Impaired endothelium-dependent vasodilation in type 2 diabetes. Relation to LDL size, oxidized LDL, and antioxidants.

Mäkimattila, Sari; Liu, Ming-Lin; Vakkilainen, Juha; Schlenzka, A; Lahdenperä, Sanni; Syvänne, Mikko; Mäntysaari, Matti; Summanen, Paula; Bergholm, Robert; Taskinen, Marja‐Riitta; Yki‐Järvinen, Hannele

doi:10.2337/diacare.22.6.973

Cited by 149 publications

(98 citation statements)

References 8 publications

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“…We recently performed a comprehensive search for such factors and found LDL size to be weakly correlated with endothelium-dependent vasodilatation. 34 A similar relation was also described by Watts et al 11 within a group of type 2 diabetic patients. In other studies, 8,12,13 no significant correlations between cardiovascular risk factors and endothelium-dependent vasodilatation have been identified.…”

Section: Vehkavaara Et Al Insulin Therapy and Endothelial Functionsupporting

confidence: 63%

Insulin Therapy Improves Endothelial Function in Type 2 Diabetes

Vehkavaara¹,

Mäkimattila²,

Schlenzka³

et al. 2000

ATVB

108

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Abstract-A total of 75 in vivo endothelial function tests (intrabrachial artery infusions of endothelium-dependent[acetylcholine] and -independent [sodium nitroprusside] vasoactive agents) were performed in 18 type 2 diabetic patients (aged 58Ϯ2 years, body mass index 28.5Ϯ0.6 kg/m 2 , and fasting plasma glucose 229Ϯ11 mg/dL) and 27 matched normal subjects. These tests were performed before and 6 months after combination therapy with insulin and metformin and before and 6 months after metformin therapy only. Before insulin therapy, blood flow responses to acetylcholine (15 g/min) were significantly blunted in type 2 diabetic patients (7.5Ϯ0.7 mL ⅐ dL Ϫ1 ⅐ min Ϫ1) compared with normal subjects (11.6Ϯ0.9 mL ⅐ dL Ϫ1 ⅐ min Ϫ1 , PϽ0.01). During insulin therapy, the acetylcholine response increased by 44% to 10.8Ϯ1.6 mL ⅐ dL Ϫ1 ⅐ min Ϫ1 (PϽ0.05). Insulin therapy also significantly increased the blood flow responses to both low and high doses of sodium nitroprusside. We conclude that insulin therapy improves endothelium-dependent and -independent vasodilatation. These data support the idea that insulin therapy has beneficial rather than harmful effects on vascular function.

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Section: Vehkavaara Et Al Insulin Therapy and Endothelial Functionsupporting

confidence: 63%

Insulin Therapy Improves Endothelial Function in Type 2 Diabetes

Vehkavaara¹,

Mäkimattila²,

Schlenzka³

et al. 2000

ATVB

108

View full text Add to dashboard Cite

show abstract

“…Type 2 diabetes may cause endothelial dysfunction through hyperglycemia, hyperinsulinemia and lipid disorders (24). Traditional coronary risk factors such as hypertension, hypercholesterolemia, diabetes, increased age, obesity, and cigarette smoking have been shown to contribute to endothelial dysfunction in coronary and peripheral vessels (25,26), but, except for diabetes, these effects were not observed in this study population.…”

Section: Fmd In the Brachial Arteries And Coronary Vasomotor Responsecontrasting

confidence: 47%

Brachial Artery Flow-Mediated Vasodilation Is Correlated with Coronary Vasomotor and Fibrinolytic Responses Induced by Bradykinin

et al. 2005

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“…The relationship between reduced endothelium-dependent vasodilatation and impaired glucose tolerance has been well described [46] and thus our finding of a significant negative correlation between HOMA score and maximum response to acetylcholine is not surprising. Changes in these parameters were not related however, suggesting that FVassociated improvements in endothelium-dependent vasodilatation are not mediated by enhanced insulin sensitivity.…”

Section: Discussionmentioning

confidence: 62%

The effect of increased dietary fruit and vegetable consumption on endothelial activation, inflammation and oxidative stress in hypertensive volunteers

McCall¹,

McGartland²,

McKinley³

et al. 2011

Nutrition, Metabolism and Cardiovascular Diseases

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Impaired endothelium-dependent vasodilation in type 2 diabetes. Relation to LDL size, oxidized LDL, and antioxidants.

Abstract: In summary, patients with type 2 diabetes exhibited impaired endothelium-dependent vasodilation in vivo, elevated serum triglycerides, decreased LDL size, and normal antioxidant capacity. Of these parameters, LDL size was significantly correlated with endothelial function.

Cited by 149 publications

References 8 publications

Insulin Therapy Improves Endothelial Function in Type 2 Diabetes

Insulin Therapy Improves Endothelial Function in Type 2 Diabetes

Brachial Artery Flow-Mediated Vasodilation Is Correlated with Coronary Vasomotor and Fibrinolytic Responses Induced by Bradykinin

The effect of increased dietary fruit and vegetable consumption on endothelial activation, inflammation and oxidative stress in hypertensive volunteers

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