Impact of Transmission Control Measures on the Epidemiology of Maxillofacial Injuries in Wuhan City During the COVID-19 Epidemic

Yang, Yuting; Xing, Xin; Sreekissoon, Senjeet; Li, Zhi

doi:10.1097/scs.0000000000007427

Cited by 4 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common cause of fractures in both groups was falls, as previously reported in other studies ( 11 , 17 ). Interestingly, in the pandemic year, road traffic accidents increased while interpersonal assaults decreased.…”

Section: Discussionsupporting

confidence: 84%

Impact of the coronavirus pandemic on maxillofacial trauma: A retrospective study in southern Spain

Infante-Cossio¹,

Fernandez-Mayoralas-Gomez²,

Gonzalez-Perez³

et al. 2022

Med Oral

View full text Add to dashboard Cite

Background The coronavirus pandemic has impacted health systems worldwide, with Spain being one of the most affected countries. However, little is known about the extent to which the effects of staying home, social distancing, and quarantine measures have influenced the epidemiology of patients with maxillofacial trauma. The aim of this study was to analyze the impact of the coronavirus pandemic on the incidence, demographic patterns, and characteristics of maxillofacial fractures in the largest hospital in southern Spain. Material and Methods Data from patients who underwent surgery for maxillofacial fractures during the first year of the pandemic between 16 March 2020 and 14 March 2021 (pandemic group) were retrospectively compared with a control group during the equivalent period of the previous year (pre-pandemic group). The incidence was compared by weeks and by lockdown periods of the population. Demographic information, aetioloy, fracture characteristics, treatment performed, and days of preoperative stay were evaluated. Descriptive and bivariate statistics were calculated ( p <0.05). Results During the first year of the pandemic, there was a 35.2% reduction in maxillofacial fractures (n=59) compared to the pre-pandemic year (n=91, p =0.040). A significant drop was detected during the total home lockdown period of the population ( p =0.028). In the pandemic group, there was a reduction in fractures due to interpersonal aggressions, an increase in panfacial fractures, a significant increase in other non-facial injuries associated with polytrauma ( p =0.037), a higher number of open reduction procedures with internal fixation, and a significantly longer mean preoperative stay ( p =0.016). Conclusions The first pandemic year was associated with a decline in the frequency of maxillofacial trauma and a change in the pattern and characteristics of fractures. Inter-annual epidemiological knowledge of maxillofacial fractures may be useful for more efficient planning of resource allocation and surgical practice strategy during future coronavirus outbreaks and population lockdowns. Key words: SARS-CoV-2, coronavirus infection, pandemic, maxillofacial trauma, Spain.

show abstract

Section: Discussionsupporting

confidence: 84%

Impact of the coronavirus pandemic on maxillofacial trauma: A retrospective study in southern Spain

Infante-Cossio¹,

Fernandez-Mayoralas-Gomez²,

Gonzalez-Perez³

et al. 2022

Med Oral

View full text Add to dashboard Cite

show abstract

“…Unlike our study, previous studies showed that the main causes of MFTs were motor vehicle crashes [29] and assault [30]. Some of the studies, however, found falls to be the main cause of MFTs, similar to our study [16,17,19]. Both during the pandemic and the previous year of pandemic, the only cause of MFTs was fall in patients aged ≥65 years; however, one patient had assault-induced MFT in the COVID-19 pandemic.…”

Section: Original Articlesupporting

confidence: 79%

“…Our study results showed that the number of patients admitted to ED with MFTs decreased by 43.2% during the pandemic compared to the previous year. In the literature, the rate of MFTs decreased by 80% [13][14][15][16][17][18][19]. This can be attributed to the higher time spent at home due to restrictions worldwide.…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 pandemic on maxillofacial trauma etiology

Özkan

Saraç

2021

Marmara Medical Journal

View full text Add to dashboard Cite

Objective: Maxillofacial trauma (MFT) is a frequent presentation in the emergency department (ED) which requires a multidisciplinary approach. Although, its etiology and diversity of injuries are almost similar worldwide, the causes may differ among the countries depending on the sociocultural and environmental factors and local traffic regulations. This study aims to evaluate etiologies of maxillofacial traumas (MFTs) in ED and to compare etiologies of MFTs during COVID-19 pandemic with the previous year. Patients and Methods: Totally 84 (61 males, 23 females) patients admitted to ED of our center with MFT between March 15 th -April 30 th , 2020 were included. The control group consisted of 148 (112 males, 36 females) MFT patients admitted to ED in the previous year (March 15 th -April 30 th , 2019). Data including age, sex, cause of trauma, treatment, and COVID-19 infection status within 14 days after ED admission were compared between groups. Results: Mean age was 31.88±2.53 years in the patient group and 31.40±1.74 years in the control group. Number of patients admitted to ED with MFTs decreased by 43.3% during pandemic compared to the previous year. Majority of MFTs occurred at home, followed by public places, traffic, and workplaces in both time periods. During pandemic, the rate of home accidents increased and MFTs occurred in the public places decreased. Conclusion: COVID-19 pandemic-mandated social restrictions lead to a decrease in the number of MFTs. However, home accidents are the main cause of MFTs. Spread of COVID-19 infection in the hospital setting can be minimized with necessary precautions.

show abstract

“…COVID-19 has affected ~199 M individuals, resulting in ~4.24 M deaths worldwide as of August 3, 2021. The scientific community has made tireless efforts to find a suitable remedy for COVID-19 since it was first reported in China's Wuhan Province (Yamamoto et al, 2020;Li et al, 2021;Mei et al, 2021;Yang et al, 2021;Zhu et al, 2021). Of most concern at present is the arrival of new, mutated, genetic variants (e.g.…”

Section: Introductionmentioning

confidence: 99%

Niclosamide-Exfoliated Anionic Clay Nanohybrid Repurposed as an Antiviral Drug for Tackling Covid-19; Oral Formulation with Tween 60/Eudragit S100

Rejinold

Piao

Choi

et al. 2021

Clays and clay miner.

View full text Add to dashboard Cite

The ongoing pandemic, COVID-19 (SARS-CoV-2), has afflicted millions of people around the world, necessitating that the scientific community work, diligently and promptly, on suitable medicaments. Although vaccination programs have been run globally, the new variants of COVID-19 make it difficult to restrict the spread of the virus by vaccination alone. The combination of vaccination with anti-viral drug formulation is an ideal strategy for tackling the current pandemic situation. Drugs approved by the United States Food and Drug Administration (FDA), such as Remdesivir, have been found to be of little or no benefit. On the other hand, re-purposing of FDA-approved drugs, such as niclosamide (NIC), has offered promise but its applicability is limited due to its poor aqueous solubility and, therefore, low bioavailability. With advanced nano-pharmaceutical approaches, re-purposing this drug in a suitable drug-carrier for a better outcome may be possible. In the current study, an attempt was made to explore the loading of NIC into exfoliated layered double hydroxide nanoparticles (X-LDH NPs); prepared NIC-X-LDH NPs were further modified with eudragit S100 (ES100), an enteric coating polymer, to make the final product, ES100-NIC-X-LDH NPs, to improve absorption by the gastro/intestinal tract (GIT). Furthermore, Tween 60 was added as a coating on ES100-NIC-X-LDH NPs, not just to enhance its in vitro and in vivo stability, but also to enhance its mucoadhesive property, and to obtain, ultimately, better in vivo pharmacokinetic (PK) parameters upon oral administration. Release of NIC from Tween 60-ES100-NIC-X-LDH NPs was found to be greater under gastro/intestinal solution within a shorter period of time than the uncoated samples. The in vivo analysis revealed that Tween 60-ES100-NIC-X-LDH NPs were able to maintain a therapeutically relevant NIC plasma concentration in terms of PK parameters compared to the commercially available Yomesan®, proving that the new formulation might prove to be an effective oral drug-delivery system to deal with the SARS-CoV-2 viral infections. Further studies are required to ensure their safety and anti-viral efficacy.

show abstract

Impact of Transmission Control Measures on the Epidemiology of Maxillofacial Injuries in Wuhan City During the COVID-19 Epidemic

Abstract: Supplemental Digital Content is available in the text

Cited by 4 publications

References 34 publications

Impact of the coronavirus pandemic on maxillofacial trauma: A retrospective study in southern Spain

Impact of the coronavirus pandemic on maxillofacial trauma: A retrospective study in southern Spain

Impact of COVID-19 pandemic on maxillofacial trauma etiology

Niclosamide-Exfoliated Anionic Clay Nanohybrid Repurposed as an Antiviral Drug for Tackling Covid-19; Oral Formulation with Tween 60/Eudragit S100

Contact Info

Product

Resources

About