Vitamin D status in pediatric osteoarticular tuberculosis

Abstract

Active osteoarticular TB in children was also associated with hypovitaminosis D. The correlation between hypovitaminosis D and osteoarticular TB appears to be more disease specific rather than host specific.

Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis

“…An observational study conducted to assess the serum concentration of 25(OH)D among children with active tuberculosis (TB) using non-TB pneumonia and healthy controls revealed that larger number of vitamin D deficient children were from active TB group [ 9 ]. Similarly, many studies conducted elsewhere [ [10] , [11] , [12] , [13] , [14] ] delineated similar findings including Dabla's study conducted among pediatric osteoarticular tuberculosis patients which revealed that 56% of active TB cases were vitamin D deficient and had lower levels of serum 25(OH)D compared to healthy controls [ 11 ]. However, significant number of studies found no significant difference in vitamin D deficiency status TB patients and healthy children [ [15] , [16] , [17] ].…”

“…Vitamin D deficiency is associated with infection and increased autoimmunity [ 7 ]. Different studies among under five children shows that decreased level of 25(OH)D were more prevalent among under five children with respiratory tract infections (RTIs) and its deficiency was associated with increased risk of RTIs [ [8] , [9] , [10] ]. Furthermore, studies also shows that, normal to high serum 25(OH)D status appears to have some beneficial influence on the incidence and severity of some, though not all, types of infections [ [10] , [11] , [12] ].…”

The association between vitamin D status and tuberculosis in children

“…The included studies were published between 2012 and 2017. Four studies [20–23] described the difference in 25(OH)D levels in children with TB and controls; two [21,23] of these studies calculated 25(OH)D levels in nmol/L, and two [20,22] calculated 25(OH)D levels in ng/mL. Four studies [24–27] evaluated the association between the presence of any TB and VDD.…”

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

“…In India, three studies investigated serum 25(OH)D concentrations in children with osteoarticular TB [37,38] and intrathoracic TB [39]. Agarwal's study revealed hypovitaminosis D in 86% of patients while not discovering any discernible difference in 25(OH)D levels with respect to sex, age, or site of infection.…”