Impact of UDST: A step forward to end TB

Sharma, Amit; Vijay, Sunil; Mathur, Rishab; Meena, H.S.

doi:10.1016/j.ijtb.2020.02.009

Cited by 2 publications

(1 citation statement)

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“…Divergence from the UDST algorithm has been found in other studies also 15 . However, at a sufficient scale, UDST can control MDR-TB transmission by detecting a more significant number of DR-TB cases 16 . Weekly monitoring of NIKSHAY ID of patient referrals between DMC and laboratories and developing a feedback mechanism to the DMC might improve testing coverage.…”

Section: Resultsmentioning

confidence: 99%

Status of universal drug-susceptibility testing among sputum smear-positive tuberculosis patients diagnosed at a tertiary care centre

Debolina,

Palanivel,

Manju

et al. 2023

Indian Journal of Medical Research

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Background & objectives: This study was aimed at estimating the proportion among sputum smear-positive tuberculosis (TB) patients diagnosed at a tertiary care centre in India, who did not undergo universal drug-susceptibility testing (UDST), assessing the sociodemographic and morbidity-related factors associated with it, ascertaining the reasons for not getting tested and estimating the proportion with any drug resistance (DR). Methods: TB Notification Register and TB Laboratory Register, maintained in Designated Microscopy Centre and Intermediate Research Laboratory, respectively were used to obtain the patient details and information regarding UDST and DR-TB status. Under UDST, the TB patients had undergone rapid molecular tests to check for any DR. TB patients who dropped out of this strategy (those who did not submit a sputum sample for DR testing even after being instructed) were telephonically contacted and asked regarding reasons for not getting themselves tested. Results: Of the 215 patients, 74 [34.4%, 95% confidence interval (CI): 28.1-41.2] did not undergo UDST. Of these 74 participants, 60 per cent reported the reason that they were not informed regarding the drug-susceptibility test. Among the 141 patients who underwent UDST, six (4.3%, 95%. CI: 1.58-9.03) had DR. Non-UDST patients were significantly more in percentage among TB patients who were aged <30 years (adjusted prevalence ratio 2.36; 95% CI: 1.19-4.68) compared to >60 years. Interpretation & conclusions: The present findings point towards a need to sensitize healthcare workers and TB patients to improve UDST.

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Section: Resultsmentioning

confidence: 99%