Impact of vitamin D supplementation on markers of bone mineral metabolism in term infants

Czech‐Kowalska, Justyna; Płudowski, Paweł; Dobrzańska, Anna; Kryśkiewicz, Edyta; Karczmarewicz, Elżbieta; Gruszfeld, Dariusz; Pleskaczyńska, Agata; Golkowska, Malgorzata

doi:10.1016/j.bone.2012.06.023

Cited by 21 publications

(30 citation statements)

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“…Another interesting observation relates to PTH as a functional marker of vitamin D status in adults, children and infants but not necessarily in neonates [44]–[47]. We found no correlation between 25(OH)D and iPTH in cord blood, which is in agreement with previous reports [44], [48], [49].…”

Section: Discussionsupporting

confidence: 92%

Impact of Vitamin D Supplementation during Lactation on Vitamin D Status and Body Composition of Mother-Infant Pairs: A MAVID Randomized Controlled Trial

et al. 2014

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ObjectiveThe optimal vitamin D intake for nursing women is controversial. Deterioration, at least in bone mass, is reported during lactation. This study evaluated whether vitamin D supplementation during lactation enhances the maternal and infant’s vitamin D status, bone mass and body composition.Design and MethodsAfter term delivery, 174 healthy mothers were randomized to receive 1200 IU/d (800 IU/d+400 IU/d from multivitamins) or 400 IU/d (placebo+400 IU/d from multivitamins) of cholecalciferol for 6 months while breastfeeding. All infants received 400 IU/d of cholecalciferol. Serum 25-hydroxyvitamin D [25(OH)D], iPTH, calcium, urinary calcium, and densitometry were performed in mother-offspring pairs after delivery, and at 3 and 6 months later.ResultsA total of 137 (79%) (n = 70; 1200 IU/d, n = 67; 400 IU/d) completed the study. 25(OH)D was similar in both groups at baseline (13.7 ng/ml vs. 16.1 ng/ml; P = 0.09) and at 3 months (25.7 ng/ml vs. 24.5 ng/ml; P = 0.09), but appeared higher in the 1200 IU/d group at 6 months of supplementation (25.6 ng/ml vs. 23.1 ng/ml; P = 0.009). The prevalence of 25(OH)D <20 ng/ml was comparable between groups at baseline (71% vs. 64%, P = 0.36) but lower in the 1200 IU/d group after 3 months (9% vs. 25%, P = 0.009) and 6 months (14% vs. 30%, P = 0.03). Maternal and infants’ iPTH, calciuria, bone mass and body composition as well as infants’ 25(OH)D levels were not significantly different between groups during the study. Significant negative correlations were noted between maternal 25(OH)D and fat mass (R = −0.49, P = 0.00001), android fat mass (R = −0.53, P = 0.00001), and gynoid fat mass (R = −0.43, P = 0.00001) after 6 months of supplementation.ConclusionsVitamin D supplementation at a dose of 400 IU/d was not sufficient to maintain 25(OH)D >20 ng/ml in nursing women, while 1200 IU/d appeared more effective, but had no effect on breastfed offspring vitamin D status, or changes in the bone mass and the body composition observed in both during breastfeeding.Trial RegistrationClinicalTrials.gov NCT01506557

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Section: Discussionsupporting

confidence: 92%

Impact of Vitamin D Supplementation during Lactation on Vitamin D Status and Body Composition of Mother-Infant Pairs: A MAVID Randomized Controlled Trial

et al. 2014

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“…Hungry bone syndrome may follow parathyroidectomy [46,47]. This condition is marked by extensive hypophosphataemia and hypocalcaemia, mostly refractory to oral supplementation [40][41][42][43][44][45][46][47]51].…”

Section: Discussionmentioning

confidence: 99%

Od preparowania czterogruczołowego do technik małoinwazyjnych. Małoinwazyjna paratyroidektomia jako obecny standard chirurgii pierwotnej nadczynności przytarczyc

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Proczko-Markuszewska

et al. 2014

Endokrynologia Polska

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Complete surgical resection of hyperfunctioning parathyriod tissue is essential for the treatment of primary hyperparathyroidism. During recent years, minimally invasive surgery has been successfully applied in neck exploration, because of significant developments of guidance by intraoperative scans, the use of quick, intraoperative PTH assay, and also preoperative imaging procedures such as highresolution ultrasonography and sestamibi scintigraphy. The results of operations which are performed with minimally invasive techniques are comparable to those of conventional surgery, and provide advantages with regard to cosmetic result, length of hospitalisation, and reduced post-operative pain. StreszczenieCałkowite chirurgiczne usunięcie nadczynnej tkanki gruczołowej jest kluczowe dla leczenia pierwotnej nadczynności przytarczyc. Podczas ostatnich lat, techniki chirurgii małoinwazyjnej były z sukcesem wprowadzane do preparowania tkanek szyi. Było to możliwe dzięki opracowaniu śródoperacyjnych metod lokalizowania zmienionej tkanki, szybkim testom oznaczającym stężenie PTH w surowiczy, jak również doskonaleniu technik obrazowania przedoperacyjnego, takich jak ultrasonografia wysokiej rozdzielczości czy scyntygrafia z wykorzystaniem sestamibi. Wyniki operacji z wykorzystaniem technik małoinwazyjnych są porównywalne z wynikami technik konwencjonalnych oraz wiążą się z zaletami, takimi jak skrócony okres hospitalizacji, zmniejszenie bólu pooperacyjnego czy lepszy efekt kosmetyczny. (Endokrynol Pol 2014; 65 (3): 240-249) Słowa kluczowe: pierwotna nadczynność przytarczyc; konwencjonalne preparowanie tkanek szyi; minimalnie inwazyjna parathyroidectomia

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“…Clarifying the major sources of circulating concentrations of CNP forms, as well as the effects of pathophysiological variables on plasma levels, is increasingly important now that laboratory assays are being used in humans to quantify CNP production (7,8,12). Values of both NTproCNP and CNP were higher during the growing years (9) and then fell and acutely ill subjects (Group 2).…”

Section: Discussionmentioning

confidence: 99%

“…Together, these findings indicate that the inflammatory response and/or the associated stress rapidly reduce CNP production in skeletal tissues. These findings not only provide new insights into CNP regulation but also on a more pragmatic note require consideration when interpreting plasma NTproCNP values as a marker of growth velocity.Clarifying the major sources of circulating concentrations of CNP forms, as well as the effects of pathophysiological variables on plasma levels, is increasingly important now that laboratory assays are being used in humans to quantify CNP production (7,8,12). Values of both NTproCNP and CNP were higher during the growing years (9) and then fell and acutely ill subjects (Group 2).…”

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Acute inflammation in young children inhibits C-type natriuretic peptide

et al. 2013

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Background: C-type natriuretic peptide (CNP) is a paracrine growth factor critical in endochondral bone growth. Amino-terminal CNP (NTproCNP), measurable in plasma, correlates with growth-plate activity and can be used as a biomarker of growth velocity in children. Because severe inflammation in adults increases CNP, we studied CNP peptides and inflammatory markers in children with acute illness. Methods: Forty-two children aged 2 mo to 5 y with acute illness warranting admission to an acute assessment unit were studied. Fifteen age-matched healthy children attending an outpatient clinic served as controls. Venous CNP concentrations were measured at admission, along with markers of acute inflammation (body temperature, C-reactive protein (CRP), and white blood cell count) in children with acute illness. results: NTproCNP and CNP SD scores (SDSs) in the acutely ill group were significantly suppressed (P < 0.001) as compared with those of healthy children or healthy population norms. NTproCNP SDS was significantly inversely related to body temperature (r = −0.42, P < 0.01) and CRP (r = −0.56, P < 0.001). conclusion: Acute inflammation in young children potently reduces CNP production, which needs to be considered when screening for growth disorders. Our data raise the possibility that the adverse effects of inflammatory cytokines on skeletal growth may be mediated in part by reduced CNP. c -type natriuretic peptide (CNP) is expressed in a wide range of tissues (1), but its regulation in vivo has been difficult to study because only small amounts of the active peptide enter the circulation. However, recognition that an inactive amino-terminal fragment of proCNP (NTproCNP) is co-secreted with CNP (2,3), is readily measured in plasma, and correlates with tissue CNP production (4), has opened the door to clinical studies-for example, study of changing CNP production during growth and development.In keeping with evidence showing that an intact CNP signaling pathway is crucial to postnatal endochondral growth (5,6), there is now strong support for the view that plasma concentrations of NTproCNP reflect concurrent linear growth velocity during childhood (3,7,8). Recent studies indicate that plasma NTproCNP concentration accounts for at least 50% of the variation in growth velocity in healthy children aged 2 mo to 20 y (9). Furthermore, changes in growth velocity initiated by hormone therapy (10) or glucocorticoid drugs (11) are closely correlated with concordant changes in plasma NTproCNP. Together, these findings suggest that, provided other pathophysiological variables are controlled, this peptide may be a useful marker of concurrent growth velocity. During the course of determining a provisional reference range for plasma CNP forms, we observed unusually low concentrations in very young children with intercurrent infections. This finding-unexpected in light of reports in adults showing that plasma CNP forms were raised in acute sepsis-raised the possibility that the CNP response to acute inflammation may differ in gro...

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Impact of vitamin D supplementation on markers of bone mineral metabolism in term infants

Cited by 21 publications

References 27 publications

Impact of Vitamin D Supplementation during Lactation on Vitamin D Status and Body Composition of Mother-Infant Pairs: A MAVID Randomized Controlled Trial

Impact of Vitamin D Supplementation during Lactation on Vitamin D Status and Body Composition of Mother-Infant Pairs: A MAVID Randomized Controlled Trial

Od preparowania czterogruczołowego do technik małoinwazyjnych. Małoinwazyjna paratyroidektomia jako obecny standard chirurgii pierwotnej nadczynności przytarczyc

Acute inflammation in young children inhibits C-type natriuretic peptide

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