Impact of various wound dressings on wound bed neoangiogenesis in patients with different forms of diabetic foot syndrome

Zaitseva, Ekaterina L.; Tokmakova, Alla Y.; Токмакова, А. Ю.; Доронина, Л. П.; Voronkova, I A; Galstyan, Gagik Radikovich; Галстян, Г. Р.; Shestakova, Marina Vladimirovna; Shestakova, Marina V.

doi:10.17116/terarkh2017891012-16

Cited by 2 publications

(2 citation statements)

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“…2 Diabetes resulting in peripheral neuropathy and vasculopathy, which causes dry and irritated toes and eventually results in sores that will not heal in time. 3 Sadly, there has been little effect on the number of amputations related to diabetes in the last few decades. 4 On the other hand, a few countries, including Belgium, have successfully achieved a reduction in the incidence of diabetes-related adverse events following systematic organizational reforms.…”

Section: Introductionmentioning

confidence: 99%

The effect of negative pressure wound therapy on the outcome of diabetic foot ulcers: A meta‐analysis

Zhang,

Liu,

Yan

et al. 2024

International Wound Journal

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Negative pressure injury is one of the auxiliary methods of treating diabetes foot ulcers. It has been shown to be superior to conventional techniques in randomized controlled trials (RCTs). Nevertheless, the results of observational research are still scarce. A systematic review of RCTs and observations was carried out to evaluate the effectiveness and security of negative pressure wound therapy (NPWT) treatment for diabetes foot ulcers. Three English e‐databases have been found for NPWT research. The meta‐analyses of the comparative studies provided point estimates of results. Intermediate results were given as median and binary values were given in the form of odds ratios (OR). Seventeen trials, 13 RCTs and four randomized, controlled trials were found in the survey. Of these, 831 were treated with NPWT, 834 were treated with standard therapy. A total of 14 studies have been conducted to investigate the influence of NPWT on the healing of diabetic foot ulcers(DFU). In the study, NPWT was shown to speed up the healing of the wound in DFU patients(OR, 2.57; 95% CI, 1.72, 3.85 p < 0.0001). A subgroup analysis showed that NPWT was associated with an acceleration of the wound healing rate in 10 RCT trials (OR, 2.48; 95% CI, 1.58, 3.89 p < 0.001). In the four nRCT trials, NPWT was also shown to speed up the healing of the wound(OR, 2.95; 95% CI, 1.03, 8.42 p = 0.04). In 11 studies, the influence of NPWT on amputations of diabetes mellitus (DM) foot ulcers was investigated. The results showed that NPWT was associated with a reduction in amputations (OR, 0.53; 95% CI, 0.37, 0.74 p = 0.0002).In a subgroup of RCT trials, nine RCT trials showed a reduction in amputations(OR, 0.61; 95% CI, 0.43, 0.87 p = 0.007). In both nRCT trials, NPWT also showed a reduction in amputations (OR, 0.03; 95% CI, 0.00, 0.24 p = 0.001). Generally speaking, NPWT can help to heal the wound and lower the risk of amputations in people with diabetes. The subgroup analysis showed similar results for the RCT and non‐RCT trials. NPWT can be used to treat diabetes foot ulcers caused by diabetes.

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Section: Introductionmentioning

confidence: 99%

The effect of negative pressure wound therapy on the outcome of diabetic foot ulcers: A meta‐analysis

Zhang,

Liu,

Yan

et al. 2024

International Wound Journal

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“…Debridement is one of the gold standards in wound healing management, significantly contributing to the healing process of the wound, including the diabetic ulcer 5. Available data on the use of dressings in diabetic wounds is limited still there is evidence of their role in prevention of infection and enhancement of wound healing 6,7…”

Section: Introductionmentioning

confidence: 99%

Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers

et al. 2019

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Objective: To compare the effects of simple saline dressings versus topical vancomycin dressings on Methicillin-resistant Staphylococcus Aureus positive chronic diabetic foot ulcers. Methods: It was quasi experimental study conducted in Combined Military Hospital Kohat and PNS-Shifa Hospital Karachi from 01 January 2017 to 31 December 2017. A total of 23 patients were included based on non-probability convenient sampling who had diabetes and presented with foot ulcers for more than two weeks showing positive growth of Methicillin-Resistant Staphylococcus Aureus. The patients were treated with simple saline soaked dressings and debridement at first for three weeks followed by three weeks of topical vancomycin dressings with debridement. Thus patients served as their own controls Results: The average change in surface area with saline dressing was +1.73 ±1.53cm2 per week whereas with vancomycin soaked dressing it was --0.06±1.60 cm2 per week (p <0.05). The average exudate also decreased from 1.78±1.23 to 0.99±0.72 (p<0.05) and same trend was observed in percentage of slough covering the ulcer from 45% ± 22.3% to 24.3% ±12.90% (p<0.05) with vancomycin dressing. Moreover, fifteen patients had negative culture for MRSA within 2 weeks. Conclusion: Vancomycin impregnated dressing in MRSA positive Diabetic foot may help achieve early healing as compared to simple conventional dressings with no systemic toxicity. doi: https://doi.org/10.12669/pjms.35.4.368 How to cite this:Saif AB, Jabbar S, Akhtar MS, Mushtaq A, Tariq M. Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.368 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Impact of various wound dressings on wound bed neoangiogenesis in patients with different forms of diabetic foot syndrome

Abstract: Vacuum (NP) therapy versus standard therapy most effectively affects wound bed neoangiogenesis. This is reflected in the increased local tissue microhemodynamics, as confirmed by immunohistochemical examination.

Cited by 2 publications

References 9 publications

The effect of negative pressure wound therapy on the outcome of diabetic foot ulcers: A meta‐analysis

The effect of negative pressure wound therapy on the outcome of diabetic foot ulcers: A meta‐analysis

Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers

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