Impact of weight loss on markers of systemic inflammation in obese Saudi children with asthma

El-Kader, M S Abd; Al-Jiffri, Osama H; Ashmawy, Eman M

doi:10.4314/ahs.v13i3.23

Cited by 29 publications

(41 citation statements)

References 33 publications

(36 reference statements)

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“…Confirming the impact of weight loss or body fat percentage on the inflammatory profile, especially in obese people (31,32), the findings of the present study showed that regular aerobic training for 12 weeks significantly reduced the inflammatory cytokines of obese women. Therefore, the significant reduction of IL-6 serum after 12 weeks aerobic training may be attributed to changes in weight and body fat percentage compared to pre-exercise levels.…”

Section: Discussionsupporting

confidence: 84%

Improved glucose and IL-6 by aerobic training despite no change in insulin and insulin resistance in obese women

Eizadi

Farbod

Goodarzi

et al. 2017

Avicenna J Med Biochem

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Background: Regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile. Objectives: This exercise aimed to determine the effect of aerobic training on serum interleukin-6 (IL-6), glucose and insulin resistance in obese females. Patients and Methods: Thirty-two middle-aged obese women (body mass index [BMI], 32 ± 3 kg/m2) aged 35 to 45 years were randomly assigned to exercise (aerobic training, n=16) and control (n=16) groups. Exercise subjects were completed a 12 weeks aerobic training program as 3 sessions per week at 60%-80% of HRmax and control subjects received no training. Pre- and post-training of fasting serum IL-6, insulin, insulin resistance, and glucose concentration were measured and compared between 2 groups. Results were compared using t test at a significance level of P<0.05. Results: Exercise group obtained significant decreases in BMI, body fat %, and abdominal obesity as well as the concentrations of serum IL-6 and fasting glucose (P<0.05). No significant difference was observed between pre- and post-training of insulin and insulin resistance in the exercise group (P >0.05). There were no alterations in these variables in the control group (P>0.05). Conclusions: These data suggest that aerobic training may improve glycemic profile in absence of change in insulin resistance of women with abdominal obesity

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Section: Discussionsupporting

confidence: 84%

Improved glucose and IL-6 by aerobic training despite no change in insulin and insulin resistance in obese women

Eizadi

Farbod

Goodarzi

et al. 2017

Avicenna J Med Biochem

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“…In addition, renal arterial endothelial function was blunted when incubated in vitro with perirenal fat harvested from MetS pigs, and restored by TNF-α inhibitor, substantiating its injurious effect on the renal vasculature. [39] Weight loss improves both inflammatory (CRP, TNF-α, IL-6 and leptin) and anti-inflammatory (adiponectin) markers in human subjects[40, 41], and MetS rats treated with anti-inflammatory mycophenolate mofetil showed reduced systemic and renal inflammation and limited renal fibrosis. [35] Therefore, measures to control inflammation in MetS may be beneficial for the kidney.…”

Section: Inflammation and Insulin Resistancementioning

confidence: 99%

The metabolic syndrome and chronic kidney disease

Zhang¹,

Lerman²

2017

Translational Research

112

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The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including insulin resistance (IR), dyslipidemia and hypertension, which may also foster development of chronic kidney disease. The mechanisms of MetS-induced kidney disease are not fully understood. The purpose of this review is to summarize recent discoveries regarding the impact of MetS on the kidney, particularly on the renal microvasculature and cellular mitochondria. Fundamental manifestations of MetS include insulin resistance (IR) and adipose tissue expansion, the latter promoting chronic inflammation and oxidative stress that exacerbate IR. Those in turn can elicit various kidney injurious events through endothelial dysfunction, activation of the renin-angiotensin-aldosterone system, and adipokine imbalance. IR and inflammation are also major contributors to microvascular remodeling and podocyte injury. Hence, these events may result in hypertension, albuminuria, and parenchymal damage. In addition, dyslipidemia and excessive nutrient availability may impair mitochondrial function and thereby promote progression of kidney cell damage. Elucidation of the link between MetS and kidney injury may help develop preventative measures and possibly novel therapeutic targets to alleviate and avert development of renal manifestations.

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“…A few studies have specifically focused on the impact of weight-loss interventions in obese-asthmatic children (2;65;112) suggesting improvements in lung function, inflammatory biomarkers, and exercise-induced bronchoconstriction. However, these studies have several limitations, including small sample sizes and short follow-up time.…”

Section: Therapeutic Approachesmentioning

confidence: 99%

Obesity, Asthma, and Exercise in Child and Adolescent Health

Manoukian

Radom‐Aizik

et al. 2016

Pediatric Exercise Science

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Obesity increases the risk of asthma throughout life but the underlying mechanisms linking these all too common threats to child health are poorly understood. Acute bouts of exercise, aerobic fitness, and levels of physical activity clearly play a role in the pathogenesis and/or management of both childhood obesity and asthma. Moreover, both obesity and physical inactivity are associated with asthma symptomatology and response to therapy (a particularly challenging feature of obesity-related asthma). In this article, we review current understandings of the link between physical activity, aerobic fitness and the asthma-obesity link in children and adolescents (e.g., the impact of chronic low-grade inflammation, lung mechanics, and direct effects of metabolic health on the lung). Gaps in our knowledge regarding the physiological mechanisms linking asthma, obesity and exercise are often compounded by imprecise estimations of adiposity and challenges of assessing aerobic fitness in children. Addressing these gaps could lead to practical interventions and clinical approaches that could mitigate the profound health care crisis of the increasing comorbidity of asthma, physical inactivity, and obesity in children.

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Impact of weight loss on markers of systemic inflammation in obese Saudi children with asthma

Cited by 29 publications

References 33 publications

Improved glucose and IL-6 by aerobic training despite no change in insulin and insulin resistance in obese women

Improved glucose and IL-6 by aerobic training despite no change in insulin and insulin resistance in obese women

The metabolic syndrome and chronic kidney disease

Obesity, Asthma, and Exercise in Child and Adolescent Health

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