Impacts of single nucleotide polymorphisms in three microRNAs (miR-146a, miR-196a2 and miR-499) on the susceptibility to cervical cancer among Indian women

Thakur, Nisha; Singhal, Piyush; Mehrotra, Ravi; Bharadwaj, Mausumi

doi:10.1042/bsr20180723

Cited by 22 publications

(29 citation statements)

References 54 publications

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“…Furthermore, the C allele of rs11614913 might be a risk factor for CIN and cervical cancer. Our result was consistent with the Thakur et al results [42]. In 2016, Torruella-Loran et al found that rs11614913 in miR-196a2 has a function in regulating the expression of several genes involved in cancer [43].…”

Section: Discussionsupporting

confidence: 93%

Polymorphisms in miRNA genes play roles in the initiation and development of cervical cancer

Zhang¹,

Zhou²,

Li³

et al. 2019

J. Cancer

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MicroRNA deregulation is crucial for cancer development. Studies showed that polymorphisms in miRNA genes could affect miRNA expression, which might be associated with cancer development. In the current study, we investigated the association of seven single nucleotide polymorphisms (SNPs) in seven miRNA genes with the initiation and development of cervical cancer in a Chinese Han population. The SNPs of 358 cervical intraepithelial neoplasia (CIN) patients, 547 cervical cancer patients and 567 healthy individuals were genotyped using TaqMan assays. Moreover, we evaluated the association of the seven SNPs with the different stages of cervical cancer. Our results showed that rs4636297 in miR-126 was associated with susceptibility to CIN and cervical cancer (P=0.019 and 0.019, respectively) and that the T allele was associated with a higher risk of CIN (OR=1.334, 95% CI: 1.049-1.698) and cervical cancer (OR=1.296, 95% CI: 1.044-1.609). Similarly, rs11614913 in miR-125a was associated with CIN and cervical cancer (P=0.025 and 0.015, respectively), and the T allele might be the protective factor for CIN (OR=0.807, 95% CI: 0.669-0.974) and cervical cancer (OR=0.814, 95% CI: 0.689-0.961). Our results indicated that rs4636297 in miR-126 and rs11614913 in miR-196a2 play an important role only in the initiation of cervical cancer not in the development of CIN to cervical cancer.

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Section: Discussionsupporting

confidence: 93%

Polymorphisms in miRNA genes play roles in the initiation and development of cervical cancer

Zhang¹,

Zhou²,

Li³

et al. 2019

J. Cancer

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“…Among these, there were studies that were carried out among Asians ( n : 20), Caucasians ( n : 5), Africans ( n : 1), or South Americans ( n : 1). The genotype counts among the control group of six studies deviated from Hardy-Weinberg Equilibrium (HWE) expectations [36,46,52,70,78,92]. The meta-analysis by pooling ORGs found no significant association between rs2910164 and female neoplasms (Table 2 and Figure 2: top-left panel, ORG (95%CI): 0.94 (0.84–1.05), P : 0.29).…”

Section: Resultsmentioning

confidence: 98%

“…Twenty-eight association studies with a total of 11,071 cases and 12,312 controls were included in the meta-analysis of miR-146a rs2910164 and the risk of female neoplasms (Table 1 and Figure 2) [26,28,32,33,34,35,36,38,42,46,47,50,52,55,60,63,67,68,69,70,73,74,77,78,80,81,83,92]. Among these, there were studies that were carried out among Asians ( n : 20), Caucasians ( n : 5), Africans ( n : 1), or South Americans ( n : 1).…”

Section: Resultsmentioning

confidence: 99%

Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms

Bastami

Choupani

Saadatian

et al. 2019

IJMS

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Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsistent findings in the literature should be detected and resolved to facilitate the genetic screening of miRNA polymorphisms, even during childhood or adolescence, and their use as predictors of future malignancies. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and the risk of female neoplasms. Meta-analysis was performed by pooling odds-ratios (ORs) and generalized ORs while using a random-effects model for 15 miRNA polymorphisms. The results suggest that miR-146a rs2910164 is implicated in the susceptibility to GCa. Moreover, miR-196a2 rs11614913-T had a moderate protective effect against female neoplasms, especially GCa, in Asians but not in Caucasians. MiR-27a rs895819-G might pose a protective effect against BCa among Caucasians. MiR-499 rs3746444-C may slightly increase the risk of female neoplasms, especially BCa. MiR-124 rs531564-G may be associated with a lower risk of female neoplasms. The current evidences do not support the association of the remaining polymorphisms and the risk of female neoplasms.

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“…Polymorphisms within miRNAs sequences affecting miRNA expression and/or miRNA-target pair sites [ 44 ]. Genetic polymorphisms in miRNAs have been shown to be involved in the initiation and progression of several cancers [ 5 , 35 , 45 , 46 ]. It has been proposed that miR-3131 may act as a protooncogene in HCC [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer

Azizi

Rahimi

Bahari

et al. 2020

MIRNA

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Aims: This study aimed at examining the effect of 3-bp pre-miR-3131 insertion/deletion (ins/del) polymorphism on Breast Cancer (BC) risk. Objectives: Totally 403 women including 199 BC patients and 204 women who have no cancer were included in this case-control study. Genotyping of miR-3131 3-bp ins/del polymorphism was performed by mismatch PCR-RFLP method. Methods: The findings expressed that the pre-miR-3131 3-bp ins/del variant was not related to the risk of BC in all genetic tested models. While, the ins/del genotype was related to late onset BC (OR=2.53, 95%CI=1.27-4.84, p=0.008). Results: Pooled results from the meta-analysis indicated to that the pre-miR-3131 ins/del is related to with an increased risk of cancer in heterozygous (OR=1.26, 95%CI=1.06-1.51, p=0.01), dominant (OR=1.33, 95%CI=1.14-1.54, p=0.0002), and allele (OR=1.24, 95%CI=1.06-1.45, p=0.006) genetics models. Conclusion: It is concluded that, our findings did not support a relationship between pre-miR-3131 ins/del polymorphism and the risk of BC. While, this variant was significantly related to late onset BC. Combined results of this study with previous studies indicated that this polymorphism increased the risk of cancer. More studies in a study with larger population with variety of ethnicities are required to verify our findings.

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Impacts of single nucleotide polymorphisms in three microRNAs (miR-146a, miR-196a2 and miR-499) on the susceptibility to cervical cancer among Indian women

Cited by 22 publications

References 54 publications

Polymorphisms in miRNA genes play roles in the initiation and development of cervical cancer

Polymorphisms in miRNA genes play roles in the initiation and development of cervical cancer

Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms

The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer

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