Impaired coronary microvascular and left ventricular diastolic function in patients with inflammatory bowel disease

Çalışkan, Zuhal; Gokturk, Huseyin Savas; Çalışkan, Mustafa; Güllü, Hakan; Çiftçi, Özgür; Ozgur, Gokhan; Güven, Aytekin; Şelçuk, Haldun

doi:10.1016/j.mvr.2014.08.003

Cited by 33 publications

(27 citation statements)

References 33 publications

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“…This is in accordance with results from two studies of 2015 and 2016, in which the authors have detected impaired coronary microvascular and LV diastolic function in patients with IBD 49, 50 . Similarly to the above outlined rather discrete differences in LV systolic performance indices between IBD patients and healthy volunteers, diastolic dysfunction also only manifests in a subtle manner.…”

Section: Discussionsupporting

confidence: 92%

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Hensel

Schneyder

Wilke

et al. 2017

Sci Rep

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Inflammatory bowel disease (IBD) is an established risk factor for cardiovascular disease (CVD). However, whether cardiac consequences present early in IBD is unknown. This is the first study in children aiming to unmask altered myocardial mechanics in IBD. We enrolled 50 consecutive normotensive children with Crohn’s disease (CD) (n = 28) or ulcerative colitis (UC) (n = 22). The study groups consisted of 18 patients with active inflammatory disease (mean age 14.6 ± 2.5 years) and 32 children with IBD in remission (14.3 ± 2.3 years). 60 age- and gender-matched children served as healthy controls. Speckle tracking stress echocardiography (STE) was used to assess left ventricular (LV) myocardial strain and strain rate. Circumferential strain rate was significantly decreased in children with active IBD (−1.55 ± 0.26 s−1) and IBD in remission (−1.49 ± 0.26 s−1) versus healthy controls (1.8 ± 0.4 s−1) both at rest (p < 0.001) and during exercise (p = 0.021). Moreover, longitudinal strain rate, circumferential strain and E/E′ ratio were significantly impaired in IBD. Pediatric patients with IBD feature subclinical signs of LV systolic and diastolic myocardial impairment early in the course of CD and UC. This may not be reversible even when IBD is clinically controlled. Patients with IBD should be regularly screened for signs of CVD.

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Section: Discussionsupporting

confidence: 92%

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Hensel

Schneyder

Wilke

et al. 2017

Sci Rep

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“…The relationship between ulcerative colitis and cardiovascular diseases is an interesting research area. In the past decade, some studies have been performed in this field, some of which have revealed a correlation between ulcerative colitis and cardiovascular disorders (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Vaghari‐Tabari¹,

Moein²,

Qujeq³

et al. 2017

Ann Colorectal Res

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Background: Ulcerative colitis is a common type of inflammatory bowel disease (IBD). The aim of the present study was to examine the relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients with ulcerative colitis. Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20 were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDA level were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlation coefficient test. P < 0.05 was considered statistically significant. Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitis in comparison with the healthy controls (P < 0.05). No significant correlation was observed between the MDA level and triglyceride, cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed between HDL-C and MDA levels (r, -0.306; P < 0.05). Conclusions:The inverse correlation between HDL-C and MDA levels can be regarded as an indicator of the protective role of HDL-C against lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparison with healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.

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“…Recent prospective trials have shown that the pathogenesis of atherosclerosis is associated with a chronic low-grade inflammation, and an increased hs-CRP level is described as a risk factor for CAD [17, 18]. …”

Section: Discussionmentioning

confidence: 99%

“…Caliskan et al [18] also demonstrated that patients with IBD in remission have increased hs-CRP levels. We also found that hs-CRP levels in patients with IBD in the remission period were significantly higher than those in the normal population, which is consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study [18] identified LV diastolic dysfunction in patients with IBD during the remission period without having a higher burden of conventional atherosclerotic risk factors. We also found that the frequency of left ventricular diastolic dysfunction in patients with IBD is higher than that in the normal population, in agreement with findings of previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Echocardiographic Epicardial Fat Thickness Measurement: A new Screening Test for Subclinic Atherosclerosis in Patients With Inflammatory Bowel Diseases

Özdil

Çalışkan

Keleş

et al. 2017

North Clin Istanbul

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OBJECTIVE:Inflammatory bowel diseases (IBD) consist of a number of chronic inflammatory diseases. Inflammatory process is known to be involved in all stages of atherosclerosis. Early atherosclerosis is reflected by increased levels of carotid artery intima media thickness (c-IMT) and high-sensitivity C-reactive protein (hs-CRP). Epicardial fat thickness (EFT) strongly influences both the formation and progression of atherosclerosis. Recent studies have demonstrated a relationship between c-IMT and hs-CRP levels and the risk of atherosclerosis in patients with IBD. However, no study has yet compared EFT between patients with IBD and the general healthy population. Hence, this study was designed to further evaluate whether patients with IBD have higher EFT values with increased c-IMT and hs-CRP levels compared to those in the healthy population.METHODS:A total of 110 patients with IBD and 105 healthy volunteers were enrolled into this study. EFT was evaluated by transthoracic echocardiography. c-IMT levels were measured using an ultrasound scanner with a linear probe. The plasma levels of hs-CRP were measured using a highly sensitive sandwich ELISA technique.RESULTS:The hs-CRP and c-IMT levels of patients with IBD were significantly higher than those of the control group. The EFT values of patients with IBD were significantly higher than those of the control group (0.54±0.13 vs. 0.49±0.09, p=0.002).CONCLUSION:Echocardiographic EFT measurements of patients with IBD were significantly higher than those of the normal population, which may be associated with an increased subclinical atherosclerosis risk in these patients.

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Impaired coronary microvascular and left ventricular diastolic function in patients with inflammatory bowel disease

Cited by 33 publications

References 33 publications

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Echocardiographic Epicardial Fat Thickness Measurement: A new Screening Test for Subclinic Atherosclerosis in Patients With Inflammatory Bowel Diseases

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