Impact of trandolapril therapy and its combination with a calcium channel blocker on plasma adiponectin levels in patients with type 2 diabetes and hypertension

Rubio-Guerra, Alberto Francisco; Vargas‐Robles, Hilda; Vargas-Ayala, Germán; Rodríguez-López, Leticia; Castro-Serna, David; Escalante-Acosta, Bruno Alfonso

doi:10.1177/1753944711415307

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…Type 2 diabetic and hypertensive subjects are known to have higher plasma resistin levels. Trandolapril was found to be decreasing resistin levels alone or in combination with verapamil [23]. TNF-alpha levels were reported to be higher in obese type 2 diabetic patients with IR compared to ones without IR and controls [25].…”

Section: Discussionmentioning

confidence: 92%

“…TNF-alpha levels were reported to be higher in obese type 2 diabetic patients with IR compared to ones without IR and controls [25]. It's known that TNF-alpha increases resistin production and has inverse relation with adiponectin [23]. Lipophylicity of trandolapril could improve insulin mediated glucose utilization in adipose tissue via changes in adiponectin, resistin and/ or TNF-alpha, which are known to be a involved in obesity related IR.…”

Section: Discussionmentioning

confidence: 99%

“…Multivariate model showed that changes in BP and BMI did not affect the decrease in HOMA-IR in all patients. ACEIs may affect insulin sensitivity, in part, by modulating some cytokines and inflammatory markers [22][23][24]. Adiponectin is a cytokine that has protective effect against cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level

Ersoy¹,

Elbüken²,

Tuncel

2014

Med-Science

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level

Ersoy¹,

Elbüken²,

Tuncel

2014

Med-Science

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“…A total of 30 hypertensive patients with type 2 diabetes mellitus (>12 months) were included in this study, all of them were thiazolidinedione-naïve, GLP-1 analogues-naïve, statin-naïve and ACE/ARB-naïve, because those drugs have been shown to raise circulating levels of adiponectin [1,7] and to decrease those of resistin [4,8]. A control group of 30 normotensive nondiabetic age-matched subjects was also included.…”

Section: Methodsmentioning

confidence: 99%

“…Endothelial dysfunction is a common feature in both hypertension and diabetes mellitus and leads to atherosclerosis, the major cause of death in subjects with diabetes [1]. …”

mentioning

confidence: 99%

Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

Rubio-Guerra¹,

Cabrera-Miranda²,

Vargas‐Robles

et al. 2013

Cardiology

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Background: Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial infarction and stroke. Objective: To evaluate the correlation between adipokine levels with CIMT in hypertensive type 2 diabetic patients. Methods: Serum levels of adiponectin and resistin levels were measured by ELISA in 30 type 2 diabetic patients with never-treated hypertension and in age-matched healthy controls. The CIMT (B-mode color imaging of extracranial carotid arteries using high-resolution ultrasound) was also obtained. The relationship between adipokine levels and the adiponectin/resistin index with the CIMT was assessed by the Pearson correlation coefficient test. Results: Adiponectin was lower (p < 0.05), and resistin higher (p < 0.01)in patients than in controls, CIMT correlated positively with resistin (R = 0.45, p < 0.02) and the adiponectin/resistin index (R = 0.58, p < 0.001), but not with adiponectin levels (r = -0.11, p > 0.1) in patients. Whereas only adiponectin levels correlated - negatively - with CIMT (r = -0.39, p < 0.02) in controls. Conclusion: Our results shown that the adiponectin/resistin index seems to be more strongly associated with atherosclerosis than adipokine levels, and may be used as a reliable marker of cardiovascular risk in type 2 diabetic hypertensive patients.

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Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease

et al. 2013

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Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. In the last two decades, the prevalence of NAFLD has been growing in most developed countries, mainly as a consequence of its close association with obesity and diabetes mellitus. The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression have not been completely understood. Adipocytes produce and secrete several bioactive substances known as adipocytokines which are implicated in the pathogenesis of the disease. Among them, adiponectin is an insulin-sensitizing adipocytokine possessing multiple beneficial effects on obesity-related medical complication. This review focuses on the role of adiponectin in NAFLD pathogenesis and its potential use as a diagnostic tool but also as therapeutic target for NAFLD management.

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Impact of trandolapril therapy and its combination with a calcium channel blocker on plasma adiponectin levels in patients with type 2 diabetes and hypertension

Abstract: Our results show that the addition of FDTV to T produced a greater increase on adiponectin levels than trandolapril alone.

Cited by 5 publications

References 18 publications

The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level

The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level

Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease

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