Impaired endothelial function in hypertensive patients with target organ damage

Jz, Xu; Zhang, Y; Sn, Wu; Wq, Niu; Zhu, Dingliang; Gao, Peng

doi:10.1038/jhh.2009.10

Cited by 22 publications

(15 citation statements)

References 23 publications

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“…The results of that study showed that the incidence of cardiovascular events was more than double in those with compromised endothelial function, as defined by the cohort having an FMD value below the median. Furthermore, Xu et al 28 reported that reduced FMD was associated with the extent of multiple target organ damage. Recently, long-term effects of salt sensitivity on cardiovascular disease morbidity and total mortality were determined in a remarkable 27-year follow-up study of 430 normotensives and 278 hypertensives.…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction in normotensive salt-sensitive subjects

et al. 2011

J Hum Hypertens

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Salt-sensitivity is associated with a more severe target organ injury and higher mortality, even in normotensive subjects. As endothelial dysfunction is predictive for future cardiovascular events, we evaluated whether normotensive salt-sensitive (NSS) subjects have more pronounced endothelial dysfunction compared with normotensive salt-resistant (NSR) subjects. Normotensive subjects (n ¼ 99, aged 25-50 years) were selected from a rural community in northern China. Salt sensitivity was assigned if mean BP increased by X10% from a 1-week high salt (18 g/day, NaCl) to low-salt diet (3 g/day, NaCl). Endothelial function was assessed by testing the flow-mediated dilatation (FMD) of the brachial artery using high-resolution ultrasound, as well as nitrogen oxide (NOx) levels, in plasma and urine at baseline. Blood pressure at baseline was similar between NSS and NSR subjects, but diverged during salt intervention. Furthermore, FMD was significantly lower in 17 NSS subjects (10.2 ± 2.5 vs 14.5 ± 1.6%, P ¼ 0.037) compared with NSR subjects. In addition, average plasma NOx levels were lower in NSS subjects than NSR subjects (61.2 ± 3.23 lM vs 82.5 ± 1.61 lM, P ¼ 0.034). Moreover, Both FMD and plasma NOx levels were negatively correlated with the degree of salt sensitivity (r ¼ À0.435 and r ¼ À0.459, respectively, Po0.01). However, there was no difference in urine NOx between the two groups. Our study indicates that endothelial dysfunction could contribute to the long-term higher levels of target organ injury and higher mortality observed in NSS subjects.

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Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction in normotensive salt-sensitive subjects

et al. 2011

J Hum Hypertens

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“…12 We found that reduced FMD was associated with the number of TOD and may be considered an indicator for evaluating TOD. 13 However, little is known about the relationship between LA size, endothelial dysfunction and the number of TOD in hypertensive patients. Therefore, we investigated the correlation between left atrial diameter (LAD), FMD and different markers of TOD in uncomplicated hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

“…Reduced FMD was associated with the number of target organ damage (TOD) and may be considered an indicator for evaluating TOD. 13 What this study adds K Enlargement of left atrial diameter (LAD) may be an important predictor of endothelial dysfunction. K LAD enlargement may be considered to be an indicator for evaluating TOD in hypertensive patients.…”

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confidence: 99%

Left atrial diameter, flow-mediated dilation of brachial artery and target organ damage in Chinese patients with hypertension

et al. 2011

J Hum Hypertens

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To investigate the relationship between left atrial (LA) size, endothelial dysfunction and different markers of target organ damage (TOD), we measured left atrial diameter (LAD) and endothelial function in hypertensive patients with or without TOD. In this study, 197 patients with hypertension were divided into four groups as follows: no TOD (Group I, n ¼ 40), one TOD (Group II, n ¼ 76), two TOD (Group III, n ¼ 46) and X3 TOD (Group IV, n ¼ 35). Endothelial function was assessed by endothelium-dependent vasodilatation (flow-mediated dilation, FMD) of the brachial artery. We also assessed serum creatinine, the urinary albumincreatinine ratio (UACR), the intima-media thickness (IMT) of the common carotid, carotid to femoral pulse wave velocity (cf-PWV) and left ventricular mass index (LVMI). Our results were as follows: LA size was increased in 50.8% of patients and was associated with the number of TOD. LAD was larger in the patient groups with X3 TOD as compared with patients with two TOD, one TOD and no TOD. FMD was lower in patients with LAD enlargement. LAD exhibited significant relationships with serum creatinine, UACR, cf-PWV, IMT and LVMI. In stepwise multivariate regression analysis, LVMI In conclusions, enlargement of LAD may be an important predictor of endothelial dysfunction and may be considered to be an indicator for evaluating TOD in hypertensive patients.

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“…16 A blunted response to forearm or brachial artery endothelium to reactive hyperaemia, commonly assessed by flow-mediated dilation is a recognised predictor of future cardiovascular events in patients with essential hypertension irrespectively of the presence of coronary artery disease. 17,18 Endothelium-dependent vasodilatation is more severely blunted in non-dippers when compared with patients who have dipper hypertension. 19 The presence of more prominent endothelial perturbation in individuals with non-dipping nocturnal BP is also reflected by increased levels of von Willebrand factor, a marker of endothelial damage.…”

Section: Endothelial Dysfunction and Bp Controlmentioning

confidence: 99%

Endothelial dysfunction and diurnal variation of blood pressure: night secrets of arterial hypertension?

Shantsila

2011

J Hum Hypertens

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Impaired endothelial function in hypertensive patients with target organ damage

Cited by 22 publications

References 23 publications

Endothelial dysfunction in normotensive salt-sensitive subjects

Endothelial dysfunction in normotensive salt-sensitive subjects

Left atrial diameter, flow-mediated dilation of brachial artery and target organ damage in Chinese patients with hypertension

Endothelial dysfunction and diurnal variation of blood pressure: night secrets of arterial hypertension?

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