Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine

Kletečka-Pulker, Maria; Mondal, Himel; Wang, Dongdong; Parra, R. Gonzalo; Maigoro, Abdulkadir Yusif; Lee, Soojin; Garg, Tushar; Mulholland, Eoghan J.; Devkota, Hari Prasad; Konwar, Bikramjit; Patnaik, Sourav S.; Lordan, Ronan; Nawaz, Faisal A.; Tsagkaris, Christos; Rayan, Rehab Α.; Louka, Anna Maria; De, Ronita; Badhe, Pravin; Schaden, Eva; Willschke, Harald; Maleczek, Mathias; Boyina, Hemanth Kumar; Khalid, Garba M.; Sanusi, .; Khan, Johra; Odimegwu, Joy Ifunanya; Yeung, Andy Wai Kan; Akram, Faizan; Sai, Chandragiri Siva; Bucher, Sherri; Paswan, Shravan Kumar; Singla, Rajeev K.; Shen, Bairong; Lonardo, Sara Di; Tosevska, Anela; Simal‐Gándara, Jesús; Zec, Manja; González-Burgos, Elena; Habijan, Marija; Battino, Maurizio; Giampieri, Francesca; Tikhonov, Aleksei; Cianciosi, Danila; Quiles, José L.; Mezzetti, Bruno; Babiaka, Smith B.; Ahmed, Mohammed E; Piccard, Paula; Urquiza, Mágali S.; Depew, Jennifer R.; Schultz, Fabien; Sur, Daniel; Pai, Sandeep R.; Găman, Mihnea‐Alexandru; Cenanovic, Merisa; Tzvetkov, Nikolay; Tripathi, Surya Kant; Kharat, Kiran; García-Sosa, Alfonso T.; Sieber, Simon; Atanasov, Atanas G.

doi:10.1016/j.crbiot.2021.04.004

Cited by 15 publications

(12 citation statements)

References 32 publications

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“…Simultaneously, established phytocompounds based anticancer drugs such as cabazitaxel (Jevtana R ) can benefit from nanoparticle drug design in future clinical studies. Digital health applications can improve retrospective and prospective research to assess natural compound-based nanoparticles more comprehensively (Kletecka-Pulker et al, 2021). Research in the field can also be enriched by the compassionate administration of such nanomedicines in patients with advanced disease under designated regulatory frameworks.…”

Section: Discussionmentioning

confidence: 99%

Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies

Singla

Sai

Chopra

et al. 2021

Front. Cell Dev. Biol.

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Prostate cancer is the most common type of cancer among men and the second most frequent cause of cancer-related mortality around the world. The progression of advanced prostate cancer to castration-resistant prostate cancer (CRPC) plays a major role in disease-associated morbidity and mortality, posing a significant therapeutic challenge. Resistance has been associated with the activation of androgen receptors via several mechanisms, including alternative dehydroepiandrosterone biosynthetic pathways, other androgen receptor activator molecules, oncogenes, and carcinogenic signaling pathways. Tumor microenvironment plays a critical role not only in the cancer progression but also in the drug resistance. Numerous natural products have shown major potential against particular or multiple resistance pathways as shown by in vitro and in vivo studies. However, their efficacy in clinical trials has been undermined by their unfavorable pharmacological properties (hydrophobic molecules, instability, low pharmacokinetic profile, poor water solubility, and high excretion rate). Nanoparticle formulations can provide a way out of the stalemate, employing targeted drug delivery, improved pharmacokinetic drug profile, and transportation of diagnostic and therapeutic agents via otherwise impermeable biological barriers. This review compiles the available evidence regarding the use of natural products for the management of CRPC with a focus on nanoparticle formulations. PubMed and Google Scholar search engines were used for preclinical studies, while ClinicalTrials.gov and PubMed were searched for clinical studies. The results of our study suggest the efficacy of natural compounds such as curcumin, resveratrol, apigenin, quercetin, fisetin, luteolin, kaempferol, genistein, berberine, ursolic acid, eugenol, gingerol, and ellagic acid against several mechanisms leading to castration resistance in preclinical studies, but fail to set the disease under control in clinical studies. Nanoparticle formulations of curcumin and quercetin seem to increase their potential in clinical settings. Using nanoparticles based on betulinic acid, capsaicin, sintokamide A, niphatenones A and B, as well as atraric acid seems promising but needs to be verified with preclinical and clinical studies.

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Section: Discussionmentioning

confidence: 99%

Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies

Singla

Sai

Chopra

et al. 2021

Front. Cell Dev. Biol.

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“…There were five questions with variable response options. We posted the poll with relevant hashtags with #INPST and #DHPSP (Digital Health and Patient Safety Platform) as the common hashtags [ 14 ]. These questions were reviewed by an expert panel of three persons for content validity.…”

Section: Methodsmentioning

confidence: 99%

Twitter Poll as a Medium for Questionnaire-Based Health Survey: An Experience of a Pilot Study on the Preference of Systems of Medicine for Various Health Conditions

Mondal¹,

Modak²,

Selim³

et al. 2022

Cureus

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BackgroundThe easy accessibility of smartphones and internet connections enables people to stay virtually connected to communities via social media. However, social media is also being explored for health care education and dissemination of health-related information. Twitter (Twitter, Inc., San Francisco, California) is one of the popular social media used for spreading health-related information. Twitter enables users to create polls to get opinions from their users. The Twitter poll is a less-explored avenue for health surveys. ObjectiveIn this pilot study, we aimed to explore the feasibility of conducting a questionnaire-based health survey (on the preference of different systems of medicine for the treatment of various health problems) as a Twitter poll. MethodsThis observational study was conducted on Twitter for five consecutive days starting from May 31, 2021. We posted five Twitter polls, one poll each day, for five days in a #INPST unique Twitter campaign. Preferences on the use of modern medicine, traditional medicine, a combination of these two systems, and selfmedication were collected on five health conditions. We collected the data from the landing poll page and Tweet Analytics (insight about the engagement of tweets provided free by Twitter). The Chi-square test, binomial test, and one-way Analysis of Variance were used to compare data, and Spearman's rank correlation coefficient was used to find a correlation between categorical variables. ResultsWe had a mean 4358.6±590.3 poll reach with the engagement of 108.2±36.87 Twitter users and 67.6±28.06 votes. Most of the responses were received on the first day of posting the poll. The participation then gradually decreased. Modern medicine was the first choice for emergency medical care (85.1%, P <0.0001), treatment of cancer (43.6%, P <0.0001), and sexual disorder or transmitted diseases (48.9%, P <0.0001). Traditional medicine was the first choice (37.5%, P = 0.63) for the treatment of common illnesses, and a combination of modern and traditional medicine was the first choice (37.5%, P = 0.01) for the treatment of chronic diseases.

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“…In Europe [51], China [52], and India [53], similar trends were observed. The potential use of nutraceuticals and supplements during the pandemic was a topic of enthusiastic debate on social media [54] and in the literature [13,55,56]. In this context, intense debate on the efficacy and safety of nutraceuticals for the prevention and/or treatment of COVID-19 is ongoing, and sales of nutraceuticals are expected to remain high in the first half of 2021, albeit at much lower level than the sales achieved at the beginning of the pandemic [57].…”

Section: The Impact Of the Covid-19 Pandemic On The Global Nutraceuti...mentioning

confidence: 99%

The current use and evolving landscape of nutraceuticals

Chopra¹,

Lordan²,

Horbańczuk

et al. 2022

Pharmacological Research

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Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine

Cited by 15 publications

References 32 publications

Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies

Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies

Twitter Poll as a Medium for Questionnaire-Based Health Survey: An Experience of a Pilot Study on the Preference of Systems of Medicine for Various Health Conditions

The current use and evolving landscape of nutraceuticals

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