Impaired detrusor contractility: Anything new?

Abstract

Impaired detrusor contractility (IDC) is a poorly defined entity that represents a treatment challenge for the urologist. The etiology of IDC is variable and may include neurologic disorders, inflammatory conditions, and pharmacologic and psychogenic causes. The gold standard for the treatment of IDC is clean intermittent catheterization (CIC). Although well-established as efficacious and safe, CIC may be conceived as a major burden on a patient's quality of life and has been associated with urinary tract infections and urethral and/or bladder injury. Alternative treatment modalities for IDC can be divided into interventions at the nervous system supplying the bladder, the bladder itself, or the bladder outlet. We review and discuss novel and creative treatment options for patients with IDC that have been developed or tested over the past decade.

The effects of the concentration‐dependent erythrocyte distribution of TAK‐802, a potent acetylcholinesterase inhibitor, on rat pharmacokinetics

“…At first, the kinetic parameter values were estimated using the observed C WB and C PL data by Equations (4) and (5). Sequentially, the C WB - (4) and (5).…”

“…At first, the kinetic parameter values were estimated using the observed C WB and C PL data by Equations (4) and (5). Sequentially, the C WB - (4) and (5). In the nonlinear pharmacokinetic model, the K d , B max and N sb were fixed to the values, which were estimated from the results of the i.v.…”

Latissimus Dorsi Detrusor Myoplasty for Neurogenic Underactivity

“…Until now, the only treatment modality had been lifelong clean intermittent catheterization (CIC) with its attendant risks of recurrent urinary tract infection, urethral laceration, and possible deteriorating renal function [3]. In addition, the socioeconomic and psychological burdens of lifelong CIC must be considered [4].…”

Effects of TAK‐802, a novel acetylcholinesterase inhibitor, and tamsulosin, an α1‐adrenoceptor antagonist, and their synergistic effects on the urodynamic characteristics in a guinea‐pig model of functional bladder outlet obstruction

“…Clean intermittent catheterization is the most common therapy for LUTS associated with detrusor under‐activity, but it may cause problems, e.g. UTI and bladder injury [6]. Cholinomimetic drugs, e.g.…”