabetes [adjusted OR 1.13 (95% CI: 1.00-1.27)]. The corresponding ORs associated with white matter hyperintensities were 1.08 (95%CI: 1.04-1.13) for prediabetes, and 1.10 (95%CI: 1.08-1.12) for HbA 1c . The association was significant between the decreased risk of brain volume with continuous HbA 1c (the combined OR 0.92, 95% CI: 0.87-0.98). Grey matter volume and white matter volume were inversely associated with prediabetes [weighted mean deviation (WMD), −9.65 (95%CI: −15.25 to −4.04) vs WMD, −9.25 (95%CI: −15.03 to −3.47)].There were no significant association among cerebral microbleeds, hippocampal volume, continuous total brain volume, and prediabetes. Our findings demonstrated that (a) both prediabetes and continuous HbA 1c were significantly associated with increasing risk of infarct or white matter hyperintensities; (b) continuous HbA 1c was associated with a decreased risk of brain volume; (c) prediabetes was inversely associated with grey matter volume and white matter volume. To confirm these findings, further studies on early diabetes onset and structural brain abnormalities are needed. K E Y W O R D Sglycosylated haemoglobin, meta-analysis, prediabetes, structural brain abnormalities

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prediabetes and structural brain abnormalities: Evidence from observational studies

Zhou

Tang

Han

et al. 2019

Diabetes Metabolism Res

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“…CIRCS has led to the identification of several novel risk/preventive factors for CVD: lipids (eg, serum fatty acids composition 26 , 27 and high-density lipoprotein (HDL)-cholesterol particle size 28 ), glucose tolerance (non-fasting blood glucose 29 , 30 ), other biochemical factors (serum liver/biliary tract enzymes, 31 , 32 serum homocysteine, 33 serum C-reactive protein, 34 and adiponectins 35 ), hematological factors (leukocyte counts 36 ), fibrinolytic factors (plasma fibrinogen 37 – 39 ), electrocardiographic factors (ischemic abnormalities 40 , 41 and Brugada-type electrocardiogram 42 ), other physiological factors (carotid atherosclerosis 43 and ankle-brachial blood pressure index 44 ), dietary factors (fat and protein intakes 45 ), psychosomatic factors (depressive symptoms 46 ), height, 47 snoring, 48 metabolic syndrome, 49 , 50 chronic kidney disease, 51 and subclinical end-organ damage, 52 as well as traditional risk factors (eg, alcohol, 53 – 55 smoking, 56 blood glucose/diabetes, 57 , 58 blood pressure, 1 , 5 , 11 , 59 total-, 1 , 5 , 11 LDL-, 60 non-HDL- 61 and HDL-cholesterols, 62 , 63 and triglycerides 64 , 65 ). Recent reports included risk or preventive factors for dementia, such as smoking, 66 C-reactive protein, 67 serum coenzyme Q10, 68 serum α-linoleic acid, 69 and retinal vascular changes.…”

Section: Scope and Featuresmentioning

confidence: 99%

The Circulatory Risk in Communities Study (CIRCS): A Long-Term Epidemiological Study for Lifestyle-Related Disease Among Japanese Men and Women Living in Communities

Yamagishi

Muraki

Kubota

et al. 2019

Journal of Epidemiology

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The Circulatory Risk in Communities Study (CIRCS) is an ongoing community-based epidemiological study of lifestyle-related disease involving dynamic prospective cohorts of approximately 12,000 adults from five communities of Japan: Ikawa, Ishizawa and Kita-Utetsu (Akita Prefecture), Minami-Takayasu (Osaka Prefecture), Noichi (Kochi Prefecture), and Kyowa (Ibaraki Prefecture). One of the most notable features of CIRCS is that it is not only an observational cohort study to identify risk factors for cardiovascular diseases (CVD), such as stroke, coronary heart disease, and sudden cardiac death, but it also involves prevention programs for CVD. Using basic, clinical, epidemiological, and statistical techniques, CIRCS has clarified characteristics of CVD and the related risk factors to develop specific methodologies towards CVD prevention in Japanese middle-aged or older adults for more than half a century.

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“…Brain structural abnormalities are considered to be an important pathway for brain diseases caused by type-2 DM. While previous studies have confirmed that type-2 DM is related to an increased risk of structural brain abnormalities such as LIs (8,9) and brain atrophy (9)(10)(11)(12), findings on the relationship between type-2 DM and the markers of small-vessel diseases such as WMH (13)(14)(15)(16)(17) and cerebral microbleeds (18)(19)(20)(21)(22) have not been consistent. Some findings suggest that no difference in periventricular WMHs between patients with and without diabetes mellitus.…”

Section: Introductionmentioning

confidence: 79%

Clinical and MRI features about two types of silent cerebral small-vessel disease in type-2 diabetes mellitus: a retrospective cross-sectional study in a tertiary hospital

Wang¹,

Wang²,

Xia³

et al. 2022

Quant Imaging Med Surg

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Background: The present study aimed to evaluate the frequency of silent cerebral small-vessel disease, especially lacunes and white matter hyperintensities, in patients with or without the impaired glucose tolerance (IGT) and type-2 diabetes mellitus, and to characterize the diabetes-correlated factors related to silent cerebral small-vessel disease.Methods: This is a retrospective cross-sectional study. Totally 698 patients were included in this study, from January 2014 to December 2019, among which 270 patients were included in the diabetes mellitus group, 106 patients were included in the IGT group, and 322 patients were included in the Control group.All patients underwent magnetic resonance imaging to investigate the silent cerebral small-vessel disease: the lacunes and the white matter hyperintensities. All the baseline information and diabetes-related factors, such as glycated hemoglobin level, insulin usage, etc., were collected. Then correlation analysis and regression analysis were used to explore the correlation between diabetes with related risk factors and silent cerebral small-vessel disease.Results: Lacunes and white matter hyperintensities were more common in the diabetes mellitus group than in the IGT group and the Control group, with an occurrence of lacunes of 83.3% vs. 70.8% vs. 70.4% (P=0.003), respectively, and an occurrence of white matter hyperintensities of 41.1% vs. 24.5% vs. 31.1% (P=0.003), respectively. The occurrence of lacunes was correlated with the duration of diabetes mellitus {odds ratio [OR] =1.483, 95% confidence interval (CI): 1.082, 2.031, P=0.009} and the age (OR =1.141, 95% CI:1.102, 1.180, P<0.001), while white matter hyperintensities were independently correlated only with the age (OR =1.124, 95% CI: 1.094, 1.155, P<0.001).Conclusions: Lacunes and white matter hyperintensities, are more common in the diabetes mellitus patients than in the IGT patients or in the other patients. The occurrence of lacunes was correlated with the duration of diabetes mellitus and the age, while the occurrence of white matter hyperintensities was independently correlated with the age.

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Nonfasting Glucose and Incident Stroke and Its Types　― The Circulatory Risk in Communities Study (CIRCS) ―

Cited by 8 publications

References 43 publications

Prediabetes and structural brain abnormalities: Evidence from observational studies

Prediabetes and structural brain abnormalities: Evidence from observational studies

The Circulatory Risk in Communities Study (CIRCS): A Long-Term Epidemiological Study for Lifestyle-Related Disease Among Japanese Men and Women Living in Communities

Clinical and MRI features about two types of silent cerebral small-vessel disease in type-2 diabetes mellitus: a retrospective cross-sectional study in a tertiary hospital

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Nonfasting Glucose and Incident Stroke and Its Types ― The Circulatory Risk in Communities Study (CIRCS) ―

Cited by 8 publications

References 43 publications

Prediabetes and structural brain abnormalities: Evidence from observational studies

Prediabetes and structural brain abnormalities: Evidence from observational studies

The Circulatory Risk in Communities Study (CIRCS): A Long-Term Epidemiological Study for Lifestyle-Related Disease Among Japanese Men and Women Living in Communities

Clinical and MRI features about two types of silent cerebral small-vessel disease in type-2 diabetes mellitus: a retrospective cross-sectional study in a tertiary hospital

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Product

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Nonfasting Glucose and Incident Stroke and Its Types　― The Circulatory Risk in Communities Study (CIRCS) ―