Impact of volume guarantee on synchronized ventilation in preterm infants: a randomized controlled trial

Duman, Nuray; Tüzün, Funda; Sütçüoğlu, Sümer; Yesilirmak, Cemile Didem; Kumral, Abdullah; Özkan, Hasan

doi:10.1007/s00134-012-2601-5

Cited by 28 publications

(35 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(61). One trial did not define the follow up period (27) and one trial did not measure mortality (43). Two trials measured survival, at 1-year (31) and at an undefined time point (32).…”

Section: Resultsmentioning

confidence: 99%

How Outcomes Are Defined in Clinical Trials of Mechanically Ventilated Adults and Children

Blackwood

Clarke

McAuley

et al. 2014

Am J Respir Crit Care Med

View full text Add to dashboard Cite

“…(61). One trial did not define the follow up period (27) and one trial did not measure mortality (43). Two trials measured survival, at 1-year (31) and at an undefined time point (32).…”

Section: Resultsmentioning

confidence: 99%

How Outcomes Are Defined in Clinical Trials of Mechanically Ventilated Adults and Children

Blackwood

Clarke

McAuley

et al. 2014

Am J Respir Crit Care Med

View full text Add to dashboard Cite

“…A respirációs kezelés mechanikai hatása a tüdő szöve-tén nyomot hagy [38]. Önmagában a tüdő szövetének feszülése infl ammációs folyamatot indít el.…”

Section: A Respirációs Kezelés Mint a Bpd Egyik Rizikófaktoraunclassified

Chronic morbidities of premature newborns

Balla

Szabó

2013

Orvosi Hetilap

View full text Add to dashboard Cite

A retinopathia prematurorum, a bronchopulmonalis dysplasia, az intraventricularis haemorrhagia és a periventricularis leukomalacia a koraszülöttek legfontosabb krónikus utóbetegségei, amelyek alapvetően befolyásolják a gyermekek életminőségét. Mivel Magyarországon a koraszülés gyakorisága az elmúlt években nem csökkent, és a kialakult kórképek nehezen kezelhetők, a megelőzés jelentősége óriási. Kockázatifaktor-elemzések bebizonyították, hogy mindegyik kórkép multifaktoriális, a számos közös kóroki tényező közül a fejlődő szervek angiogenesise az egyik legfontosabb. A koraszülés következtében számos stresszhatás miatt károsodhat az érfejlődés. A megszületés után, a méhen belüli élethez viszonyítva, a relatív hyperoxia és a csökkenő vascularis növekedési faktorok szintje érsérü-lést, akár vascularis apoptózist okozhat. Mindezek következtében, a folyamat későbbi fázisában, a hypoxia által indukált gének aktiválódnak, óriási mértékű és kóros neovascularisatio, krónikus szervkárosodás alakul ki. A normális angiogenesis megtartása és a reaktív neovascularisatio gátlása a koraszülöttek jobb életminőségét eredményezheti. Orv. Hetil., 2013, 154, 1498-1511 Kulcsszavak: retinopathia prematurorum, bronchopulmonalis dysplasia, intraventricularis haemorrhagia, periventricularis leukomalacia Chronic morbidities of premature newbornsThe most important chronic morbidities of premature newborns, deeply infl uencing quality of life, are retinopathy of prematurity, bronchopulmonary dysplasia, intraventricular hemorrhage and periventricular leukomalacia. Since the rate of premature birth has not decreased in recent years in Hungary, and treatments of these end stage disorders are extremely diffi cult, prevention gains tremendous signifi cance. Effective prevention is based on detailed knowledge of the pathophysiological mechanisms of these special diseases having multifactorial nature sharing several common risk factors, and one is the pathological angiogenesis. This sensitive system is affected by several stress situations which are the consequences of prematurity leading to abnormal vascular growth. After birth, relative hyperoxia, compared to intrauterine life, and decreasing concentrations of vascular growth factors result in vascular injury, moreover, may cause vessel apoptosis. The consequence of this phenomenon is the activation of hypoxia responsible genes resulting in robust pathological neovascularization and organ damage during the later phase. Saving normal angiogenesis and inhibiting reactive neovascularization may lead to better quality of life in these premature infants. Orv. Hetil., 2013, 154, 1498-1511 Keywords: retinopathy of prematurity, bronchopulmonary dysplasia, intraventricular haemorrhage, periventricular leukomalacia (Beérkezett: 2013. augusztus 6.; elfogadva: 2013. augusztus 22.) A szerkesztőség felkérésére készült közlemény. Rövidítések ANGPT-2 = angiopoetin-2; β-ARs = béta-adrenerg receptorok; BPD = bronchopulmonalis dysplasia; CP = cerebral palsy; ELBW = (extremely low birthweight) extrém kis születés...

show abstract

“…Volume-targeted ventilation is known to improve neonatal prognosis in preterm infants when added to conventional ventilation [7,8]. However, volume-targeted ventilation combined with high-frequency ventilation has not been adequately evaluated.…”

Section: Introductionmentioning

confidence: 99%

Impact of Volume Guarantee on High-Frequency Oscillatory Ventilation in Preterm Infants: A Randomized Crossover Clinical Trial

İşcan¹,

Duman²,

Tüzün³

et al. 2015

Neonatology

Self Cite

View full text Add to dashboard Cite

Background: High-frequency oscillatory ventilation (HFOV) with volume guarantee (VG) is a new ventilation mode that allows the clinician to set a mean tidal volume to be delivered. Objective: This study aimed to investigate whether HFOV with a VG option may result in constant tidal volume delivery and less fluctuant CO₂ levels compared to HFOV alone in premature infants with respiratory distress syndrome (RDS). Methods: Inborn infants at less than 32 weeks of gestation with RDS requiring invasive mechanical ventilation were eligible. Patients were randomized to receive HFOV + VG or HFOV alone as the initial ventilator mode and then crossed over to the other mode. HFOV was performed with ‘optimal lung volume strategy' during both of the periods. Results: Twenty infants were evaluated. The mean high-frequency tidal volume (VT_hf) and CO₂ diffusion coefficient (DCO₂) were significantly higher in the HFOV + VG mode than HFOV alone. HFOV + VG maintains VT_hf within the target range more consistently than HFOV. The incidences of hypocarbia and hypercarbia were lower in HFOV with VG than HFOV alone. Conclusion: This is the first prospective, randomized, short-term crossover clinical study that compared HFOV with and without VG in infants with acute RDS. Because of the lower VT_hf fluctuation and lower incidences of out-of-target PCO₂ levels, HFOV combined with VG seems to be feasible for preterm infants. However, the results should be interpreted with caution due to the small sample size and short-term crossover design of the study.

show abstract

Impact of volume guarantee on synchronized ventilation in preterm infants: a randomized controlled trial

Cited by 28 publications

References 18 publications

How Outcomes Are Defined in Clinical Trials of Mechanically Ventilated Adults and Children

How Outcomes Are Defined in Clinical Trials of Mechanically Ventilated Adults and Children

Chronic morbidities of premature newborns

Impact of Volume Guarantee on High-Frequency Oscillatory Ventilation in Preterm Infants: A Randomized Crossover Clinical Trial

Contact Info

Product

Resources

About