Impaired aerobic capacity in adolescents and young adults after treatment for cancer or non-malignant haematological disease

Aerobic physical capacity and health-related quality of life in children with sickle cell disease

“…49 The group difference in terms of anthropometric parameters may explain the lower magnitude in VO2max difference than in our study, as we used age and gender-matched healthy controls and contemporary pediatric reference Z-score values. 27 Impaired aerobic capacity has been observed in other pediatric chronic diseases concerned with early onset of physical deconditioning and increased cardiovascular risk, but not with this magnitude of VO2max decrease which we observed in sickle cell disease: -6 mL/kg/min in childhood cancer 19 , -4.9 mL/kg/min in childhood asthma 17 , -4.8 mL/kg/min in congenital heart disease 18 . Ultimately, the aerobic capacity impairement in patients with sickle cell disease seems to worsen over time, with a magnitude of the difference with controls of 26.5 mL/kg/min in adult patients.…”

“…58 Psychometric properties showed reliability, validity, and responsiveness to clinical change over time, including for the French version of the PedsQL. 59,60 The self-reported level of physical activity was assessed by the Ricci and Gagnon questionnaire, composed of 9 items, with a total score ranging from 9 to 45 ([9-18] = physical inactivity; [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] = moderate physical activity; [36][37][38][39][40][41][42][43][44][45] = intensive physical activity). 61,62 We also used a sickle cell disease knowledge questionnaire, a non-validated instrument used in patient education in our institution (47 questions, 5 domains, 7 scores, sickle cell knowledge overview score of 70, Appendix 1).…”

“…45 Aerobic fitness assessed by cardiopulmonary exercise test (CPET) best reflects physical capacity in children and adolescents with chronic conditions, providing an analysis of cardiac, respiratory, and peripheral exercise limitations. [17][18][19]50 Indeed, maximum oxygen uptake (VO2max) measured by CPET is a predictor of prognosis and HRQoL in various childhood diseases. [20][21][22][23] Nevertheless, aerobic capacity has been scarcely evaluated in children or adolescents with sickle cell disease, and no CPET study has assessed HRQoL in this population.…”

“…Les enfants et adolescents souffrant de maladie chronique ont souvent une activité physique réduite en raison de limitations objectivées ou ressenties du fait de leur pathologie [17][18][19]. L'inactivité physique entraine un cercle vicieux caractérisé par un déconditionnement à l'effort, une réduction de la capacité fonctionnelle et une altération de la qualité de vie [20]…”

Aerobic physical capacity and health-related quality of life in children with sickle cell disease

“…[10] The group difference in terms of anthropometric parameters may explain the lower magnitude in VO 2max difference than in our study, as we used age and gendermatched healthy controls and contemporary pediatric reference Z-score values. [30] Impaired aerobic capacity has been observed in other pediatric chronic diseases concerned with early onset of physical deconditioning and increased cardiovascular risk, but not with this magnitude of VO 2max decrease which we observed in sickle cell disease: -6 mL/kg/min in childhood cancer [23], -4.9 mL/kg/min in childhood asthma [22], -4.8 mL/kg/min in congenital heart disease [21]. Ultimately, the aerobic capacity impairement in patients with sickle cell disease seems to worsen over time, with a magnitude of the difference with controls of 26.5 mL/kg/min in adult patients.…”