Impaired capacity for autonoetic reliving during autobiographical event recall in mild Alzheimer's disease

Irish, Muireann; Lawlor, Brian A.; O’Mara, Shane M.; Coen, Robert F.

doi:10.1016/j.cortex.2010.01.002

Cited by 132 publications

(122 citation statements)

References 66 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…This finding suggests that even when AD patients have controlled episodic retrieval abilities, the complex retrieval of spontaneous associations may be impaired and successfully retrieved memories may lack contextual details. This assumption is congruent with previous findings that the recall of AD patients is characterised by poor contextual details even when probes are provided to encourage greater recall of details (Irish et al, 2011a(Irish et al, , 2011b.…”

Section: Functional Connectivity During Associative Cersupporting

confidence: 91%

“…Accordingly, as mentioned in the introduction, subjective experience of recollection has frequently been found to be reduced in AD patients (Dalla Barba, 1997;Piolino et al, 2003;Rauchs et al, 2007). Moreover, there is evidence of impoverished vividness and self-referential imagery, constituting impoverished autonoetic consciousness, during the recall of autobiographical memories by AD patients (Irish et al, 2011b). However, other hypotheses concerning the role of the parietal cortex in episodic retrieval might also be compatible with the alteration of functional connectivity between the inferior precuneus/PCC and the inferior parietal cortex during successful CER in AD patients.…”

Section: Functional Connectivity During Associative Cermentioning

confidence: 97%

“…In the same vein, Irish et al have recently examined the quality of the recollective experience for retrograde memories in AD patients (Irish et al, 2011a(Irish et al, , 2011b. They reported that AD patients were impaired across a range of behavioural markers inherent in the recollective experience such as self-referential imagery, vividness and retrieval of contextual details.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Genon

Collette

Feyers

et al. 2013

Cortex

View full text Add to dashboard Cite

Typical Alzheimer's disease (AD) is characterized by an impaired form of associative memory, recollection, that includes the controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be preserved in the early stages of the disease. This is the first study that directly examines whole brain regional activity during one core aspect of the recollection function: associative controlled episodic retrieval (CER), contrasted to item familiarity in AD patients. Cerebral activity related to associative CER and item familiarity in AD patients and healthy controls (HC) was measured with functional magnetic resonance imaging during a word-pair recognition task to which the process dissociation procedure was applied. Some patients had null CER estimates (AD-), whereas others did show some CER abilities (AD+), although significantly less than HC. In contrast, familiarity estimates were equivalent in the three groups. In AD+, as in controls, associative CER activated the inferior precuneus/posterior cingulate cortex (PCC). When performing group comparisons, no region was found to be significantly more activated during CER in HC than AD+ and vice versa. However, during associative CER, functional connectivity between this region and the hippocampus, the inferior parietal and dorsolateral prefrontal cortex (DLPFC) was significantly higher in HC than in AD+. In all three groups, item familiarity was related to activation along the intraparietal sulcus (IPS). In conclusion, whereas the preserved automatic detection of an old item (without retrieval of accurate word association) is related to parietal activation centred on the IPS, the inferior precuneus/PCC supports associative CER ability in AD patients, as in HC. However, AD patients have deficient functional connectivity during associative CER, suggesting that the residual recollection function in these patients might be impoverished by the lack of some recollection-related aspects such as autonoetic quality, episodic details and verification.

show abstract

Section: Functional Connectivity During Associative Cersupporting

confidence: 91%

Section: Functional Connectivity During Associative Cermentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Genon

Collette

Feyers

et al. 2013

Cortex

View full text Add to dashboard Cite

show abstract

“…In particular, the retrieval of self-related information in AD patients lacks contextual details. The results are also congruent with previous studies that have revealed that the retrieval of autobiographical memories in AD patients is deprived of contextual details (Irish, Hornberger, et al, 2011;Irish, Lawlor, et al, 2011;Piolino et al, 2003;Martinelli et al, 2013), suggesting that high-order self-related processes are impaired in AD patients.…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 91%

“…In the same line, the quality of the recollective experience for autobiographical memories is impaired in AD patients (Irish, Hornberger, et al, 2011;Irish, Lawlor, et al, 2011;Piolino et al, 2003). In particular, AD patients are impaired across a range of behavioural characteristics inherent to recollective experience, such as self-referential imagery, vividness and retrieval of contextual details (Irish, Hornberger, et al, 2011;Irish, Lawlor, et al, 2011).…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease

Genon

Bahri

Collette

et al. 2014

Cortex

View full text Add to dashboard Cite

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect (SRRE)). The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer's disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for selfrelevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes-no recognition phases were administrated in an MRI scanner. Brain activation as measured by fMRI was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs. recollective experience).The behavioural results revealed that the SRE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of selfrelated information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgments. However, the variable and limited memory advantage for selfrelated information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgments, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC.

show abstract

Episodic Memory in Neurodegenerative Disorders

Irish¹,

Hornberger²

2015

The Wiley Handbook on the Cognitive Neuroscience of Memory

View full text Add to dashboard Cite

Impaired capacity for autonoetic reliving during autobiographical event recall in mild Alzheimer's disease

Cited by 132 publications

References 66 publications

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease

Episodic Memory in Neurodegenerative Disorders

Contact Info

Product

Resources

About