The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

Yin, Tao; Sun, Guojuan; Tian, Zilei; Liu, Mailan; Gao, Yujie; Dong, Mingkai; Wu, Fengpeng; Li, Zhengjie; Liang, Fanrong; Zeng, Fang; Lan, Lei

doi:10.3389/fneur.2020.588207

Cited by 37 publications

(51 citation statements)

References 78 publications

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“…Twenty studies (71%) focused on the long-term efficacy of acupuncture for migraine [ 6 – 8 , 11 , 13 , 15 – 17 , 20 , 22 – 25 , 27 – 33 ]; eight studies (29%) adopted performed treatment session to explore the immediate efficacy of acupuncture for migraine [ 9 , 10 , 12 , 14 , 18 , 19 , 21 , 26 ] ( Figure1(b) ).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-one (75%) studies were designed to concentrate on the central mechanisms of acupuncture for migraine. Among them, nine studies (32%) were designed as the self-control model (pre vs. posttreatment) [ 9 , 10 , 15 , 18 – 21 , 28 , 29 ], nine studies (32%) explored the differences in cerebral responses between verum acupuncture (VA) and sham acupuncture (SA) [ 6 – 8 , 12 , 13 , 16 , 26 , 27 , 33 ], and the remaining three studies for different acupuncture intensities or different acupoints. Other studies concentrated on the central mechanisms of acupuncture for different conditions of migraine ( Figure1(d) ).…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies used the visual analogue scale (VAS) to assess the pain intensity of migraine [ 6 – 8 , 11 – 15 , 17 , 20 , 22 – 24 , 27 – 29 , 33 ]. Besides, the condition of migraine such as frequency of migraine attacks (8 studies) [ 6 – 8 , 11 , 13 , 16 , 20 , 29 ], migraine attack duration (7 studies) [ 20 , 22 – 24 , 28 , 30 , 31 ], migraine days (6 studies) [ 11 , 15 , 22 – 24 , 29 ], and migraine intensity (3 studies) [ 13 , 30 , 31 ] was also assessed. Two studies adopted the disease-specific scale, Migraine-Specific Quality of Life Questionnaire (MSQ), to evaluate the QoL of migraine [ 22 , 25 ] ( Figure1(c) ).…”

Section: Resultsmentioning

confidence: 99%

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A Narrative Review of Neuroimaging Studies in Acupuncture for Migraine

Dong

et al. 2021

Pain Research and Management

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Acupuncture has been widely used as an alternative and complementary therapy for migraine. With the development of neuroimaging techniques, the central mechanism of acupuncture for migraine has gained increasing attention. This review aimed to analyze the study design and main findings of neuroimaging studies of acupuncture for migraine to provide the reference for future research. The original studies were collected and screened in three English databases (PubMed, Embase, and Cochrane Library) and four Chinese databases (Chinese National Knowledge Infrastructure, Chinese Biomedical Literature database, the Chongqing VIP database, and Wanfang database). As a result, a total of 28 articles were included. Functional magnetic resonance imaging was the most used neuroimaging technique to explore the cerebral activities of acupuncture for migraine. This review manifested that acupuncture could elicit cerebral responses on patients with migraine, different from sham acupuncture. The results indicated that the pain systems, including the medial pain pathway, lateral pain pathway, and descending pain modulatory system, participated in the modulation of the cerebral activities of migraine by acupuncture.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A Narrative Review of Neuroimaging Studies in Acupuncture for Migraine

Dong

et al. 2021

Pain Research and Management

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“…The abnormal activation of the painful, olfactory, and visual stimulation present in migraineurs is widely recognized. These features set migraine apart from other neurological disorders and help improve diagnosis accuracy ( Tu et al, 2020 ) and predict treatment efficacy ( Yin et al, 2020 ). Therefore, “a pain processing network” offered a holistic perspective compared with “a separate migraine generator” on migraine research.…”

Section: Introductionmentioning

confidence: 99%

The Altered Functional Connectivity With Pain Features Integration and Interaction in Migraine Without Aura

et al. 2021

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IntroductionMigraine without aura (MwoA) is a primary type of migraine, a common disabling disorder, and a disabling neurological condition. The headache is a complex experience, a common form of pain, in which multiple sensory information dimensions are combined to provide a unified conscious event. Migraine ictal have unique neuroimage biomarkers, but the brain is also affected during the inter-ictal phase. According to the current studies, a hypothesis was constructed that the altered integration of pain spatial and intensity information impacts headache intensity in the inter-ictal period.MethodsIn this study, we applied theory-based region-to-region functional connectivity (FC) analyses to compare the differences in resting-state FC between MwoA participants and healthy controls with the pain integration hypothesis. After the correlation matrices between FC edges and clinical symptoms were constructed, the moderating effect and simple slope tests were investigated to explain whether and how the dysfunction of pain features discrimination affects the clinical symptoms.ResultsFunctional connectivity analyses showed significantly decreased FC edges between the left dorsolateral superior frontal gyrus (SFGdor) and left insula, and an increased FC edge between the left SFGdor and bilateral angular gyrus. The correlation matrix showed no significant correlation between significantly altered FC edge and headache duration, frequency, Zung self-rating anxiety scale, and Zung self-rating depression scale. Only one significantly altered edge in the MwoA condition was significantly correlated with headache intensity. Moderating Module 1 and 2 manifested the moderator variable (altered rs-FC edge) moderated the link between the normal edges and headache intensity.ConclusionThe pain features integration processes in migraineurs vary from HCs, related to the clinical symptoms during a migraine attack. Moreover, the clinical symptoms will be affected by one or more discrimination modules. And the spatial or intensity discrimination modules have a higher impact when combined with another module on clinical symptoms than the single module.

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“…Similarly, migraine patients showed signi cant neural activation in the lingual gyrus (LG), cuneus and precuneus after exposure to negative affective stimuli [11]. Furthermore, Yin et al reported that the spontaneous activity pattern of the visual cortex may predict the therapeutic e cacy of acupuncture in patients suffering from migraine [12]. However, it is still unclear whether there is a relationship between changes in functional characteristics and psychiatric disorders in episodic migraine patients with or without anxiety.…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity of the Visual Cortex Differentiates Anxiety Comorbidity From Episodic Migraineurs Without Aura

Wei

Guo

et al. 2021

Preprint

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Background: Migraine is a common neurological disease that is often accompanied by psychiatric comorbidities. However, the relationship between abnormal brain function and psychiatric comorbidities in migraine patients remains largely unclear. Therefore, the present study sought to explore the correlations between the resting-state functional deficits and psychiatric comorbidities in migraine without aura (MwoA) patients.Methods: Resting-state functional magnetic resonance images were obtained. In addition, the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values were obtained. Thereafter regional abnormalities in MwoA patients with and without anxiety (MwoA-A and MwoA-OA) were chosen as seeds to conduct functional connectivity (FC) analysis.Results: Compared to the healthy controls (HCs), the MwoA-A and MwoA-OA patients had abnormal ALFF and ReHo values in the right lingual gyrus (LG). They also had abnormal FC of the right LG with the ipsilateral superior frontal gyrus (SFG) and middle cingulate cortex (MCC). Additionally, the MwoA-A patients showed higher ReHo values in the left posterior intraparietal sulcus (pIPS) and abnormal FC of the right LG with ipsilateral pIPS and primary visual cortex, compared to the MwoA-OA patients. Moreover, the MwoA-OA patients showed an increase in the FC with the right posterior cingulate cortex/precuneus (PCC/PCUN), left middle frontal gyrus (MFG) and left inferior temporal gyrus (ITG) relative to the HCs. Furthermore, the ALFF values of the right LG positively were correlated with anxiety scores in MwoA-A patients. The abnormal LG-related FCs with the PCC/PCUN, MFG and ITG were negatively associated with the frequency of headaches in MwoA-OA patients.Conclusions: This study identified abnormal visual FC along with other core networks differentiating anxiety comorbidity from MwoA. This may therefore enhance the understanding of the neuropsychological basis of psychiatric comorbidities and provide novel insights that may help in the discovery of new marks or even treatment targets.

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The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

Cited by 37 publications

References 78 publications

A Narrative Review of Neuroimaging Studies in Acupuncture for Migraine

A Narrative Review of Neuroimaging Studies in Acupuncture for Migraine

The Altered Functional Connectivity With Pain Features Integration and Interaction in Migraine Without Aura

Functional Connectivity of the Visual Cortex Differentiates Anxiety Comorbidity From Episodic Migraineurs Without Aura

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