Impact on daily functioning and indirect/direct costs associated with chemotherapy-induced nausea and vomiting (CINV) in a US population

Abstract

CINV remains a significant problem among US patients, suggesting a need for more effective prophylaxis use in clinical practice.

Effectiveness of antiemetics in control of antineoplastic chemotherapy-induced emesis at home

“…A study of 178 American patients also showed the high occurrence of emesis, since in their results, 34% and 58% of participants experienced acute and delayed nausea and vomiting, respectively. (11) It has been discussed and accepted that the emetogenic profile of chemotherapy drugs is primarily responsible for the intensity and duration of emesis. (8) Among the 42 studied patients, all have experienced emetic episodes, revealing that despite one of the schemes being composed by fluorouracil, the addition of this chemotherapy drug did not alter the emetogenic profile of the protocol (data not shown).…”

“…However, some studies support the idea that due to irregular use of prescribed medication, some patients may not be benefiting from the treatment of prophylaxis. (11) Women taking the prescribed antiemetics irregularly argued that followed this routine for not having the habit of using any medication on a regular basis, for considering it unnecessary in face of the discomfort caused by emesis, and due to side effects of antiemetics.…”

“…(7) In another study, the authors indicated that, without the use of prophylactic antiemetic therapy, chemotherapy can trigger severe nausea and vomiting, which can lead patients to wish to stop treatment. (11) Besides the negative impact on quality of life and influence on adherence to treatment, emesis may exert a burden on the health system, generating increased costs, whether with other medicines, unscheduled medical consultations, and hospitalizations that may be required. (11) The goal of antiemetic therapy is the complete prevention of emesis.…”

“…(11) Besides the negative impact on quality of life and influence on adherence to treatment, emesis may exert a burden on the health system, generating increased costs, whether with other medicines, unscheduled medical consultations, and hospitalizations that may be required. (11) The goal of antiemetic therapy is the complete prevention of emesis. In this context, adherence to new practices that enable better control of symptoms becomes necessary.…”

“…Studies have shown that combinations of new drugs such as palonosetron (serotonin receptor antagonist of the second generation) and aprepitant (NK-1 receptor antagonist) can offer a better protection. (10,11,15) Apart from drugs, complementary medicines and integrative practices can be associated with treatment such as herbal medicines, homeopathy, acupuncture, relaxation, aromatherapy and others. It is noteworthy that in addition to having these services provided, patients should be counseled regarding their effectiveness and encouraged to carry them out.…”