Impaired Face Perception in Individuals with Autism Spectrum Disorder: Insights on Diagnosis and Treatment

Bi, Taiyong; Fang, Fang

doi:10.1007/s12264-017-0187-1

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…Specifically, ASD individuals show substantial deficits in face perception (Grelotti, Gauthier, & Schultz, 2002), owing to abnormal face processing strategies (Hobson, Ouston, & Lee, 1988), possibly caused by perceptual abnormalities, such as a locally oriented rather than global visual analysis (Morin et al., 2015), or more complex alterations of the social brain network (Pelphrey, Yang, & McPartland, 2014; Schultz et al., 2003). Impaired face perception could also underpin social interaction difficulties (Bi & Fang, 2017). Several studies (Dawson, Webb, & McPartland, 2005; Harms, Martin, & Wallace, 2010; Hileman, Henderson, Mundy, Newell, & Jaime, 2011) suggested that, compared to developmentally typical individuals, ASD individuals show reduced accuracy and longer reaction times for identity or expression recognition.…”

Section: Introductionmentioning

confidence: 99%

Brain activity during facial processing in autism spectrum disorder: an activation likelihood estimation (ALE) meta‐analysis of neuroimaging studies

Costa

Cristea

Bò

et al. 2021

Child Psychology Psychiatry

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Background Though aberrant face processing is a hallmark of autistic spectrum disorder (ASD), findings on accompanying brain activity are divergent. Therefore, we conducted an activation likelihood estimation (ALE) meta‐analysis of studies examining brain activity during face processing. Methods We searched PubMed and PsycINFO using combinations of terms as ‘fMRI’, ‘Autism Spectrum Disorder’, ‘Face Perception’. Eligible studies reported on DSM‐diagnosed ASD individuals, compared to controls (HC), using face stimuli presented in fMRI and reporting whole‐brain analysis coordinates. We compared two approaches: ‘convergence of differences’ (primary analysis) using study‐level coordinates from ASD vs. HC contrasts, and ‘differences in convergence’ (secondary) pooling coordinates within each group separately, and contrasting the resultant ALE maps. Results Thirty‐five studies (655 ASD and 668 HC) were included. Primary analysis identified a cluster in amygdala/parahippocampus where HC showed greater convergence of activation. Secondary analysis yielded no significant results. Conclusions Results suggest that ASD dysfunction in face processing relies on structures involved in emotional processing rather than perception. We also demonstrate that the two ALE methodologies lead to divergent results.

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Section: Introductionmentioning

confidence: 99%

Brain activity during facial processing in autism spectrum disorder: an activation likelihood estimation (ALE) meta‐analysis of neuroimaging studies

Costa

Cristea

Bò

et al. 2021

Child Psychology Psychiatry

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“…The dorsolateral prefrontal cortex (DLPFC) is considered to play a crucial role in many high-level functions, such as working memory, decision-making, and self-control [ 1 – 4 ]. In addition, increasing numbers of studies have demonstrated that the DLPFC is also involved in normal and abnormal emotion-related brain networks, along with the amygdala and other subcortical structures [ 5 , 6 ]. Pleasant words induce more activity in the bilateral DLPFC than unpleasant words [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Anodal Transcranial Direct-Current Stimulation Over the Right Dorsolateral Prefrontal Cortex Influences Emotional Face Perception

Yang

Ren

2018

Neurosci. Bull.

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The dorsolateral prefrontal cortex (DLPFC) is considered to play a crucial role in many high-level functions, such as cognitive control and emotional regulation. Many studies have reported that the DLPFC can be activated during the processing of emotional information in tasks requiring working memory. However, it is still not clear whether modulating the activity of the DLPFC influences emotional perception in a detection task. In the present study, using transcranial direct-current stimulation (tDCS), we investigated (1) whether modulating the right DLPFC influences emotional face processing in a detection task, and (2) whether the DLPFC plays equal roles in processing positive and negative emotional faces. The results showed that anodal tDCS over the right DLPFC specifically facilitated the perception of positive faces, but did not influence the processing of negative faces. In addition, anodal tDCS over the right primary visual cortex enhanced performance in the detection task regardless of emotional valence. Our findings suggest, for the first time, that modulating the right DLPFC influences emotional face perception, especially faces showing positive emotion.

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“…Substantial research indicates abnormalities in the way individuals with ASD perceive social stimuli, including faces and emotions. Commonly described deficits include reduced eye contact, abnormal gaze following, and poor orientation to faces (Klin et al, 2002;Webb et al, 2017), together with impairments in discrimination, recognition, and memory for faces and emotions (Bi & Fang, 2017;Dawson et al, 2005;Nomi & Uddin, 2015;Vlamings et al, 2010). However, akin to EF and weak central coherence theories, these observations are not universal.…”

Section: Low-level Social Cognitive Skills: Social Perceptionmentioning

confidence: 99%

Social cognition in autism spectrum disorder and neurogenetic syndromes

Maier¹,

Ryan²,

Chisholm³

et al. 2021

Clinical Disorders of Social Cognition

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Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterised by impairing social communication deficits and restricted and repetitive behaviours. Over the past few decades, a growing body of research has proposed that social cognitive deficits are a key psychological driver of ASD. In the following chapter, we review evidence for this and show that while social cognitive deficits are common in individuals with ASD, they do not hold clear relationships with ASD symptoms, and are not necessary nor sufficient for a diagnosis of ASD. We consider several reasons for this, including the heterogeneity inherent within individuals with ASD, at the symptom, cognitive and aetiological levels. We then discuss the utility of examining ASD and social cognition within syndromic ASD populations which reduce the heterogeneity in the idiopathic population and can be thought of as human 'genetic models' of ASD. These syndromic cases of ASD offer a valuable opportunity to elucidate the neurobiological and developmental pathways that lead to both ASD symptoms and aberrant social cognitive processing that are due to a single gene mutation. The possibility of this research to translate into targeted treatments is also explored.

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Impaired Face Perception in Individuals with Autism Spectrum Disorder: Insights on Diagnosis and Treatment

Cited by 10 publications

References 22 publications

Brain activity during facial processing in autism spectrum disorder: an activation likelihood estimation (ALE) meta‐analysis of neuroimaging studies

Brain activity during facial processing in autism spectrum disorder: an activation likelihood estimation (ALE) meta‐analysis of neuroimaging studies

Anodal Transcranial Direct-Current Stimulation Over the Right Dorsolateral Prefrontal Cortex Influences Emotional Face Perception

Social cognition in autism spectrum disorder and neurogenetic syndromes

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