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Filipov, Jean; Zlatkov, Б.; Dimitrov, Emil; Svinarov, Dobrin

doi:10.6002/ect.2015.0344

Cited by 5 publications

(2 citation statements)

References 27 publications

(24 reference statements)

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“…Vitamin D deficiency is associated with deteriorated kidney function and worse long-term clinical outcomes [ 49 ] that can be due to the higher rates of rejection episodes and proteinuria onset [ 50 ]. Filipov et al demonstrated that poor vitamin D status results in higher proteinuria after kidney transplantation [ 51 ]. The possible antiproteinuric mechanisms of vitamin D are the inhibition of the renin–angiotensin–aldosterone system (RAAS), nuclear factor κΒ (NFKB1) inactivation, Wnt/β catenin (WNT1/CTNNB1) pathway suppression, and upregulation of slit-diaphragm proteins.…”

Section: Vitamin D and Kidney Transplantationmentioning

confidence: 99%

Vitamin D and the Kidney: Two Players, One Console

Zappulo

Cappuccilli

Cingolani

et al. 2022

IJMS

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Vitamin D belongs to the group of liposoluble steroids mainly involved in bone metabolism by modulating calcium and phosphorus absorption or reabsorption at various levels, as well as parathyroid hormone production. Recent evidence has shown the extra-bone effects of vitamin D, including glucose homeostasis, cardiovascular protection, and anti-inflammatory and antiproliferative effects. This narrative review provides an overall view of vitamin D’s role in different settings, with a special focus on chronic kidney disease and kidney transplant.

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Section: Vitamin D and Kidney Transplantationmentioning

confidence: 99%

Vitamin D and the Kidney: Two Players, One Console

Zappulo

Cappuccilli

Cingolani

et al. 2022

IJMS

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show abstract

“…In fact, urinary protein loss, which occurs with a certain frequency in KTx patients, is almost invariably associated with the loss of DBP in urine. This could be at least in theory followed by a reduction of the circulating levels of the DBP and of its specific ligand, namely vitamin D, increasing the occurrence of a deficiency/insufficiency status [46] However, the reduction of the total circulating amount does not necessarily translate into a real deficiency/insufficiency condition, since the free (active) fraction of vitamin D can still remain within the normal range. Furthermore, even the fall in the total circulating amount of vitamin D has been recently questioned by Doorenbos and coworkers [47], who, though confirming that proteinuria is invariably associated with a consistent urinary loss of the DBP, have not observed any significant change in both DBP and vitamin D total or free circulating levels.…”

Section: Epidemiology Of the Vitamin D Status In Ktx Recipientsmentioning

confidence: 99%

Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality

2017

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Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects.

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The Effect of Short-Term Vitamin D Supplementation on Calcium Status in Vitamin D Insufficient Renal Transplant Recipients at Risk of Hypercalcemia

Cronin

Byrne

Doyle

et al. 2019

Journal of Renal Nutrition

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Insufficient Renal Transplant Recipients at risk of Hypercalcaemia. Objective: Vitamin D insufficiency is highly prevalent amongst renal transplant recipients and in observational studies is associated with adverse outcomes. Hypercalcaemia, usually due to persistent hyperparathyroidism, also commonly occurs in this population and often coexists with vitamin D insufficiency. However, concern that vitamin D supplementation might exacerbate the pre-existing hypercalcaemia often leads clinicians to avoid vitamin D supplementation in such patients. This feasibility study aimed to quantify the effect on serum calcium of short-term lowdose cholecalciferol supplementation in a group of renal transplant recipients with a recent history of serum calcium levels >10 mg/dL. Design: This was a two-week, single arm, open-label trial. Setting: Renal transplant follow-up clinic in an Irish University Hospital. Subjects: 18 vitamin D insufficient adult patients with a functioning renal allograft (eGFR > 30 ml/min/1.73m 2) and a recent history of serum calcium>10mg/dL. Intervention: Two weeks of treatment with 1000 IU cholecalciferol/day. Main Outcome Measure: Change in plasma ionized calcium and urine calcium:creatinine ratio at follow-up as compared to baseline. Results: The mean (sd) baseline 25 (OH) vitamin D (25 (OH) D) concentration was 15.9 (5.97) ng/mL and the mean (sd) baseline serum calcium was 10.50 (0.6) mg/dL. Following the 2-week intervention, median (IQR) change in serum calcium from baseline to follow-up was-0.08 (-3.6 to 0.08) mg/dL, p=0.3. Mean (sd) ionized calcium decreased from 5.24 (0.32) mg/dL at baseline 4 to 5.16 (0.28) mg/dL, p= 0.05. The median (IQR) change in the urinary calcium:creatinine ratio was 0.001 (-0.026 to 0.299) mg/mg, p=0.88. The median (IQR) change in 25 (OH) D was 3.6 (2.9 to 6.2) ng/mL, p<0.05. Conclusions: In vitamin D insufficient renal transplant recipients at risk of hypercalcaemia, lowdose short-term oral cholecalciferol supplementation improves 25 (OH) D concentrations without exacerbating hypercalcaemia or increasing the urinary calcium:creatinine ratio.

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Untitled

Cited by 5 publications

References 27 publications

Vitamin D and the Kidney: Two Players, One Console

Vitamin D and the Kidney: Two Players, One Console

Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality

The Effect of Short-Term Vitamin D Supplementation on Calcium Status in Vitamin D Insufficient Renal Transplant Recipients at Risk of Hypercalcemia

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