Impact on fatigue of different types of physical exercise during adjuvant chemotherapy and radiotherapy in breast cancer: systematic review and meta-analysis

Torres, Daniele Medeiros; Koifman, Rosalina Jorge; Santos, Sabrina da Silva

doi:10.1007/s00520-022-06809-w

Cited by 26 publications

(19 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the study size and consequently statistical power were limited, we may have overlooked additional correlations that a larger study could have revealed. Longitudinal data from various timepoints during radiotherapy may provide additional information when trying to provide comprehensive, individualized supportive measures such as physical exercise, physiotherapy, psycho-oncology referral, rehabilitation, and others [ 19 , 20 ], aiming at high rates of treatment completion, better QoL and role-functioning, and minimum interference of breast cancer treatment with survivors’ daily life.…”

Section: Discussionmentioning

confidence: 99%

Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden

Nieder,

Johnsen,

Winther

et al. 2024

Strahlenther Onkol

View full text Add to dashboard Cite

Background Multimodal breast cancer treatment may cause side effects reflected in patient-reported outcomes and/or symptom scores at the time of treatment planning for adjuvant radiotherapy. In our department, all patients have been assessed with the Edmonton Symptom Assessment System (ESAS; a questionnaire addressing 11 major symptoms and wellbeing on a numeric scale of 0–10) at the time of treatment planning since 2016. In this study, we analyzed ESAS symptom severity before locoregional radiotherapy. Patients and methods Retrospective review of 132 patients treated between 2016 and 2021 (all comers in breast-conserving or post-mastectomy settings, different radiotherapy fractionations) was performed. All ESAS items and the ESAS point sum were analyzed to identify subgroups with higher symptom burden and thus need for additional care measures. Results The biggest patient-reported issues were fatigue, pain, and sleep problems. Patients with triple negative breast cancer reported a higher symptom burden (mean 30 versus 20, p = 0.038). Patients assigned to adjuvant endocrine therapy had the lowest point sum (mean 18), followed by those on Her-2-targeting agents without chemotherapy (mean 19), those on chemotherapy with or without other drugs (mean 26), and those without systemic therapy (mean 41), p = 0.007. Those with pathologic complete response after neoadjuvant treatment had significantly lower anxiety scores (mean 0.7 versus 1.8, p = 0.03) and a trend towards lower depression scores, p = 0.09. Conclusion Different surgical strategies, age, and body mass index did not impact on ESAS scores, while the type of adjuvant systemic therapy did. The effect of previous neoadjuvant treatment and unfavorable tumor biology (triple negative) emerged as important factors associated with symptom burden, albeit in different domains. ESAS data may facilitate identification of patients who should be considered for additional supportive measures to alleviate specific symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden

Nieder,

Johnsen,

Winther

et al. 2024

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

“…Nowadays, physiotherapy interventions such as physical exercise and respiratory physiotherapy are performed not only after the oncological treatment, but also as a preparation for the surgery [ 9 ], or even during adjuvant chemoradiotherapy [ 10 ]. These interventions have been shown to reduce the negative impact produced by oncological treatment, in both living with and beyond cancer [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Physiotherapy Interventions in Lung Cancer Patients: A Systematic Review

Valdivia-Martínez,

Fernández-Gualda,

Gallegos-García

et al. 2024

Cancers

View full text Add to dashboard Cite

Background: Lung cancer is a very common disease and leads to a series of sequelae such as reduced lung capacity or reduced functional capacity in patients, which are associated not only with the disease itself, but also with medical treatment. Thus, physiotherapeutic interventions are needed to improve quality of life and reduce these symptoms. Objectives: To find out the effects of physiotherapy on functional capacity, lung capacity, dyspnea, pain, and quality of life in lung cancer patients. Methods: A systematic review was carried out in five databases. Randomized clinical trials published between 2019–2023 were selected, in which the physiotherapeutic treatment was physical exercise and/or respiratory physiotherapy. Results: Nine articles were included, in which the total sample consisted of 635 lung cancer patients. When combined, respiratory physiotherapy and physical exercise improved functional capacity and lung capacity (p < 0.05). Dyspnea also improved, but less significance was shown in the included studies. Conclusions: Multimodal physiotherapy interventions may offer benefits for some lung cancer patients, but the extent and nature of these benefits may vary depending on the intervention applied. Therefore, it would be of great interest to carry out further scientific research to support this conclusion.

show abstract

“…Based on the current level of favourable clinical outcomes, physical activity (PA) has been considered to be one of the most beneficial interventions in preventing or relieving fatigue and has been recommended in the clinical guidelines (Okely et al, 2021 ; Thong et al, 2020 ). Several systematic reviews and meta‐analyses concluded the effects of PA intervention on CRF (Andersen et al, 2022 ; Liu et al, 2021 ; Medeiros Torres et al, 2022 ; Toohey et al, 2022 ; Van Vulpen et al, 2020 ), and most of these studies showed positive outcomes (Liu et al, 2021 ; Medeiros Torres et al, 2022 ; Toohey et al, 2022 ; Van Vulpen et al, 2020 ). However, there is significant heterogeneity due to these studies mainly focusing on survivors diagnosed with breast cancer or prostate cancer (Andersen et al, 2022 ; Liu et al, 2021 ; Medeiros Torres et al, 2022 ; Toohey et al, 2022 ; Van Vulpen et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Several systematic reviews and meta‐analyses concluded the effects of PA intervention on CRF (Andersen et al, 2022 ; Liu et al, 2021 ; Medeiros Torres et al, 2022 ; Toohey et al, 2022 ; Van Vulpen et al, 2020 ), and most of these studies showed positive outcomes (Liu et al, 2021 ; Medeiros Torres et al, 2022 ; Toohey et al, 2022 ; Van Vulpen et al, 2020 ). However, there is significant heterogeneity due to these studies mainly focusing on survivors diagnosed with breast cancer or prostate cancer (Andersen et al, 2022 ; Liu et al, 2021 ; Medeiros Torres et al, 2022 ; Toohey et al, 2022 ; Van Vulpen et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The content and effectiveness of physical activity for cancer‐related fatigue among colorectal cancer survivors: Systematic review and meta‐analysis

Geng

Guo

et al. 2023

Nursing Open

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the third most frequent cancer globally; according to the latest data, the incidence of new colorectal cancer cases was as high as 10%, and the number of new cases worldwide reached 1.93 million in 2020 (Sung et al., 2021). One of the most common treatment options for CRC in clinical practice is radical resection combined with chemotherapy, which has greatly improved the survival rate (Iveson et al., 2019). However, the quality of life of CRC patients has not been promoted significantly due to the many adverse effects caused by cancer itself and treatments, especially chemotherapy, such as chronic pain, sleep disturbances, fatigue, depression and so on (Ketelaers et al., 2022;Sakr et al., 2020).Therefore, the burden of follow-up care for CRC survivors is expected to increase, and exploring ways to improve cancer-related symptoms and quality of life in this population deserves attention.Cancer-related fatigue (CRF), a sustained and distressing sense of tiredness or exhaustion, is currently recognized as one of the

show abstract

Impact on fatigue of different types of physical exercise during adjuvant chemotherapy and radiotherapy in breast cancer: systematic review and meta-analysis

Cited by 26 publications

References 59 publications

Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden

Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden

Physiotherapy Interventions in Lung Cancer Patients: A Systematic Review

The content and effectiveness of physical activity for cancer‐related fatigue among colorectal cancer survivors: Systematic review and meta‐analysis

Contact Info

Product

Resources

About