Impaired Baroreflex Control of Arterial Pressure in WHHL Rabbits.

Katsuda, Shin-ichiro; Hara, Hiroshi; Shiomi, Masashi; Watanabe, Yoshio

doi:10.1292/jvms.54.983

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Zimpfer, et al [24] reported that pentobarbital sodium reduced the capacity to restore hypotension due to hemorrhage. On the other hand, Hosomi and Sagawa [8] and we [13] demonstrated that pentobarbital sodium did not affect the baroreflex AP control capacity after hemorrhage. The reason for the discrepancy in the effect of pentobarbital anesthesia on the control capacity of the baroreflex AP control system, although associated with many factors, remains to be clarified.…”

Section: Introductionmentioning

confidence: 45%

“…On the other hand, rapid mild hemorrhage is the withdrawal of a small amount of blood to allow us to do a precise physiological evaluation of baroreflex function [6,7,[9][10][11]13]. The MAP fall immediately after rapid mild hemorrhage (∆AP I ) is a transient fall in AP due to a small decrease in blood volume in the aorta.…”

Section: Discussionmentioning

confidence: 99%

“…We previously compared the values for CMAP, ∆AP I , ∆AP S and G in the conscious state with those determined 60-90 min after the anesthesia in normal and Watanabe heritable hyperlipidemic (WHHL) rabbits, since the MAP responses were unstable for about 60 min after the onset of the anesthesia [13]. The G value resulted in showing no significant difference between the conscious and anesthetized conditions in either rabbit group.…”

Section: Discussionmentioning

confidence: 99%

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Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits.

et al. 2000

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Abstract:The present study is designed to investigate the time-dependent effect of pentobarbital anesthesia on the baroreflex arterial pressure (AP) control system in rabbits. The overall AP control capacity of the baroreflex system was assessed with mean arterial pressure (MAP) responses to the rapid mild hemorrhage (2 ml/kg body weight) and an overall open-loop gain (G) of the system. The G value was determined by means of the following formula: G=∆AP I /∆AP S -1, where ∆AP I is an immediate MAP fall and ∆AP S a steady-state fall after the rapid hemorrhage. Prior to the experiment, two catheters for AP measurement and hemorrhage were chronically in-dwelt in the aortic arch via the left subclavian and left common carotid arteries, respectively. Control mean arterial pressure averaged for 30 sec before the rapid hemorrhage (CMAP), ∆AP I and ∆AP S significantly increased and reached the maximal value at 14 min (CAMP: p<0.01) and 28 min (∆AP I : p<0.01 and ∆AP S : p<0.01) after the intravenous injection of sodium pentobarbital in a 25.0 mg/kg dose, respectively. These values gradually decreased in the course of time and tended to recover to near the preanesthetic level at 77-98 min after the anesthesia. The G value significantly decreased from 7.3 in the conscious state to 1.5 at 28 min after the anesthesia (p<0.001), gradually increased with lapse of time and recovered to near the preanesthetic level at 77-98 min after the anesthesia. No significant difference in G was observed between in the conscious and anesthetized states beyond 70 min after the anesthesia (p>0.05). These findings suggest that pentobarbital sodium exerts a timedependent inhibitory effect on the baroreflex system but does not significantly affect the overall AP control capacity of the baroreflex system itself at least 70 min after the intravenous administration at a dose of 25.0 mg/kg.

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Section: Introductionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits.

et al. 2000

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Arterial baroreflex dysfunction promotes atherosclerosis in rats

Cai¹,

Xie²,

Lü³

et al. 2005

Atherosclerosis

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Effects of low-dose ketanserin on atherosclerosis in rats and rabbits

Xie

et al. 2010

Can. J. Physiol. Pharmacol.

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The present study was designed to test the hypothesis that a small dose of ketanserin, which enhances baroreflex activity, prevents the early lesions of atherosclerosis. In experiment 1, baroreflex sensitivity (BRS) was measured in 31 spontaneously hypertensive rats (SHRs) in a conscious state using a computerized blood pressure monitoring system. Four weeks later, the rats were administered vitamin D3 and fed a high-cholesterol diet for 8 weeks to induce atherosclerosis. Then their hearts and aortae were removed for pathological examination. A negative correlation was found between BRS and the scores of coronary (r = -0.460, P < 0.01) and aortic atherosclerosis (r = -0.448, P < 0.05) in SHR. In experiment 2, SHRs were divided into 3 groups (n = 10 in each group) and received a dose of ketanserin of 0.3, 1.0, and 3.0 mg/kg (i.g.), respectively. At the smallest dose (0.3 mg/kg), ketanserin did not lower blood pressure but enhanced BRS. In experiment 3, SHRs were administered vitamin D3, fed a high-cholesterol diet, and simultaneously treated with low-dose ketanserin. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (coronary score: 0.90 ± 0.14 vs. 1.76 ± 0.27, P < 0.05; aortic scores: 1.00 ± 0.39 vs. 2.18 ± 0.41, P < 0.05). In experiment 4, male New Zealand White rabbits were fed a high-cholesterol diet and treated with low-dose ketanserin at the same time. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (aortic scores: 0.26 ± 0.20 vs. 0.60 ± 0.31, P < 0.05). In conclusion, the present study demonstrated, for the first time, that low-dose ketanserin prevented the development of atherosclerosis independent of its blood pressure lowering action in SHRs and New Zealand White rabbits at least in part via enhancement of arterial baroreflex function.

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Impaired Baroreflex Control of Arterial Pressure in WHHL Rabbits.

Cited by 4 publications

References 22 publications

Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits.

Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits.

Arterial baroreflex dysfunction promotes atherosclerosis in rats

Effects of low-dose ketanserin on atherosclerosis in rats and rabbits

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