Impact of use of frozen section assessment of operative margins on survival in oral cancer

Pathak, Kumar Alok; Nason, Richard W.; Penner, Carla; Viallet, Norbert R.; Sutherland, Donna; Kerr, Paul

doi:10.1016/j.tripleo.2008.09.028

Cited by 54 publications

(56 citation statements)

References 30 publications

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“…The use of frozen sections is in dispute because of discrepancies between the frozen section report and the final margin status and the difficulty of establishing a mutual understanding between surgeons and pathologists of the various pieces of information in a small segment of tissue 3,20 . Some reports have shown that adding intraoperative imprint cytology can be more useful than frozen sections alone for diagnostic accuracy 2,6 .…”

Section: Discussionmentioning

confidence: 99%

Colorimetric analysis of unstained lesions surrounding oral squamous cell carcinomas and oral potentially malignant disorders using iodine

Maeda¹,

Suzuki²,

Ooyama³

et al. 2010

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Colorimetric analysis of unstained lesions surrounding oral squamous cell carcinomas and oral potentially malignant disorders using iodine

Maeda¹,

Suzuki²,

Ooyama³

et al. 2010

International Journal of Oral and Maxillofacial Surgery

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“…DiNardo et al (12) found this rate as 98.3% for 420 FSE from 80 patients having squamous cell carcinoma in the head and neck region, but the reliability rate of 71.3% reported for near or positive surgical margin is a more remarkable finding of this study. Pathak et al (13) investigated oral cavity carcinomas in 416 patients in their series and they stated that FSE did not affect local recurrence and survival. In our literature review, only one study investigating the reliability of FSE in TOLL was found.…”

Section: Discussionmentioning

confidence: 99%

Reliability of Frozen Section Pathology in Transoral Laser Laryngectomy

Ocak

Beton

Аббасова

et al. 2015

Turk Arch Otorhinolaryngol

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Objective: To evaluate the reliability of frozen section analysis in transoral laser laryngectomy (TOLL).Methods: A retrospective analysis was conducted for patients who underwent TOLL in a university hospital between January 2012 and February 2014. The grade of the tumor and the histopathological diagnosis were noted. The results of frozen section pathologies and routine histological examinations were compared.Results: A total number of 84 sections from 21 patients with a mean age of 57.3 years were included in the study. All the patients were operated with superpulse continuous mode carbon dioxide laser with a power of 5-8 watts. Squamous cell carcinoma was histologically diagnosed in all patients. The tumor was grade 1 in 80.95% of the patients, grade 2 in 9.52%, and grade 3 in 9.52%. A routine histopathological examination confirmed the frozen section in 94.04% of the patients. Conclusion:Laser surgery is a commonly preferred treatment modality in early-stage laryngeal carcinomas, in particular. However, a safe surgical margin is a debate in transoral laser surgery. In light of our results, we can conclude that frozen section pathology is a reliable method to achieve safe surgical margins in TOLL. Keywords

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“…Byers et al [11] found that the surgeon was able to obtain clear margins in 67 % cases only. Pathak et al [12] found that the accuracy rate of frozen in predicting clear margin status was 70.4 %, while the rate of clinical judgment was 67.4 % in achieving clear margins. Kerawala et al [13] reported an error of more than a centimeter in relocating possible site for revision of margin in 32 % of cases.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Frozen Section in T1, T2 Carcinoma of Oral Cavity

Gokavarapu

Rao

Patnaik

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Complex anatomy of oral cavity makes it difficult for a surgeon to assess margins of oral cancer accurately and positive margins compromise loco regional disease control, thus surgeon may rely on frozen section assessment for marginal status. We discussed the prognostic value of frozen section in early carcinoma of oral cavity. 90 patients with pT1 and pT2 oral cavity cancer operated from January 2010 to December 2011 under single consultant surgeon were retrospectively evaluated. Log rank test and multivariate cox regression model was used for testing frozen section against the survival and recurrence free status. Survival of patients with positive or negative frozen section was significant (p = 0.037), Survival of patients with positive or negative histology report was significant (p = 0.004), however; prognosis of patients with positive margins despite revision under frozen control was poorer to the patients with negative margin. Frozen section assessment is accurate but their use in the surgery of oral cavity cancer might not improve loco regional disease control or survival when used routinely.

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Impact of use of frozen section assessment of operative margins on survival in oral cancer

Cited by 54 publications

References 30 publications

Colorimetric analysis of unstained lesions surrounding oral squamous cell carcinomas and oral potentially malignant disorders using iodine

Colorimetric analysis of unstained lesions surrounding oral squamous cell carcinomas and oral potentially malignant disorders using iodine

Reliability of Frozen Section Pathology in Transoral Laser Laryngectomy

Prognostic Value of Frozen Section in T1, T2 Carcinoma of Oral Cavity

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