Impact of Zinc Supplementation on Diarrheal Morbidity and Growth Pattern of Low Birth Weight Infants in Kolkata, India: A Randomized, Double-Blind, Placebo-Controlled, Community-Based Study

Sur, Dipika; Gupta, Deepak; Mondal, Sujit; Ghosh, Shalini; Manna, Byomkesh; Rajendran, K.; Bhattacharya, Sujit

doi:10.1542/peds.112.6.1327

Cited by 66 publications

(61 citation statements)

References 16 publications

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“…In a birth cohort of 100 LBW infants. Sur et al 7 found significant effect of zinc supplementation on weight, length and linear growth velocity at the end of 1 year only.…”

Section: Discussionmentioning

confidence: 97%

“…Zinc deficiency in infants has been shown to have an adverse impact on growth and immunity in many studies 2 . Several studies have demonstrated the benefit of zinc supplementation in low birth infants with regard to growth and prevention of infections [2][3][4][5][6][7] However, some studies have shown marginal or no effect 8 , It is with this view that the present study is undertaking to evaluate the effectiveness of zinc supplementation in LBW infants in our set up.…”

Section: Introductionmentioning

confidence: 99%

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To Study the Role of Zinc Supplementation on Growth of Low Birth Weight Infants

Sonawane

Patil

Gulati

et al. 2014

MVP Journal of Medical Science

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This was a randomized controlled trial undertaken to study the role of zinc supplementation on growth of low birth weight infants (b.wt≤2500 gm). Out of 120 LBW infants, 23 were excluded due to loss of follow up. The remaining 97 LBW eligible neonates were randomized in to 2 group (zinc & control group), zinc group were given zinc supplementation at a dose of 2 mg/kg/day for 8 weeks from enrollment. They were then followed up every 4 weeks up to 8 weeks. At each visit, detail anthropometry including e weight, length, and head circumference were recorded at each visit. The infants in the zinc group had significantly higher weight gain (p<0.000), length gain (p<0.000), linear growth velocity and head circumference at 8 weeks. We concluded that zinc supplementation at 2 mg/kg/day for 8 weeks in LBW infants improves their growth during infancy.

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“…In a birth cohort of 100 LBW infants. Sur et al 7 found significant effect of zinc supplementation on weight, length and linear growth velocity at the end of 1 year only.…”

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

To Study the Role of Zinc Supplementation on Growth of Low Birth Weight Infants

Sonawane

Patil

Gulati

et al. 2014

MVP Journal of Medical Science

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“…18 Previous studies, which were carried out in infants of 6 to 11 months, have shown similar results to the current trial but after continuous zinc supplementation. [19][20][21][22] One of these trials was carried out in a cohort of low birth weight infants. 20 Trials have also shown the effectiveness of continuous zinc prophylaxis among wider age groups (6-41 months and 6-35 months, respectively), but subgroup analysis for children ,12 months of age was not done.…”

Section: Discussionmentioning

confidence: 99%

Short-Course Prophylactic Zinc Supplementation for Diarrhea Morbidity in Infants of 6 to 11 Months

Malik

Devasenapathy

et al. 2013

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Randomized controlled trials have shown that zinc supplementation during diarrhea substantially reduces the incidence and severity. However, the effect of short-course prophylactic zinc supplementation has been observed only in children .12 months of age. WHAT THIS STUDY ADDS:The current study was able to show that short-course prophylactic zinc supplementation significantly reduced diarrhea morbidity in apparently healthy infants of 6 to 11 months even after 5 months of follow-up. abstract BACKGROUND: Zinc supplementation during diarrhea substantially reduces the incidence and severity of diarrhea. However, the effect of short-course zinc prophylaxis has been observed only in children .12 months of age. Because the incidence of diarrhea is comparatively high in children aged 6 to 11 months, we assessed the prophylactic effect of zinc on incidence and duration of diarrhea in this age group. METHODS:In this randomized, double-blind, placebo-controlled trial, we enrolled infants aged 6 to 11 months from an urban resettlement colony in Delhi, India, between January 1, 2011, and January 15, 2012. We randomly assigned 272 infants to receive either 20 mg of zinc or a placebo suspension orally every day for 2 weeks. The primary outcome was the incidence of diarrhea per child-year. All analyses were done by intention-to-treat. RESULTS:A total of 134 infants in the zinc and 124 in the placebo groups were assessed for the incidence of diarrhea. There was a 39% reduction (crude incident rate ratio [IRR] 0.61, 95% confidence interval [CI] 0.53-0.71) in episodes of diarrhea, 39% (adjusted IRR 0.61, 95% CI 0.54-0.69) in the total number of days that a child suffered from diarrhea, and reduction of 36% in duration per episode of diarrhea (IRR 0.64, 95% CI 0.56-0.74) during the 5 months of follow-up.CONCLUSIONS: Short-course prophylactic zinc supplementation for 2 weeks may reduce diarrhea morbidity in infants of 6 to 11 months for up to 5 months, in populations with high prevalence of wasting and stunting. Pediatrics 2013;132:e46-e52 AUTHORS:

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“…We excluded infants less than 6 months of age because results from nonspecific trials have shown the greatest effect among children older than 6 months. There have been studies demonstrating a positive effect of zinc supplementation among low birth weight and small for gestational age babies (Sazawal et al, 2001;Sur et al, 2003), but because those are very specific subsets of the infant population we did not include those estimates. Additional age-specific data would be helpful for subsequent analyses.…”

Section: Discussionmentioning

confidence: 99%

Global and regional child mortality and burden of disease attributable to zinc deficiency

2008

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Impact of Zinc Supplementation on Diarrheal Morbidity and Growth Pattern of Low Birth Weight Infants in Kolkata, India: A Randomized, Double-Blind, Placebo-Controlled, Community-Based Study

Abstract: The study showed that zinc supplementation had a beneficial impact on the incidence of diarrhea and also weight gain among LBW infants.

Cited by 66 publications

References 16 publications

To Study the Role of Zinc Supplementation on Growth of Low Birth Weight Infants

To Study the Role of Zinc Supplementation on Growth of Low Birth Weight Infants

Short-Course Prophylactic Zinc Supplementation for Diarrhea Morbidity in Infants of 6 to 11 Months

Global and regional child mortality and burden of disease attributable to zinc deficiency

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