Impacts of HIV-1 Subtype Diversity on Long-Term Clinical Outcomes in Antiretroviral Therapy in Guangxi, China

Jiang, He; Lan, Guanghua; Zhu, Qingqing; Feng, Yi; Liang, Shujia; Li, Jianjun; Zhou, Xinjuan; Lin, Min; Shao, Yiming

doi:10.1097/qai.0000000000002906

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…This study found that PLWH infected with CRF01_AE had worse CD4(+) T cell count recovery than that infected with CRF07_BC, which was mainly due to the higher percentage of X4 gonotropic virus. 6 , 7 In addition, the CD4(+) T cell count recovery rate of PLWH infected with CRF85_BC was lower than that of PLWH infected with CRF07_BC. As the subtype of the virus is currently mainly prevalent among the heterosexually transmitted elderly people in southern Sichuan, 7 it is once again emphasized that the virus is needed to pay close attention of the health department.…”

Section: Discussionmentioning

confidence: 98%

“…6 , 7 In addition, the CD4(+) T cell count recovery rate of PLWH infected with CRF85_BC was lower than that of PLWH infected with CRF07_BC. As the subtype of the virus is currently mainly prevalent among the heterosexually transmitted elderly people in southern Sichuan, 7 it is once again emphasized that the virus is needed to pay close attention of the health department. It is necessary to strengthen the prevention and control of AIDS among people infected with the virus, reduce the spread of the virus, and formulate effective measures to strengthen the treatment quality of PLWH.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, CD4(+) T cells recovery in PLWH infected with CRF07_BC, CRF08_BC and CRF01_AE strains was found to have different characteristics during treatment. 6 , 7 In addition to the prevalence of the above subtypes of HIV in Sichuan Province, a new subtype of HIV, named CRF85_BC 8 , has been found in the south of Sichuan Province in recent years. The purpose of this study was to investigate the immune progression and immune recovery of PLWH associated with different subtypes of virus.…”

Section: Introductionmentioning

confidence: 99%

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CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study

Yuan¹,

Zhang²,

Li³

et al. 2022

IDR

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Background Choosing patients with HIV/AIDS (PLWH) with virologic failure observed in the course of treatment, and analyzing the CD4(+) T cell count of PLWH with different subtypes of virus and the risk factors of CD4 (+) T cell count recovery Methods Analyze and evaluate the change of median CD4(+) T cell count of PLWH infected with different HIV-1 subtypes in Sichuan Province after treatment by rank sum test. Univariate and multivariate logistic regression models were used to analyze the risk factors on CD4(+) T cell count growth after PLWH treatment. Results A total of 4977 cases were analysed, including CRF07_BC 2358 cases (47.38%), CRF01_AE 1507 cases (30.28%), CRF08_BC 577 cases (11.59%), CRF85_BC 303 cases (6.09%) and other subtypes 232 cases (4.66%). PLWH infected with CRF85_BC had lower median CD4(+) T cell count after treatment (p < 0.05). It was found that protective factors to increase CD4(+) T cell count (p < 0.05) including females, Yi people, married or cohabiting, educational level at primary school or above, initial and recent treatment with Tenofovir + Lamivudine + Nevirapine Wellen, the second-line regimen with lopinavir/ritonavir (LPV/r) and the treatment time is more than 24 months. However, over 50 years old, the disease course is in AIDS stage, the infection of CRF01_AE and CRF85_BC virus was the risk factor on CD4(+) T cell count increase (p < 0.05). PLWH with higher initial CD4 level had a lower ratio of CD4(+) T cell count increase (≥50 cells/μL) (p < 0.05). Conclusion Age, sex, ethnicity, marriage, education, disease status, treatment protocols, treatment time, initial CD4(+) T cell count, and virus subtype are the influencing factors of PLWH CD4(+) T cell count increase. The poor recovery of CD4(+) T cell count after treatment was observed in PLWH infected with CRF85_BC virus.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study

Yuan¹,

Zhang²,

Li³

et al. 2022

IDR

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“…The risk of transmission of newly reported HIV infections infected of the subtype CRF01_AE in this area is higher than that of newly reported HIV infections of the subtype CRF07_BC, while the CD4(+) T-cell recovery of newly reported HIV infections of the subtype CRF01_AE is worse than that of subtype CRF07_BC infections. The main reason for this is the higher proportion of X4 tropic viruses [30,31], which will bring great challenges for the follow-up treatment of newly reported HIV infections of the subtype CRF01_AE. Therefore, the monitoring of subtype CRF01_AE transmission in this area should be strengthened to reduce the prevalence of this subtype in this area.…”

Section: Discussionmentioning

confidence: 99%

Molecular Transmission Network of Newly Reported HIV Infections in Pengzhou, Sichuan Province: A Study Based on Genomics and Spatial Epidemiology

Yuan

Zhong

et al. 2023

IJERPH

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Objective: The objective of this study was to understand the molecular transmission characteristics of newly reported HIV infections in the city of Pengzhou, Sichuan Province, to analyze the risk factors of transmission network and spatial clustering and the transmission characteristics, and to provide a scientific basis for precision prevention and intervention. Methods: Anticoagulated whole blood was collected from newly reported HIV infections in Pengzhou from March 2019 to August 2021. After the plasma was isolated, the HIV-1 pol gene was amplified and sequenced by reverse transcriptase polymerase chain reaction (PCR). The obtained gene sequences were used to construct a maximum likelihood phylogenetic tree for the analysis of virus subtypes, and a molecular transmission network was constructed using the genetic distance method to evaluate the transmission pattern of people living with HIV/AIDS in Pengzhou. A logistic regression model was used to find out the potential risk factors for entering the molecular transmission network with the number of nodes ≥ 2. Spatial analysis is used to show the geographical pattern of the proportion of newly reported HIV infections entering the molecular transmission network, and a flow map is used to show the intensity of transmission within and between townships. Results: A total of 463 newly reported HIV-infection sequences were obtained in this study, including 237 cases (51.19%) of CRF01_ AE, 159 cases (34.34%) of CRF07_BC, 45 cases (9.72%) of B, 15 cases (3.24%) of CRF08_BC and 7 cases (1.5%) of others. The number of clusters was the highest when the gene distance was 0.009, with a total of 246 sequences entering the network, forming 54 clusters, and the network entry rate was 55.36%. There were 170 sequences with more than two nodes in the network sequence. The logistic regression showed that compared with age < 50 years old, age ≥ 50 years old has a higher risk of transmission (OR = 3.43, 95% CI = 2.06–5.71); compared with farmers, the risk of transmission within industry is lower (OR = 0.046, 95% CI = 0.25–0.87); and compared with CRF07_BC, CRF01_AE (OR = 6.09, 95% CI = 3.60–10.30) and B (OR = 20.31, 95% CI = 8.94–46.13) had a higher risk of transmission. Men aged ≥ 50 years are mainly clustered with women between 50 and 70 years of age. In addition to being clustered with gay men, there are nine (50%) and three (16.7%) chains of transmission between gay men and heterosexual men and women, respectively. In the geographical space, there is no hot spot clustering of the molecular propagation network. The subtype B was mainly distributed in the town of Tianpeng and formed transmission networks in eastern Pengzhou;0020CRF01_AE is mainly distributed in the town of Lichun and formed transmission networks in the west and north of Pengzhou. Conclusion: This study reveals the characteristics and influencing factors of molecular network transmission in the region, as well as the spatial transmission characteristics of newly reported HIV infections in recent years, and reveals the geographical differences in HIV-1 transmission. The results provide a scientific basis for the development of local AIDS-specific intervention measures.

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“…An analysis of the impact of HIV-1 subtype diversity on long-term clinical outcomes of ART in Guangxi Province suggested that patients with CRF01_AE may benefit more from immediate ART than those with CRF07_BC. 19 However, studies in southern Nigeria and the UK did not report an association between HIV-1 subtypes and immunological or virological responses after treatment. 20 21 Therefore, we hypothesised that the effectiveness of ART differs among HIV-1 subtypes.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the immunological response to antiviral therapy in patients with different subtypes of HIV/AIDS: a retrospective cohort study

Liu,

Wang,

Yang

et al. 2024

BMJ Open

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ObjectiveTo evaluate the effectiveness of standardised antiretroviral therapy (ART) among different HIV subtypes in people living with HIV/AIDS (PLWHA), and to screen the best ART regimen for this patient population.DesignA retrospective cohort study was performed, and PLWHA residing in Huzhou, China, between 2018 and 2020, were enrolled.Setting and participantsData from 625 patients, who were newly diagnosed with HIV/AIDS in the AIDS Prevention and Control Information System in Huzhou between 2018 and 2020, were reviewed.Analysis and outcome measuresData regarding demographic characteristics and laboratory investigation results were collected. Immune system recovery was used to assess the effectiveness of ART, and an increased percentage of CD4+T lymphocyte counts >30% after receiving ART for >1 year was determined as immunopositive. A multiple logistic regression model was used to comprehensively quantify the association between PLWHA immunological response status and virus subtype. In addition, the joint association between different subtypes and treatment regimens on immunological response status was investigated.ResultsAmong 326 enrolled PLWHA with circulating recombinant forms (CRFs) CRF01_AE, CRF07_BC and other HIV/AIDS subtypes, the percentages of immunopositivity were 74.0%, 65.6% and 69.6%, respectively. According to multivariate logistic regression models, there was no difference in the immunological response between patients with CRF01_AE, CRF07_BC and other subtypes of HIV/AIDS who underwent ART (CRF07_BC: adjusted OR (aOR) (95% CI) = 0.8 (0.4 to 1.4); other subtypes: aOR (95% CI) = 1.2 (0.6 to 2.3)). There was no evidence of an obvious joint association between HIV subtypes and ART regimens on immunological response.ConclusionsStandardised ART was beneficial to all PLWHA, regardless of HIV subtypes, although it was more effective, to some extent, in PLWHA with CRF01_AE.

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Impacts of HIV-1 Subtype Diversity on Long-Term Clinical Outcomes in Antiretroviral Therapy in Guangxi, China

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 6 publications

References 45 publications

CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study

CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study

Molecular Transmission Network of Newly Reported HIV Infections in Pengzhou, Sichuan Province: A Study Based on Genomics and Spatial Epidemiology

Analysis of the immunological response to antiviral therapy in patients with different subtypes of HIV/AIDS: a retrospective cohort study

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