Impaired functional connectivity of limbic system in migraine without aura

Wei, Heng-Le; Chen, Yu‐Chen; Yu, Yu-Sheng; Zhou, Gang-Ping; Qu, Li-Jie; Yin, Xindao; Li, Junrong; Zhang, Hong

doi:10.1007/s11682-019-00116-5

Cited by 39 publications

(47 citation statements)

References 57 publications

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“…Various studies have previously illustrated structural and functional alterations of the occipital cortex in patients with migraine (22,(53)(54)(55), which are generally thought to be associated with the aura phenomenon, especially visual aura (56). Interestingly, these significant structural and functional alterations of the occipital cortex were also observed in patients with MWoA (57)(58)(59)(60)(61)(62). For example, in our recent study (61), a strong positive dynamic connectivity within the visual cortex and the significantly negative dynamic connectivity between middle occipital gyrus and posterior thalamus were found in MWoA patients.…”

Section: Discussionmentioning

confidence: 94%

The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

et al. 2020

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Section: Discussionmentioning

confidence: 94%

The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

et al. 2020

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“…Stress-related symptoms accompanying the headache, such as reactions of the autonomic nervous system as well as cognitive and attentional deficits, have been linked to limbic processes ( 40–42 ). Limbic alterations are further related to migraine-related disabilities ( 39 ), increased pain during attacks ( 38 ) and the severity of the disease ( 37, 43 ). These findings offer the opportunity to tailor migraine treatments specifically to limbic functions.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, hypometabolism of limbic areas, particularly the insula, cingulate and prefrontal cortices, was observed during the pain-free interval, compared to healthy controls (37) . Other studies observed an altered functional connectivity between the hippocampus, insula, amygdala, and pain-modulating and encoding areas during (21,38) and outside of migraine attacks (39) .…”

Section: Trajectory Of the Cerebral Blood Flow Over The Migraine Cyclementioning

confidence: 91%

Migraine Attacks as a Result of Hypothalamic Loss of Control

Stankewitz

Keidel

Rehm

et al. 2020

Preprint

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To assess the natural trajectory of brain activity over the migraine cycle, we assessed (1) the cerebral perfusion and (2) the hypothalamic connectivity during spontaneous headache attacks with follow-up recordings towards the next migraine attack. Using pseudo-continuous arterial spin labelling and resting-state functional magnetic resonance imaging, 12 migraine patients were examined in 82 sessions. We detected cyclic changes of brain perfusion in the limbic circuit (insula, hippocampus, and nucleus accumbens), with the highest perfusion during headache attacks. In addition, we found an increase of hypothalamic connectivity to the limbic system over the interictal interval, then collapsing during the headache. Our data provide strong evidence for the predominant role of the hypothalamus as a zeitgeber for generating migraine attacks. Our findings suggest that migraine attacks are the result of the hypothalamus losing control over the limbic system.

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“…A meta-analysis of excitatory primary motor cortex (M1) stimulation showed significant effects on reducing headache intensity and frequency of headache attacks in patients with migraine with a large effect size [11]. Migraine without aura showed decreased functional connectivity between the left hippocampus and contralateral SMA and bilateral inferior parietal gyri (IPG) [12]. Patients with a higher frequency of migraine attacks showed increased periaqueductal gray matter (PAG) connectivity with the S1 face representation area and the SMA, an area involved in pain expectancy [13].…”

Section: Introductionmentioning

confidence: 99%

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura

Qin

et al. 2020

J Headache Pain

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Background: Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information processing and sensorimotor integration. The altered functional connectivity of sub-regions of sensorimotor brain areas with other brain cortex associated with migraine needs further investigation. Methods: Forty-eight migraineurs without aura during the interictal phase and 48 age-and sex-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. We utilized seed-based functional connectivity analysis to investigate whether patients exhibited abnormal functional connectivity between subregions of sensorimotor brain areas and cortex regions. Results: We found that patients with migraineurs without aura exhibited disrupted functional connectivities between the sensorimotor areas and the visual cortex, temporal cortex, posterior parietal lobule, prefrontal areas, precuneus, cingulate gyrus, sensorimotor areas proper and cerebellum areas compared with healthy controls. In addition, the clinical data of the patients, such as disease duration, pain intensity and HIT-6 score, were negatively correlated with these impaired functional connectivities. Conclusion: In patients with migraineurs without aura, the functional connectivities between the sensorimotor brain areas and other brain regions was reduced. These disrupted functional connectivities might contribute to abnormalities in visual processing, multisensory integration, nociception processing, spatial attention and intention and dysfunction in cognitive evaluation and modulation of pain. Recurrent headache attacks might lead to the disrupted network between primary motor cortex and temporal regions and between primary somatosensory cortex and temporal regions. Pain sensitivity and patient quality of life are closely tied to the abnormal functional connectivity between sensorimotor regions and other brain areas.

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Impaired functional connectivity of limbic system in migraine without aura

Cited by 39 publications

References 57 publications

The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

Migraine Attacks as a Result of Hypothalamic Loss of Control

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura

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