Impact of zinc supplementation on the improved fructose/xylose utilization and butanol production during acetone–butanol–ethanol fermentation

Wu, Youduo; Xue, Chuang; Chen, Lijie; Bai, Feng‐Wu

doi:10.1016/j.jbiosc.2015.05.003

Cited by 20 publications

(5 citation statements)

References 41 publications

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“…As known, glucose and fructose are taken up through the phosphoenolpyruvate (PEP)dependent phosphotransferase system (PTS). After transported by PTS Fru , which belongs to the fructose/mannitol PTS permease family, 31 fructose is concomitantly phosphorylated to fructose-1-phosphate (F-1-P). Before entering in the glycolysis, F-1-P is converted into fructose-1,6-bisphosphate (FBP) by 1phosphofructokinase (1-PFK, FruB).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Clostridium sp. Strain NJ4: A Promising Solventogenic Strain for Butanol Production from Jerusalem Artichoke through Consolidated Bioprocessing

Jiang

Michenfelder

et al. 2020

Energy Fuels

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Clostridium sp. strain NJ4 was successfully isolated and characterized, which exhibited a wide carbon utilization spectrum, including glucose, fructose, fructooligosaccharide, and Jerusalem artichoke. In comparison to 14.71 and 15.81 g L–1 butanol produced from glucose and fructose, a similar butanol production was obtained by strain NJ4 from fructooligosaccharide and Jerusalem artichoke without supplementation of exogenous inulinases, owing to its efficient expression of levanase and fructan β-fructosidase. After the process optimization, 13.25 g L–1 butanol was directly produced from 90 g L–1 Jerusalem artichoke, indicating that strain NJ4 could be a promising candidate for butanol production from Jerusalem artichoke through consolidated bioprocessing (CBP) at a large scale. In addition, extra supplementation of sodium butyrate could improve butanol and acetone–butanol–ethanol titers to 14.35 and 24.75 g L–1. To the best of our knowledge, this represents the highest butanol production from Jerusalem artichoke through CBP.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Clostridium sp. Strain NJ4: A Promising Solventogenic Strain for Butanol Production from Jerusalem Artichoke through Consolidated Bioprocessing

Jiang

Michenfelder

et al. 2020

Energy Fuels

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“…Additional increases in zinc concentration were not helpful. This same strategy of supplementing with 3.5 µM Zn 2+ increased butanol titers from fructose by nearly threefold and also improved butanol titers on xylose and on sugar mixtures (Wu et al., 2016 ).…”

Section: Trace Metals and Mineralsmentioning

confidence: 97%

“…Co-supplementation of C. acetobutylicum with 3.5 µM Zn 2+ and 40 mM Ca 2+ improved butanol and ABE productivity from glucose, from xylose, and from glucose/xylose mixtures more than supplementation with either Zn 2+ or Ca 2+ alone (Wu et al., 2016 ). The fact that the addition of these two media components roughly doubled the organism's productivity without negatively impacting yield demonstrated the benefit of taking the time to perform these media optimization experiments.…”

Section: Trace Metals and Mineralsmentioning

confidence: 99%

Strategic nutrient sourcing for biomanufacturing intensification

Noroozi,

Jarboe

2023

Journal of Industrial Microbiology and Biotechnology

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The successful design of economically viable bioprocesses can help to abate global dependence on petroleum, increase supply chain resilience, and add value to agriculture. Specifically, bioprocessing provides the opportunity to replace petrochemical production methods with biological methods and to develop novel bioproducts. Even though a vast range of chemicals can be biomanufactured, the constraints of economic viability, especially while competing with petrochemicals, are severe. There have been extensive gains in our ability to engineer microbes for improved production metrics and for utilization of target carbon sources. The impact of growth medium composition on process cost and organism performance receives less attention in the literature than organism engineering efforts, with media optimization often being performed in proprietary settings. The widespread use of corn steep liquor (CSL) as a nutrient source demonstrates the viability and importance of ‘waste’ streams in biomanufacturing. There are other promising waste streams that can be used to increase the sustainability of biomanufacturing, such as the use of urea instead of fossil fuel-intensive ammonia, and the use of struvite instead of contributing to the depletion of phosphate reserves. In this review, we discuss several process-specific optimizations of micronutrients that increased product titers by 2-fold or more. This practice of deliberate and thoughtful sourcing and adjustment of nutrients can substantially impact process metrics. Yet the mechanisms are rarely explored, making it difficult to generalize results to other processes. In this review, we will discuss examples of nutrient sourcing and adjustment as a means of process improvement.

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“…As a result, glucose/xylose utilisation, cell growth, acid re-assimilation and butanol biosynthesis were significantly improved, with butanol and ABE production increased from 11.7 and 19.4 g L −1 to 16.1 and 25.9 g L −1 , respectively, from 69.3 g L −1 glucose. 128 Similarly, semi-hydrolysates with low enzyme loading using H 2 SO 4 -pretreated rice straw was also employed to further improve butanol fermentation efficiency through preferential production of cellobiose and xylose (instead of glucose). As a result, butanol productivity was correspondingly increased from 0.0628 g L −1 h −1 to 0.265 g L −1 h −1 during fermentation of undetoxified semi-hydrolysates with a high cell density.…”

Section: Limitations and Alleviation Strategies For Lignocellulosic B...mentioning

confidence: 99%

Production of butanol from lignocellulosic biomass: recent advances, challenges, and prospects

et al. 2022

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Impact of zinc supplementation on the improved fructose/xylose utilization and butanol production during acetone–butanol–ethanol fermentation

Cited by 20 publications

References 41 publications

Clostridium sp. Strain NJ4: A Promising Solventogenic Strain for Butanol Production from Jerusalem Artichoke through Consolidated Bioprocessing

Clostridium sp. Strain NJ4: A Promising Solventogenic Strain for Butanol Production from Jerusalem Artichoke through Consolidated Bioprocessing

Strategic nutrient sourcing for biomanufacturing intensification

Production of butanol from lignocellulosic biomass: recent advances, challenges, and prospects

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