2010
DOI: 10.1139/y10-079
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Effects of low-dose ketanserin on atherosclerosis in rats and rabbits

Abstract: The present study was designed to test the hypothesis that a small dose of ketanserin, which enhances baroreflex activity, prevents the early lesions of atherosclerosis. In experiment 1, baroreflex sensitivity (BRS) was measured in 31 spontaneously hypertensive rats (SHRs) in a conscious state using a computerized blood pressure monitoring system. Four weeks later, the rats were administered vitamin D3 and fed a high-cholesterol diet for 8 weeks to induce atherosclerosis. Then their hearts and aortae were remo… Show more

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Cited by 10 publications
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“…This effect was independent of ABP lowering. 44 Also, in experimental studies on hypertensive rats, the restoration of BRS yielded protection against end-organ damage and against cognitive impairment. 45, 46 Thus, improvement of baroreflex function could be viewed as a potential therapeutic target not only in stroke 47 but also in situations involving risk for cerebrovascular disease.…”
Section: Discussionmentioning
confidence: 99%
“…This effect was independent of ABP lowering. 44 Also, in experimental studies on hypertensive rats, the restoration of BRS yielded protection against end-organ damage and against cognitive impairment. 45, 46 Thus, improvement of baroreflex function could be viewed as a potential therapeutic target not only in stroke 47 but also in situations involving risk for cerebrovascular disease.…”
Section: Discussionmentioning
confidence: 99%