Impact of treatment satisfaction on quality of life of patients with acromegaly

Kepicoglu, Hasan; Hatipoğlu, Esra; Bulut, İrem; Darıcı, Ezgi; Hizli, Naz; Kadıoğlu, Pınar

doi:10.1007/s11102-013-0544-7

Cited by 43 publications

(34 citation statements)

References 22 publications

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“…According to published studies men had better quality of life in some studies [4,16,19], whereas others show opposite results [5,20,21]. In our study younger patients had slightly higher quality of life scores, but again, these failed to reach statistical significance.…”

Section: Resultscontrasting

confidence: 69%

“…In our study younger patients had slightly higher quality of life scores, but again, these failed to reach statistical significance. Previous studies showed that younger age was associated with better quality of life [14] and negative influence of age has been reported [5], whereas other studies have found no relationship [4,16,21,22]. In a recent Japanese study young age and previous radiotherapy were found to be associated with lower quality of life [23].…”

Section: Resultsmentioning

confidence: 94%

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Quality of Life in Acromegaly and the Association with the Clinical Parameters of the Disease

Papadakis¹

2017

EMIJ

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Background: Quality of life is currently considered a major factor in the assessment of disease outcome. Most patients with acromegaly present with skin, bone and soft tissue alterations, as well as hypertension, diabetes mellitus and other cardiovascular symptoms and all these affect patient's mood, personality, interpersonal relationships and social behavior. The aim of this study was to assess quality of life in acromegaly and the association with the clinical characteristics of the disease. Methods:This cross-sectional study included a total of 101 (45 male, 56 female) patients with acromegaly, mean age 59.51 ± 1.35 years (mean ± SEM), with a disease duration of 12.88 ± 0.96 years. All subjects completed the Acromegaly Quality of Life Questionnaire (AcroQoL). Results:Total (mean ± SEM) score was 86.15±1.37 (min22-max110), psychological parameters score was 54.98±0,95 (min 14-max 70), appearance score was 25.95±0.54 (min 7-max 35), personal relationship score was 29.37±0.52 (min7-max 35) and finally physical parameters score was 30.93±0.58 (min8-max 40). Women and older patients showed slightly worse scores. Patients with macroadenomas, those who received radiotherapy, and those with comorbidities appeared with less mean total QoL scores. Conclusion:The assessment of quality of life is a critical end point in the management of acromegaly and improvement of quality of life is a major aim in the therapeutic management of acromegaly.

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Section: Resultscontrasting

confidence: 69%

Section: Resultsmentioning

confidence: 94%

Quality of Life in Acromegaly and the Association with the Clinical Parameters of the Disease

Papadakis¹

2017

EMIJ

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“…Generally, achieving a biochemically-controlled status only by surgery is superior to the continuous pharmaceutical therapy required for this status. Furthermore, the economic burden and inconvenience of pharmaceutical therapy could be of concern to patients with acromegaly [28]. We speculate that these disadvantages could deteriorate the comprehensive QoL in patients receiving pharmaceutical therapy, even if their physical condition is not impaired in a biochemically-controlled status.…”

Section: Discussionmentioning

confidence: 98%

“…One possibility to explain these results is that the burden of disease could indirectly impair QoL. Indeed, illness perception and treatment satisfaction are associated with QoL in patients with acromegaly [28,29]. Such factors could affect the psychological condition indirectly but perhaps affect not only the appearance score.…”

Section: Discussionmentioning

confidence: 99%

The quality of life in acromegalic patients with biochemical remission by surgery alone is superior to that in those with pharmaceutical therapy without radiotherapy, using the newly developed Japanese version of the AcroQoL

et al. 2015

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“…Webb et al (8) developed the AcroQoL using literature searches, interviews with expert endocrinologists and patients, and exploratory statistical methods, and they found the measure to contain a threesubscale, a two-subscale, and a single total score scoring method. At present, many studies have measured QoL and changes in QoL predominantly using the single total score of the AcroQoL (9,10,11). However, the World Health Organization (WHO) has recommended that QoL be treated as a multidimensional construct that, at a minimum, contains physical, psychological, and social aspects of QoL (12).…”

Section: Introductionmentioning

confidence: 99%

Total score or subscales in scoring the acromegaly quality of life questionnaire: using novel confirmatory methods to compare scoring options

Felt

Depaoli

Pereira

et al. 2015

European Journal of Endocrinology

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Context: Impaired quality of life (QoL) is common in patients after long-term remission of acromegaly. The acromegaly QoL (AcroQoL) is a disease-specific QoL questionnaire for patients diagnosed with acromegaly. The summed total score is the most frequently used scoring method of the AcroQoL. However, the total score does not capture all of the aspects of QoL that are outlined by the World Health Organization (WHO). Objective: The aim of the present study was to use novel and sophisticated confirmatory methods to identify the optimal number of subscales for the AcroQoL. Design and patients: Patients in remission from acromegaly were recruited from the Leiden University Medical Center and were asked to complete the AcroQoL (Dutch version) questionnaire (nZ72). Results: The three-subscale version of the AcroQoL consisted of subscales reflecting Physical Complaints, Appearance Issues, and Personal Relations Issues related to QoL. Model fit indices (i.e., comparative fit index and root mean square error of approximation) indicated that the three-subscale version represented the data better than the total score and two-subscale models did. A c 2 difference test indicated that the three-subscale model was a significantly better fit than the total score and two-subscale models were (P!0.05). Conclusion: Model fit and comparison statistics indicate that the three-subscale model is a better scoring method than the total score and two-subscale versions of the AcroQoL are. The three-subscale version also better reflected the WHO's recommendation of using a multidimensional measure of QoL than the total score and two-subscale methods did. Therefore, it is recommended that values from the three-subscales of the AcroQoL be reported in future research.

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Impact of treatment satisfaction on quality of life of patients with acromegaly

Abstract: In acromegaly, quality of life, status of depression and satisfaction of the subjects with their treatment are intercorrelated.

Cited by 43 publications

References 22 publications

Quality of Life in Acromegaly and the Association with the Clinical Parameters of the Disease

Quality of Life in Acromegaly and the Association with the Clinical Parameters of the Disease

The quality of life in acromegalic patients with biochemical remission by surgery alone is superior to that in those with pharmaceutical therapy without radiotherapy, using the newly developed Japanese version of the AcroQoL

Total score or subscales in scoring the acromegaly quality of life questionnaire: using novel confirmatory methods to compare scoring options

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