Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Abstract

Background: Ulcerative colitis is a common type of inflammatory bowel disease (IBD). The aim of the present study was to examine the relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients with ulcerative colitis. Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20 were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDA level were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlation coefficient test. P < 0.05 was considered statistically significant. Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitis in comparison with the healthy controls (P < 0.05). No significant correlation was observed between the MDA level and triglyceride, cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed between HDL-C and MDA levels (r, -0.306; P < 0.05). Conclusions:The inverse correlation between HDL-C and MDA levels can be regarded as an indicator of the protective role of HDL-C against lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparison with healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.

Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease

“…Also, MDA level was 126.3% higher in patients compared with the control group. The current results are in agreement with those reporting that MDA level increased in patients with ulcerative colitis (49). A positive correlation between TBARS and disease activity and a negative correlation between FRAP and disease activity expressed the oxidant/antioxidant imbalance and oxidative stress.…”

Exosome-Induced Regulation in Inflammatory Bowel Disease

“…It has previously been demonstrated that cholesterol in the feces of UC patients is increased (68, 70), and that it can inhibit pyroptosis signaling to ameliorate experimental colitis (70). Furthermore, a decrease in high-density lipoprotein-cholesterol in IBD patients has been reported (71).…”

Calprotectin in inflammatory bowel disease

“…IBD arises as a result of inappropriate immune response to intestinal commensal organisms in individuals with genetic predisposition and consequently causes inflammation and intestinal ulcers [1] ,. In addition, IBD has a complex pathogenesis and many factors such as dysbiosis, oxidative stress, and epigenetics that may also be involved in disease pathogenesis [2] , [3] , [4] . Ulcerative colitis (UC) and Crohn's diseases (CD) are known as two main forms of IBD.…”