Impaired Circulation in the Thickened Choroid of a Patient with Serpiginous Choroiditis

Takahashi, Ai; Saito, Wataru; Hashimoto, Yuki; Saito, Michiyuki; Ishida, Susumu

doi:10.3109/09273948.2014.902075

Cited by 17 publications

(10 citation statements)

References 10 publications

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“…These changes in thickness and circulation are therefore called an “inflammatory” pattern in the choroid [19, 20] and also seen in chorioretinal diseases with yet unidentified pathogenesis, such as acute posterior multifocal placoid pigment epitheliopathy or unilateral acute idiopathic maculopathy [21, 22]. Interestingly, this is true with our present (thickness) and previous (circulation) results [8] on AZOOR.…”

Section: Discussionsupporting

confidence: 87%

“…In choroiditis such as Vogt-Koyanagi-Harada disease and serpiginous choroiditis, choroidal thickness decreased and choroidal blood flow velocity increased with regression of these diseases [19, 20], consistent with the inflammatory swelling of the choroid with blood flow disruption at the acute stage. These changes in thickness and circulation are therefore called an “inflammatory” pattern in the choroid [19, 20] and also seen in chorioretinal diseases with yet unidentified pathogenesis, such as acute posterior multifocal placoid pigment epitheliopathy or unilateral acute idiopathic maculopathy [21, 22].…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy

Hashimoto

Saito

et al. 2017

Journal of Ophthalmology

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Purpose To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR). Methods This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced depth imaging optical coherence tomography, choroidal thicknesses at the subfovea and at nasal and temporal sites 1000 μm away from the fovea were manually measured at baseline and 3 and 6 months thereafter. Changes in the choroidal thicknesses and the average threshold at the affected area on Humphrey perimetry were compared during the 6-month follow-up. Results In AZOOR eyes, the average threshold at the affected area significantly increased over time, while outer retinal structure ameliorated. The mean choroidal thicknesses at all the sites measured significantly decreased at 3 and 6 months compared with baseline values in AZOOR eyes, but not in fellow eyes. There was an inverse correlation between the changing rates of the average threshold and the subfoveal choroidal thickness at 6 months from baseline. Conclusion The current data suggest that choroidal thickness at AZOOR-affected area significantly decreased with regression of AZOOR and this anatomical change correlated with the functional recovery.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy

Hashimoto

Saito

et al. 2017

Journal of Ophthalmology

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“…In choroiditis such as Vogt–Koyanagi–Harada disease and serpiginous choroiditis, our previous observations using LSFG and EDI-OCT revealed that macular choroidal blood flow velocity decreased and choroidal thickness increased during the acute stage and systemic corticosteroid therapy reversed these trends [18, 25]. Changes in the blood flow and thickness may be manifestations of a process with an “inflammatory” pattern occurring in the choroid [18, 25].…”

Section: Discussionmentioning

confidence: 99%

“…Changes in the blood flow and thickness may be manifestations of a process with an “inflammatory” pattern occurring in the choroid [18, 25]. Similarly, these changes have been also observed in unilateral acute idiopathic maculopathy [20], acute posterior multifocal placoid pigment epitheliopathy [26], and acute zonal occult outer retinopathy complex [17, 19, 27–30].…”

Section: Discussionmentioning

confidence: 99%

Blood flow velocity and thickness of the choroid in a patient with chorioretinopathy associated with ocular blunt trauma

et al. 2017

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Background: Choroidal circulation hemodynamics in eyes with ocular blunt trauma has not been quantitatively examined yet. We quantitatively examined changes in choroidal blood flow velocity and thickness at the lesion site using laser speckle flowgraphy (LSFG) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with chorioretinopathy associated with ocular blunt trauma. Case presentation: A 13-year-old boy developed a chorioretinal lesion with pigmentation extending from the optic disc to the superotemporal side in the right eye after ocular blunt trauma. The patient's best-corrected visual acuity (BCVA) was 0.2 in the right eye. Indocyanine green angiography showed hypofluorescence from the initial phase, with a decrease of mean blur rate (MBR) on LSFG color map, which corresponded to the chorioretinal lesion. The BCVA and foveal outer retinal morphologic abnormality spontaneously improved during follow-up. MBR and choroidal thickness increased by 23-31% and 13-17 μm at the lesion site and by 11-22% and 33-42 μm at the fovea, respectively, during the 6-month follow-up period after baseline measurements in the affected eye. In contrast, these parameters showed little or no changes at the normal retinal site in the affected eye and the fovea in the fellow eye. Conclusions: Current data revealed that both blood flow velocity and thickness in the choroid at the lesion site decreased in the acute stage and subsequently increased together with improvements in visual function and outer retinal morphology. These results suggest that LSFG and EDI-OCT may be useful indices that can noninvasively evaluate activity of choroidal involvement in ocular blunt trauma-associated chorioretinopathy.

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“…Demonstration of M. tuberculosis DNA by polymerase chain reaction (PCR)-based testing of vitreous fluid from eyes with MSC supports the diagnosis (Figure 2). Two original articles 7,8 and two letters 9,10 in this issue of Ocular Immunology & Inflammation present important findings relevant to the evaluation and management of patients with SC and MSC.…”

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confidence: 99%

The Creeping Choroiditides – Serpiginous and Multifocal Serpiginoid Choroiditis

Cunningham

Zierhut

2014

Ocular Immunology and Inflammation

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Impaired Circulation in the Thickened Choroid of a Patient with Serpiginous Choroiditis

Cited by 17 publications

References 10 publications

Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy

Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy

Blood flow velocity and thickness of the choroid in a patient with chorioretinopathy associated with ocular blunt trauma

The Creeping Choroiditides – Serpiginous and Multifocal Serpiginoid Choroiditis

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