Impact of Wait Times on Survival for Women With Uterine Cancer

Abstract

To the best of our knowledge, this is the first report in a large population-based cohort demonstrating that longer wait times from diagnosis of uterine cancer to definitive surgery have a negative impact on overall survival.

Effect of Treatment Delay on Survival in Patients With Cervical Cancer: A Historical Cohort Study

“…Patients with worse prognoses might often be considered to be higher priority and therefore have reduced waiting times. In a recent study by Elit et al, 21 endometrial cancer patients who had waited less than 2 weeks between diagnosis and treatment initiation turned out to have the worst 5-year survival rates. In those patients, the rates of acute presentation and emergent/ weekend surgery were higher, and disease at diagnosis had been more advanced and had been characterized by a higher rate of histology types considered to be biologically aggressive (such as uterine sarcoma) than in patients with longer waiting times.…”

Efeito do tempo de espera para radioterapia na sobrevida geral em cinco anos de mulheres com câncer do colo do útero, 1995-2010

“…O enfoque em tumores de diferentes topografias, submetidos a diferentes esquemas terapêuticos, sob diferentes definições de tempo de espera e de desfechos, acaba por dificultar a comparabilidade entre os estudos. No Canadá, pesquisas restritas à população de mulheres mostraram, por exemplo, que a demora acima de duas semanas está associada a pior prognóstico na sobrevida em cinco anos de mulheres com câncer do corpo do útero tratado por cirurgia 11 . No Reino Unido, a avaliação de tumores originados na mama não evidenciou efeito estatisticamente significativo do tempo de espera de 25 a 38 dias e de 39 a 62 dias, no risco de morte em cinco anos de mulheres tratadas cirurgicamente, comparando-se com espera menor que 25 dias 12 .…”

Determinants of treatment waiting times for head and neck cancer in the Netherlands and their relation to survival

“…The major concern arises when waiting for treatment causes progression of disease, decreased tumor control, more extensive treatment, increased costs and impaired survival. Several studies explored this relationship in different cancer sites and found a correlation with prognosis in patients with uterine [14], and breast [15] hand, in colorectal [16] and bladder [17] cancer, there was no or little evidence for this association.…”