IMPAIRED FIBRINOLYTIC RESPONSE TO EXERCISE IN PATIENTS WITH TYPE-IV HYPERLIPOPROTEINqMIA

Epstein, S E; Brakman, Pieter; Rosing, D.; Redwood, David R.; Astrup, Tage

doi:10.1016/s0140-6736(70)91399-1

Cited by 69 publications

(21 citation statements)

References 14 publications

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“…Moreover, assaying only basal levels of fibrinolytic activity does not test the capacity of the fibrinolytic system to respond to stress. Our finding of a defective diurnal rise extends the results of a previous investigation (15) demonstrating that seven of eight subjects with type IV hyperlipoproteinemia had an impaired fibrinolytic response to exercise. Thus, these observations suggest that the accelerated development of coronary artery disease in subjects with type IV hyperlipoproteinemia may be related not only to the increased plasma levels of triglycerides but also to a coexisting defect in the responsiveness of the fibrinolytic system.…”

Section: Discussionsupporting

confidence: 89%

“…Thus, these observations suggest that the accelerated development of coronary artery disease in subjects with type IV hyperlipoproteinemia may be related not only to the increased plasma levels of triglycerides but also to a coexisting defect in the responsiveness of the fibrinolytic system. The majority of subjects with type IV hyperlipoproteinemia demonstrated both an impaired fibrinolytic response to exercise (15) and an impaired diurnal fibrinolytic increase. In contrast, although nearly half of the older normal subjects showed an impaired diurnal fibrinolytic increase, a previous study demonstrated that the fibrinolytic response to exercise was normal in six of seven older normal subjects (15).…”

Section: Discussionmentioning

confidence: 99%

“…Also, fibrinolytic activity usually has been assayed using single blood 752 samples obtained from subjects at rest. Such a procedure is an insensitive means of assessing the integrity of the blood fibrinolytic system, since abnormalities in the response of the system may be detectable only when the system is stressed (15). Although under ordinary circumstances intense exercise constitutes a desirable means of testing the capacity of the blood fibrinolytic system (15), this type of stress is impractical for subjects with coronary artery disease.…”

mentioning

confidence: 99%

“…Such a procedure is an insensitive means of assessing the integrity of the blood fibrinolytic system, since abnormalities in the response of the system may be detectable only when the system is stressed (15). Although under ordinary circumstances intense exercise constitutes a desirable means of testing the capacity of the blood fibrinolytic system (15), this type of stress is impractical for subjects with coronary artery disease. However, the diumal fluctuations of fibrinolytic activity normally occurring in man (1&-17) and presumably representing a response to internal, physiological stimuli, also provide an index of the functional capacity of the fibrinolytic system.…”

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confidence: 99%

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Impairment of the Diurnal Fibrinolytic Response in Man

Rosing¹,

Redwood²,

Brakman³

et al. 1973

Circulation Research

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Diurnal patterns of plasma euglobulin fibrinolytic activity, estimated by the fibrin plate method, were determined in groups of young normal and older normal subjects, in subjects with type IV hyperlipoproteinemia, and in subjects with coronary artery disease who had normal lipid profiles. The marked diumal increases in fibrinolytic activity observed in the young normal subjects were significantly reduced in a large percent of the older normal subjects and in most of the subjects with coronary artery disease or type IV hyperlipoproteinemia. Although not conclusive, these findings were compatible with the hypothesis that an impairment in the responsiveness of the fibrinolytic system may be related to the development of coronary artery disease.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Impairment of the Diurnal Fibrinolytic Response in Man

Rosing¹,

Redwood²,

Brakman³

et al. 1973

Circulation Research

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show abstract

“…37 It is therefore possible that nephrotic individuals who are sedentary and frequently hyperlipidemic could have similar reductions in the release of plasminogen activator. One preliminary study documented such a deficient activator release after venous occlusion in nephrotic patients.…”

Section: Fibrinolysismentioning

confidence: 99%