Impact of Vitamin D on Proteinuria, Insulin Resistance, and Cardiovascular Parameters in Kidney Transplant Recipients

Lee, D.R.; Kong, Jin Min; Cho, K.I.; Chan, Laurence

doi:10.1016/j.transproceed.2011.08.081

Cited by 30 publications

(33 citation statements)

References 45 publications

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“…A low 25(OH)D level has been associated with an increased prevalence of albuminuria among the general adult population [21]. An inverse relationship has been reported between vitamin D level and proteinuria [12,22]. It is not well explained whether only urinary loss of vitamin D binding protein or 25(OH)D spontaneously contributed to vitamin D insufficiency.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Vitamin D Status and Graft Function in Renal Transplant Recipients

Erdem¹,

Yılmaz²,

Süleymanlar³

et al. 2017

Int J Med Biochem

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C hronic kidney disease (CKD), which has a high morbidity and mortality rate, negatively affects the quality of life. The incidence of the disease has increased significantly in recent years [1]. Renal replacement therapies, such as dialysis and renal transplantation, are implemented for patients with CKD. In renal transplantation patients, survival and quality of life is improved markedly compared with dialysis patients, and less cardiovascular disease is observed [2]. However, there is still a high risk for acute rejection and chronic allograft nephropathy in renal transplantation [3,4]. Due to the increasing importance of the renal transplantation, it is very important to reduce major risk factors involved in graft failure. Vitamin D, which plays an important role in the regulation of calcium, phosphorus, and bone metabolism, is a steroid hormone. It is obtained through nutrition and solar radiation. Two hydroxylation steps are required to convert it to the physiologically active form of vitamin D (1,25-dihydroxyvitamin D, calcitriol). The first step occurs in the liver, producing 25-hydroxyvitamin D3 , and plasma 1,25(OH)2D3 levels were measured. In addition, the urine protein/creatinine (P/C) ratio was calculated. The plasma 1,25(OH)2D3 level was determined using liquid chromatography-tandem mass spectrometry. Results: The posttransplant level of serum phosphorus, PTH, creatinine, BUN and ALP was found to be significantly decreased (p=0.0001; p=0.011 for ALP). Although the plasma 1,25(OH)2D3 level had significantly increased (p=0.0001) after transplantation, no significant difference in the serum 25(OH)D level was observed. The urine P/C ratio was found to be significantly decreased after transplantation (p=0.007). A deficiency of vitamin D was observed frequently both before (87%) and after (73%) transplantation. Conclusion: Persistent vitamin D deficiency was detected in the recipients even after transplantation, although the serum PTH level decreased. Some studies published to date draw a direct link between serum vitamin D level and graft function; however, evidence for this link was not observed in the present study. Long-term monitoring may be needed to evaluate the correlation between vitamin D level and graft function. Keywords: 1,25-dihydroxyvitamin D3, graft function, liquid chromatography-tandem mass spectrometry, protein/creatinine ratio, renal transplantation, vitamin D Research ArticleThe relationship between vitamin D status and graft function in renal transplant recipients

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Vitamin D Status and Graft Function in Renal Transplant Recipients

Erdem¹,

Yılmaz²,

Süleymanlar³

et al. 2017

Int J Med Biochem

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“…However, Lee and associates reported a significant association between vitamin D insufficiency and proteinuria in kidney transplant recipients. 13 The few studies that investigated treatment with vitamin D and its influence on proteinuria and renal function have shown conflicting results. O'Herrin and associates demonstrated that calcitriol treatment had beneficial effects on renal graft function.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Filipov

Zlatkov²,

Dimitrov³

et al. 2016

Exp Clin Transplant

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“…Better VD status was associated with lower mortality in the general population and CKD patients, including patients on hemodialysis [98][99][100]. However, there are no data in terms of mortality in patients after renal transplantation.…”

Section: Vitamin D and Mortality After Ktxmentioning

confidence: 99%

“…In the setting of renal transplantation, low VD was associated with higher proteinuria [98]. In addition, calcitriol therapy was found beneficial for renal graft function [99].…”

Section: Vitamin D and Renoprotection After Ktxmentioning

confidence: 99%

Vitamin D and Renal Disease

Filipov¹,

Zlatkov²,

Dimitrov³

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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The metabolism of vitamin D (VD) is severely impaired in chronic kidney disease (CKD). Uremia is not only associated with the reduction of its active form 1,25-dihydroxyvitamin D but also in the reduction of all VD metabolites. CKD-associated abnormalities in VD are part of the CKD-related mineral-bone disease. However, VD has beneficial effect on the kidneys due to its pleiotropic effects, namely, antiproteinuric effect and reninangiotensin-aldosterone system suppression, thus making the relationship between VD and the kidney even more complicated. The aim of our chapter is to reveal the changes in vitamin D axis in CKD, to outline the possible beneficial effects of vitamin D in renal patients, including end-stage renal patients and kidney transplant recipients, and to address the current opinions concerning treatment with cholecalciferol, calcitriol, and vitamin D analogs.

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Impact of Vitamin D on Proteinuria, Insulin Resistance, and Cardiovascular Parameters in Kidney Transplant Recipients

Cited by 30 publications

References 45 publications

The Relationship Between Vitamin D Status and Graft Function in Renal Transplant Recipients

The Relationship Between Vitamin D Status and Graft Function in Renal Transplant Recipients

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Vitamin D and Renal Disease

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