Impaired Ethanol Metabolism with Advancing Age

Hahn, Henry K. J.; Burch, Robert E.

doi:10.1111/j.1530-0277.1983.tb05464.x

Cited by 35 publications

(14 citation statements)

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“…We found, as did Ott et al (1985) in F-344 rats and Ritzmann and Springer (1980) in mice, that the BECs of old animals produced by IP injection were slower to rise and never reached the peak BECs observed in young animals. Although others (Abel and York 1979;Hahn and Burch 1983) reported peak BECs to be higher in older animals, they used a different rat strain (Sprague-Dawley), which is known for gaining weight and body fat with age (Ott et al 1985). The larger quantity of body fat that has been observed in aging Sprague-Dawley rats provides a relatively smaller volume of body fluids for the distribution of EtOH and results in higher BECs in aging rats when EtOH doses are administered by body weight (Ott et al 1985).…”

Section: Discussionmentioning

confidence: 98%

Effects of route of administration of ethanol on high-speed reaction time in young and old rats

et al. 1989

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The blood ethanol concentrations (BECs) and reactive capacity of young (8 months) and old (24 months) male Fischer 344 rats were compared at 5, 10, 20, 45, 65, and 90 min following the administration of ethanol (EtOH). The time-dependent effects of intragastric intubation (IG; 3 g/kg) and intraperitoneal injection (IP; 1.5 g/kg) of EtOH (20% w/v) were determined. Subsequent to IG delivery, BECs rose most rapidly within the first 20 min, but did not reach peak levels until 90 min for both young (240 mg/dl) and old rats (250 mg/dl). Following IP injections, BECs escalated within 5 min to 250 mg/dl in the young, to 175 mg/dl in the old, and declined gradually to a stabilized value of 150 mg/dl (young) and 130 mg/dl (old). The old rats never achieved the high BECs seen in the young. Reactive capacity, a measure of auditory/visual reaction time, was inversely related to BECs. As BECs (IP) declined, performance improved at a similar rate in both age groups, although the old rats' performance was more impaired than that of the young. However, BEC per se was not an adequate predictor of reactive capacity. When EtOH was delivered by IG so that BECs remained high for long periods of time, reactive capacity was far less impaired compared with IP delivery in which comparable BECs were present for only a few minutes. The possibility was noted that behavioral tolerance may have developed during the 90-min post-EtOH period, and that the IP delivery method may disrupt behavior in ways independent of brain ethanol levels.

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Section: Discussionmentioning

confidence: 98%

Effects of route of administration of ethanol on high-speed reaction time in young and old rats

et al. 1989

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“…It has been known that ethanol metabolism is decreased with age increase (Hahn and Burch, 1983;Gellert et al, 1987;Seitz et al, 1989Seitz et al, , 1992Lucey et al, 1999). Physiological or biochemical changes accompanied with age increase such as decreases in liver size, body water, and ADH activity were proposed as the underlying mechanisms for the age-dependent reduction in ethanol metabolism.…”

Section: Introductionmentioning

confidence: 98%

Effect of age increase on metabolism and toxicity of ethanol in female rats

Kim

Sohn

2003

Life Sciences

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“…The magnitude of this problem is compounded by the rapidly increasing proportion of the population represented by the elderly [5]. In addition, sensitivity of elderly subjects to the toxic effects of EtOH appears to be enhanced compared to younger persons [6][7][8][9]. Laboratory animal studies have also indicated that ethanol metabolism is decreased and toxicity increased with advancing age [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Glutathione depletion and recovery after acute ethanol administration in the aging mouse

Vogt

Richie

2007

Biochemical Pharmacology

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Glutathione (GSH) plays an important role in the detoxification of ethanol (EtOH) and acute EtOH administration leads to GSH depletion in the liver and other tissues. Aging is also associated with a progressive decline in GSH levels and impairment in GSH biosynthesis in many tissues. Thus, the present study was designed to examine the effects of aging on EtOH-induced depletion and recovery of GSH in different tissues of the C57Bl/6NNIA mouse. EtOH (2-5 g/kg) or saline was administered i.p. to mice of ages 6 mo (young), 12 mo (mature), and 24 mo (old); and GSH and cyst(e)ine concentrations were measured 0-24 hours thereafter. EtOH administration (5g/kg) depleted hepatic GSH levels >50% by 6 hr in all animals. By 24 hr, levels remained low in both young and old mice, but recovered to baseline levels in mature mice. At 6 hr, the decrease in hepatic GSH was dosedependent up to 3 g/kg EtOH, but not at higher doses. The extent of depletion at the 3 g/kg dose was dependent upon age, with old mice demonstrating significantly lower GSH levels than mature mice (P<0.001). Altogether these results indicate that aging was associated with a greater degree of EtOH and fasting-induced GSH depletion and subsequent impaired recovery in liver. An impaired ability to recover was also observed in young animals. Further studies are required to determine if an inability to recover from GSH depletion by EtOH is associated with enhanced toxicity.

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Impaired Ethanol Metabolism with Advancing Age

Cited by 35 publications

References 10 publications

Effects of route of administration of ethanol on high-speed reaction time in young and old rats

Effects of route of administration of ethanol on high-speed reaction time in young and old rats

Effect of age increase on metabolism and toxicity of ethanol in female rats

Glutathione depletion and recovery after acute ethanol administration in the aging mouse

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