Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions

Honarbakhsh, Maryam; Ericsson, Aaron C.; Zhong, Guo; Isoherranen, Nina; Zhu, Chengsheng; Bromberg, Yana; Buiten, Charlene B. Van; Malta, Kiana; Joseph, Laurie B.; Sampath, Harini; Lackey, Atreju I.; Storch, Judith; Vetriani, Costantino; Chikindas, Michael L.; Breslin, Paul A.S.; Quadro, Loredana

doi:10.1016/j.jlr.2021.100046

Cited by 16 publications

(11 citation statements)

References 81 publications

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“…Vitamin A is an important micro-essential nutrient that is required for normal vision, cell growth, reproductive action, and preventing infection. It is critical for maintaining a plethora of mammalian biological functions [41,42]. Vitamin A was not detected in any sample, limit of detection being of 0.25 ppm.…”

Section: Resultsmentioning

confidence: 90%

Assessment of Balanites aegyptiaca and Sesamum indicum Artisanal Oils Quality and Vitamin Contents

Gueye¹,

Diaw²,

Ndiaye³

et al. 2022

SJAC

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In Senegal, artisanal vegetable oils trade is developing and Balanites aegyptiaca (desert date) as well as Sesamum indicum (sesame) are popular vegetal species. Present study focused on oils obtained from these two plants seeds. These oils have various applications such as for dietary and cosmetic purposes. Sampling carried out in Dakar region allowed collection of five oil samples for each specie, mainly in different districts shops or craft fairs. Their peroxide, acid, iodine and saponification values as well as volatile matter, tocopherols and vitamin A contents have been determined through reference methods described by International Organization for Standardization (ISO) or French Standardization Association (AFNOR). Obtained experimental data were compared with Codex Alimentarius standard and/or literature, since some parameters are not subject to specific regulation. Balanites aegyptiaca and Sesamum indicum oil samples showed an orange-yellow or pale yellow coloration. Only one desert date oil sample had an adequate peroxide value while two from sesame were not compliant. Iodine values for B. aegyptiaca samples were closed to a result previously described by peer researchers for an oil produced from seeds harvested in Senegal but out of Codex specification range for sesame oils. All ten samples had a suitable acidity, widely below maximum value of 4.0 mg KOH/g. Two sesame oil samples had correct saponification value. Among ten oil samples collected, eight showed a volatile matter content exceeding standard. Vitamin A had not been detected in any sample. Desert date oils tocopherols content were comprised between 975.38 and 1141.36 mg/kg and S. indicum samples met the standard indicating a tocopherols level in the range [330 -1010 mg/kg]. Present study results are not all conclusive and reinforce reservations about commercially available artisanal oils quality. However, literature review allows to state that oils physico-chemical properties and nutrient content vary greatly.

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Section: Resultsmentioning

confidence: 90%

Assessment of Balanites aegyptiaca and Sesamum indicum Artisanal Oils Quality and Vitamin Contents

Gueye¹,

Diaw²,

Ndiaye³

et al. 2022

SJAC

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“…Neither weight nor oral intake was affected by this method of asparaginase administration ( 25 ). Serum retinol and retinyl ester, the most abundant retinoid forms in the body, were measured using high-performance liquid chromatography (HPLC) ( 26 ). Serum retinyl ester was mostly undetectable.…”

Section: Resultsmentioning

confidence: 99%

“…Mice were euthanized about 8 hours after the final injection to obtain serum and liver samples. Serum retinol concentrations were measured using reversed-phase HPLC analysis ( 26 ). Liver tissue samples were sent to Metabolon for global metabolomic analyses ( 59 ).…”

Section: Methodsmentioning

confidence: 99%

A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis

et al. 2023

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Among drug-induced adverse events, pancreatitis is life-threatening and results in substantial morbidity. A prototype example is the pancreatitis caused by asparaginase, a crucial drug used to treat acute lymphoblastic leukemia (ALL). Here, we used a systems approach to identify the factors affecting asparaginase-associated pancreatitis (AAP). Connectivity Map analysis of the transcriptomic data showed that asparaginase-induced gene signatures were potentially reversed by retinoids (vitamin A and its analogs). Analysis of a large electronic health record database (TriNetX) and the U.S. Federal Drug Administration Adverse Events Reporting System demonstrated a reduction in AAP risk with concomitant exposure to vitamin A. Furthermore, we performed a global metabolomic screening of plasma samples from 24 individuals with ALL who developed pancreatitis (cases) and 26 individuals with ALL who did not develop pancreatitis (controls), before and after a single exposure to asparaginase. Screening from this discovery cohort revealed that plasma carotenoids were lower in the cases than in controls. This finding was validated in a larger external cohort. A 30-day dietary recall showed that the cases received less dietary vitamin A than the controls did. In mice, asparaginase administration alone was sufficient to reduce circulating and hepatic retinol. Based on these data, we propose that circulating retinoids protect against pancreatic inflammation and that asparaginase reduces circulating retinoids. Moreover, we show that AAP is more likely to develop with reduced dietary vitamin A intake. The systems approach taken for AAP provides an impetus to examine the role of dietary vitamin A supplementation in preventing or treating AAP.

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“…RNA extraction from heart, liver and muscle tissues, cDNA synthesis, and real-time RT-PCR were performed as previously described. 40 Briefly, for heart extraction, total RNA was isolated using RNAB according to the manufacturer's instructions (NC9270490, ThermoFisher, Rockford, IL, USA). RNA purity was determined by Nanodrop 2000 Spectrophotometer (ThermoFisher, Rockford, IL, USA).…”

Section: Rt-pcr Analysismentioning

confidence: 99%

“…After reverse transcription to complementary DNA (cDNA), target gene mRNA expression was quantified by real-time RT-PCR using the Applied Biosystems QuantStudio 3 instrument (Applied Biosystem, US). Sequences for primers used in this study have been previously published 22,36,40,41 or are listed in Table S1. Samples were run in duplicate; data were quantified using the 2 (−∆∆Ct) method and results were expressed as a fold change from the control wild-type or vehicle groups of the same genotype.…”

Section: Rt-pcr Analysismentioning

confidence: 99%

Retinoic acid regulates pyruvate dehydrogenase kinase 4 (Pdk4) to modulate fuel utilization in the adult heart: Insights from wild‐type and β‐carotene 9′,10′ oxygenase knockout mice

et al. 2022

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Regulation of the pyruvate dehydrogenase (PDH) complex by the pyruvate dehydrogenase kinase PDK4 enables the heart to respond to fluctuations in energy demands and substrate availability. Retinoic acid, the transcriptionally active form of vitamin A, is known to be involved in the regulation of cardiac function and growth during embryogenesis as well as under pathological conditions. Whether retinoic

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Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions

Cited by 16 publications

References 81 publications

Assessment of <i>Balanites aegyptiaca</i> and <i>Sesamum indicum</i> Artisanal Oils Quality and Vitamin Contents

Assessment of <i>Balanites aegyptiaca</i> and <i>Sesamum indicum</i> Artisanal Oils Quality and Vitamin Contents

A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis

Retinoic acid regulates pyruvate dehydrogenase kinase 4 (Pdk4) to modulate fuel utilization in the adult heart: Insights from wild‐type and β‐carotene 9′,10′ oxygenase knockout mice

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Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions

Cited by 16 publications

References 81 publications

Assessment of &lt;i&gt;Balanites aegyptiaca&lt;/i&gt; and &lt;i&gt;Sesamum indicum&lt;/i&gt; Artisanal Oils Quality and Vitamin Contents

Assessment of &lt;i&gt;Balanites aegyptiaca&lt;/i&gt; and &lt;i&gt;Sesamum indicum&lt;/i&gt; Artisanal Oils Quality and Vitamin Contents

A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis

Retinoic acid regulates pyruvate dehydrogenase kinase 4 (Pdk4) to modulate fuel utilization in the adult heart: Insights from wild‐type and β‐carotene 9′,10′ oxygenase knockout mice

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Assessment of <i>Balanites aegyptiaca</i> and <i>Sesamum indicum</i> Artisanal Oils Quality and Vitamin Contents

Assessment of <i>Balanites aegyptiaca</i> and <i>Sesamum indicum</i> Artisanal Oils Quality and Vitamin Contents