Effect of age increase on metabolism and toxicity of ethanol in female rats

Kim, Young C.; Kim, Sung Young; Sohn, Young R

doi:10.1016/j.lfs.2003.07.009

Cited by 24 publications

(16 citation statements)

References 40 publications

(45 reference statements)

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“…Older mothers are more likely to drink during pregnancy than younger mothers, although binge drinking is more common among younger mothers [18,19,[116][117][118]. Blood alcohol concentration (BAC) per unit dose increases with age, leading to higher levels of exposure per unit consumed among the offspring of older mothers [120][121][122][123]. Higher BACs may be partly explained by age-related changes in body composition including an increased body-fat-to-water ratio among older individuals [120,[122][123][124].…”

Section: Maternal Agementioning

confidence: 99%

The causal web of foetal alcohol spectrum disorders: a review and causal diagram

McQuire

Daniel

Hurt

et al. 2019

Eur Child Adolesc Psychiatry

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Foetal alcohol spectrum disorders (FASDs) are a leading cause of developmental disability. Prenatal alcohol use is the sole necessary cause of FASD, but it is not always sufficient. Multiple factors influence a child's susceptibility to FASD following prenatal alcohol exposure. Much of the FASD risk factor literature has been limited to discussions of association, rather than causation. While knowledge of predictor variables is important for identifying who is most at risk of FASD and for targeting interventions, causal knowledge is important for identifying effective mechanisms for prevention and intervention programmes. We conducted a systematic search and narrative synthesis of the evidence and used this to create a causal diagram (directed acyclic graph; DAG) to describe the causal pathways to FASD. Our results show that the aetiology of FASD is multifaceted and complex. FASD risk is determined by a range of lifestyle, sociodemographic, maternal, social, gestational, and genetic factors. The causal diagram that we present in this review provides a comprehensive summary of causal risk factors for FASD and can be used as a tool to inform data collection and statistical modelling strategies to minimise bias in future studies of FASD.

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Section: Maternal Agementioning

confidence: 99%

The causal web of foetal alcohol spectrum disorders: a review and causal diagram

McQuire

Daniel

Hurt

et al. 2019

Eur Child Adolesc Psychiatry

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“…Such an age-related increase in BAC might be predicted if alcohol clearance is decreased by aging. However, results from pharmacokinetic studies on ethanol metabolism in rats are conflicting (31,46), thereby rendering any conclusion equivocal. We can also not exclude the possibility that an alcohol-and/or aging-induced decrease in spontaneous physical activity did not contribute, in part, to the observed muscle phenotype.…”

Section: R892 Aging Alcohol and Muscle Protein Balancementioning

confidence: 99%

Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius

Korzick

Sharda

Pruznak

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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The present study sought to determine whether the protein catabolic response in skeletal muscle produced by chronic alcohol feeding was exaggerated in aged rats. Adult (3 mo) and aged (18 mo) female F344 rats were fed a nutritionally complete liquid diet containing alcohol (36% of total calories) or an isocaloric isonitrogenous control diet for 20 wk. Muscle (gastrocnemius) protein synthesis, as well as mTOR and proteasome activity did not differ between control-fed adult and aged rats, despite the increased TNF-α and IL-6 mRNA and decreased IGF-I mRNA in muscle of aged rats. Compared with alcohol-fed adult rats, aged rats demonstrated an exaggerated alcohol-induced reduction in lean body mass and protein synthesis (both sarcoplasmic and myofibrillar) in gastrocnemius. Alcohol-fed aged rats had enhanced dephosphorylation of 4E-BP1, as well as enhanced binding of raptor with both mTOR and Deptor, and a decreased binding of raptor with 4E-BP1. Alcohol feeding of both adult and aged rats reduced RagA binding to raptor. The LKB1-AMPK-REDD1 pathway was upregulated in gastrocnemius from alcohol-fed aged rats. These exaggerated alcohol-induced effects in aged rats were associated with a greater decrease in muscle but not circulating IGF-I, but no further increase in inflammatory mediators. In contrast, alcohol did not exaggerate the age-induced increase in atrogin-1 and MuRF1 mRNA or the increased proteasome activity. Our results demonstrate that, compared with adult rats, the gastrocnemius from aged rats is more sensitive to the catabolic effects of alcohol on protein synthesis, but not protein degradation, and this exaggerated response may be AMPK-dependent.

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“…14,15) The goal of the present study was to determine the impact of certain probiotics, green tea extract (GTE) and its fermented product with Lactobacillus fermentum strain OCS19, on alcohol-induced toxicity and liver injury, both in vitro and in vivo.…”

Section: )mentioning

confidence: 99%

Green Tea Extract (Camellia sinensis) Fermented byLactobacillus fermentumAttenuates Alcohol-Induced Liver Damage

Park

Kim

2012

Bioscience, Biotechnology, and Biochemistry

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Effect of age increase on metabolism and toxicity of ethanol in female rats

Cited by 24 publications

References 40 publications

The causal web of foetal alcohol spectrum disorders: a review and causal diagram

The causal web of foetal alcohol spectrum disorders: a review and causal diagram

Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius

Green Tea Extract (Camellia sinensis) Fermented byLactobacillus fermentumAttenuates Alcohol-Induced Liver Damage

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