Global and regional child mortality and burden of disease attributable to zinc deficiency

Walker, Christa L. Fischer; Ezzati, Majid; Black, Robert E.

doi:10.1038/ejcn.2008.9

Cited by 168 publications

(67 citation statements)

References 15 publications

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“…Marginal zinc deficiency has been suggested to influence multiple physiological systems due to the extensive involvement of zinc in numerous structural and biochemical functions of the body (Foster and Samman 2010); a significant proportion of the world's population may be at risk of marginal zinc deficiency (Samman 2007), a condition that contributes substantially to disease burden worldwide (Fischer Walker et al 2009). Despite being redox-inert, zinc can act as a pro-antioxidant and modulate oxidative stress by maintaining cell membrane integrity and regulating the functions of metallothionein (MT), superoxide dismutases, and glutathione (Maret 2003;Oteiza 2012).…”

Section: Introductionmentioning

confidence: 99%

Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

et al. 2015

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The usefulness of zinc transporter and metallothionein (MT) gene expressions to detect changes in zinc intake remains unclear. This pilot study aimed to determine the effects of zinc supplementation on zinc transporter and MT gene expressions in humans. Healthy adults (n = 39) were randomised to zinc treatment (ZT), receiving 22 mg Zn/day (n = 19), or no treatment (NT) (n = 20). Blood samples were collected on Days 0, 2, 7, 14, and 21. Plasma zinc and serum C-reactive protein concentrations were analysed. Gene expression of zinc transporters and MT in peripheral blood mononuclear cells was analysed using real-time PCR. Using repeated-measures ANOVA, MT-2A gene expression and fold change were found to be higher in the ZT group (P = 0.025 and P = 0.016, respectively) compared to the NT group, specifically at Day 2 (40 ± 18 % increase from baseline, P = 0.011), despite no significant increase in plasma zinc concentration. In a multiple regression model exploring the changes in gene expressions between Days 0 and 21, the change in MT-2A gene expression was correlated with changes in all zinc transporter expressions (r (2) = 0.54, P = 0.029); the change in ZIP1 expression emerged as a univariate predictor (P = 0.003). Dietary zinc intake was predictive of zinc transporter and MT expressions (P = 0.030). Physical activity level was positively correlated with baseline ZIP7 expression (r = 0.36, P = 0.029). The present study shows that MT-2A expression is related to changing expression of zinc transporter genes, specifically ZIP1, in response to zinc supplementation. The current report adds to our understanding of MT in the coordinated nature of cellular zinc homeostasis.

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Section: Introductionmentioning

confidence: 99%

Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

et al. 2015

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“…La deficiencia de micronutrientes también constituye un problema de salud pública en estos países. En el mundo la carencia nutricional más frecuente es la de hierro, manifestada por anemia, que afecta a 1,9 millones de personas en el mundo (Fischer et al, 2009). En Colombia la padecen 27,5% de los niños de 6 a 59 meses de edad, siendo significativamente mayor la prevalencia entre el grupo indígena (32,6%) y afrodescendiente (33,7%) que otros (26,3%); también 17,9% de mujeres gestantes y 7,6% de mujeres en edad fértil presentan esta afectación (Ministerio de la Protección Social e Instituto Colombiano de Protección Familiar, 2011).…”

Section: Introductionunclassified

Caracterización nutricional y determinación de ácido fítico como factor antinutricional del frijol caupí

2018

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© 2018 Agronomía Mesoamericana es desarrollada en la Universidad de Costa Rica y se encuentra licenciada con Creative Commons Reconocimiento-NoComercial-SinObraDerivada 3.0 Costa Rica. Para más información escríbanos a pccmca@ucr.ac.cr ResumenEn Córdoba, Montería, Colombia, la pobreza llega al 67,8%, con un subconsumo de alimentos generalizado en la región y se calcula que, en promedio, el consumo diario de calorías es inferior en 18,7%, por lo cual, es necesario conocer las características bromatológicas y factores anti nutricionales de materias primas regionales. El objetivo de este trabajo fue caracterizar nutricionalmente 43 genotipos de frijol caupí y cuantificar el ácido fítico de los mejores cultivares, a partir del fósforo orgánico suponiendo que una molécula de este ácido contenía seis moléculas de fósforo, en relación con el contenido de proteína y minerales. Los genotipos provenían del Programa de Mejoramiento Genético de la Universidad de Córdoba; la investigación se desarrolló desde el año 2012 al 2014. El testigo Criollo Córdoba tuvo el valor más alto en el contenido de ácido fítico (12,267±2,15 mg/g) y el cultivar L042 el más bajo (9,630±1,725 mg/g), lo que indica una mejoría en la biodisponibilidad de los minerales. El contenido de proteína tuvo un rango entre 22,05%±0,82 a 26,90%±1,76, y con mayor contenido las líneas L047, L042, L026, L029, L019 y L002. La cantidad de hierro varió entre 59,54%±24 y 77-177,90%±122,20, sobresaliendo los cultivares L042, L020, L001, L005, L057 y L047, que superaron al testigo. Los genotipos evaluados presentaron diferencias significativas (p≤0,05) en el contenido de fósforo y sus valores variaron de 4,64%±0,43 a 5,69%±0,38; ningún cultivar superó al testigo. En contenido de zinc, los cultivares no presentaron diferencias significativas (p≥0,05), y varió entre 43,46%±4,75 y 53,38%±10,81. El cultivar L042 fue el mejor en características nutricionales y de menor contenido de ácido fítico como sustancia anti nutricional, requeridas para sustituir las variedades de frijol caupí que se consumen actualmente.Palabras clave: composición de los alimentos, necesidades de nutrientes, valor nutritivo, Vigna unguiculata L. AbstractIn Cordoba, Monteria, Colombia, poverty reaches 67.8% of the population, with a generalized food under consumption in the region, and it is estimated that on average, the daily calorie intake is lower than an 18.7%, so, it is necessary to know the qualitative characteristics and the anti-nutritional factors of regional raw materials. The objective of this study was to nutritionally characterize 43 genotypes of cowpea beans and to quantify the phytic acid of the best cultivars based on the study of organic phosphorus content on the samples, assuming that one molecule of this acid contains six molecules of phosphorus, in relation to the protein content and minerals. The genotypes that IntroducciónEn Colombia, para el 2016 se llegó a 49 246 676 personas, de las cuales 13 789 069 se estima que viven en pobreza monetaria (DANE, 2016). En la región Caribe,...

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“…The recent Lancet series on maternal and child under nutrition concluded that zinc deficiency is responsible for about 4% of child mortality and disabilityadjusted life-years (Black et al, 2008). The consequences and manifestations of severe zinc deficiency in infants and children and adolescents can be retardation of linear growth and development, poor appetite, delayed sexual maturation and hypogonadism, frequent infections (Maret and Sandstead, 2008), alopecia, dermatitis, delayed wound healing, diarrhoea, pneumonia, malaria (Fischer Walker et al, 2009), limitation on the senses of taste and smell, night blindness (Christian et al, 2001;Seiler et al, 2002). Zn deficiency may be associated with deficits in activity, attention, and motor development (Bhatnagar and Taneja, 2001).…”

Section: Introductionmentioning

confidence: 99%

EURRECA—Estimating Zinc Requirements for Deriving Dietary Reference Values

Hurst

Collings

Harvey

et al. 2013

Critical Reviews in Food Science and Nutrition

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Zinc was selected as a priority micronutrient for EURRECA, because there is significant heterogeneity in the Dietary Reference Values (DRVs) across Europe. In addition, the prevalence of inadequate zinc intakes was thought to be high among all population groups worldwide, and the public health concern is considerable. In accordance with the EURRECA consortium principles and protocols, a series of literature reviews were undertaken in order to develop best practice guidelines for assessing dietary zinc intake and zinc status. These were incorporated into subsequent literature search strategies and protocols for studies investigating the relationships between zinc intake, status and health, as well as studies relating to the factorial approach (including bioavailability) for setting dietary recommendations. EMBASE (Ovid), Cochrane Library CENTRAL and MEDLINE (Ovid) databases were searched for studies published up to February 2010 and collated into a series of Endnote databases that are available for the use of future DRV panels. Meta-analyses of data extracted from these publications were performed where possible in order to address specific questions relating to factors affecting dietary recommendations. This review has highlighted the need for more high quality studies to address gaps in current knowledge, in particular the continued search for a reliable biomarker of zinc status and the influence of genetic polymorphisms on individual dietary requirements. In addition, there is a need to further develop models of the effect of dietary inhibitors of zinc absorption and their impact on population dietary zinc requirements.

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Global and regional child mortality and burden of disease attributable to zinc deficiency

Cited by 168 publications

References 15 publications

Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

Caracterización nutricional y determinación de ácido fítico como factor antinutricional del frijol caupí

EURRECA—Estimating Zinc Requirements for Deriving Dietary Reference Values

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