Impact of Vitamin D in the Treatment of Tuberculosis

Vitamin D status in pediatric osteoarticular tuberculosis

“…Insufficiency of vitamin D may therefore impair the first-line defense mechanism of macrophage-initiated immune response against TB. 11 Vitamin D, therefore, may have a role in tubercular etiopathogenesis, and that tubercular patients have lower vitamin D concentrations has been demonstrated in both adult and pediatric studies. 1,3 Our study too supported the finding that hypovitaminosis D is associated with active TB in children including osteoarticular TB.…”

The human cytomegalovirus lytic cycle is induced by 1,25-dihydroxyvitamin D3 in peripheral blood monocytes and in the THP-1 monocytic cell line

“…Interestingly, blood leukocytes robustly express the VDR and results of studies performed in vitro in human myeloid cell lines and ex vivo in murine bone marrow cells have demonstrated that 1,25-dihydroxyvitamin D3 has the ability to induce monocyte-macrophage differentiation (Gemelli et al, 2008; Hmama et al, 1999; Lagishetty, Liu, and Hewison, 2011; Liu et al, 2006; O'Kelly et al, 2002, Bhalla, 1983 #83; Provvedini et al, 1983). It is therefore not surprising that 1,25-dihydroxyvitamin D3 has been demonstrated to exhibit antibacterial and antiviral effects (Korf, Decallonne, and Mathieu, 2014; Luong and Nguyen, 2011; Maxwell, Carbone, and Wood, 2012; Spector, 2011). The importance of 1,25-dihydroxyvitamin D3 in regulation of immune system function has been further highlighted by studies which suggest that 1,25-dihydroxyvitamin D3 or synthetic analogues of 1,25-dihydroxyvitamin D3 could be used as potent candidates for the treatment for autoimmune diseases, infectious diseases and anticancer therapies (Salomon et al, 2014; Yuzefpolskiy et al, 2014; Zhang, Wan, and Liu, 2013).…”

Impact of host gene polymorphisms on susceptibility to chronic hepatitis B virus infection

“…This binding activates the innate immunity systems and improves the immune responses through inhibiting the Th1 cell functions and activating the Th2 cells responses (Beard et al, 2011;Hewison, 2011). Low levels of vitamin D are associated to the viral infections (Cannell et al, 2006;Luong and Nguyen, 2011;Nnoaham and Clarke, 2008;Spector, 2011). The vitamin D receptor is expressed on the surface of monocytes and lymphocytes.…”